Gut-Bone Axis Meeting

21-23 JUNE 2021

This online meeting will be held over 3 consecutive days, 2 hours per day

This symposium brings together researchers and clinicians from the immunology, bone and gut fields with internationally renowned keynote speakers, orals selected from abstract submissions and poster presentations.

Traditionally, many would have thought that two physiological systems could hardly be more remote from one another than the skeleton and the GI tract. However, increasingly, key functional links between the two are being recognized. Given the central role of the gut in absorbing nutrients essential to bone development and homeostasis and given the well recognised links between GI pathology such as Coeliac disease and skeletal disease such as osteoporosis perhaps this is not so surprising.

Disorders of calcium and bone metabolism are common, affecting over 3 million people in the UK in the form of osteoporosis alone, and are linked to disturbances of gut function. Mechanisms including hormonal secretion, nutrient uptake, balance of gut microbiota, immune regulation and doubtless others yet to be described are all at play. Altered microbial composition is involved in a range of inflammatory conditions, both within and outside the gut, including rheumatoid arthritis, multiple sclerosis, inflammatory bowel diseases, diabetes, food allergies, eczema, and asthma as well as obesity and the metabolic syndrome. This themed scientific meeting aims to explore new and emerging areas that link gut and bone health.

Join us for world-class scientific and clinical presentations, discuss with the experts in the field and present your latest findings.

21 June: Day 1

Chaired by Nikki Horwood and Alastair Watson

3:00-4:00pm
Roberto Pacifici  (Emory, Atlanta)
'The gut microbiome mediates the activity of bone regulating hormones.'
4:00-4:30pm
Abstract talk 1 - G. Mabilleau
Abstract talk 2 - A. Wallimann
4:30-5:00pm
Frances Williams (KCL)
'Gut Microbiome and Rheumatoid Arthritis'
 

22 June: Day 2

Chaired by Jeremy Turner and Bill Fraser

3:00-3:30pm
Laura McCabe  (Michigan State University)
'Prevention of glucocorticoid induced osteoporosis and osteonecrosis by increasing gut health'
3:30-4:00pm
Abstract talk 3 - J. Halper
Abstract talk 4 - M. G. Hassan
4:00-4:30pm
Abstract talk 5 - M. Binata
Abstract talk 6 - L. Malaval
4:30-5:00pm
Duncan Bassett (Imperial College London)
'PYY a negative regulator of bone mass and strength'
 

23 June: Day 3

Chaired by Nikki Horwood and Carl Goodyear

3:00-3:30pm    
Claudine Blin-Wakkach (Université Côte d'Azur, Nice)
‘The reciprocal gut-bone dialogue in inflammatory osteoclastogenesis’
3:30-4:00pm
Mario Zaiss (University of Erlangen-Nuremberg)
'Pickin' up good 'fibrations' for bone'
4.00-4.30pm
Dirk Elewaut (University of Ghent)
'Mechanisms driving combined gut and joint inflammation in spondyloarthritis’
4.30-5.00pm
Christopher Hernandez (Cornell University)
'The Microbiome, Bone Strength and Orthopaedic Implants'

The abstract submission deadline is 28th May 2021

Scientific and Clinical abstracts will be marked by a panel of experts based on their originality, invention, scientific soundness and timeliness in the field.  Submitting authors will notified of the outcome of the selection committee by 1st June 2021.

Oral communications will be selected from the highest ranking abstracts submitted for the Gut-Bone Axis meeting. 

Posters will be available online throughout the meeting and Q&A forum will be hosted on the meeting website. Presenting authors should create a poster-style single Powerpoint file (.ppt or .pptx) and record a 2 minute summation of the main findings. 

Helpful guidelines for how to record your poster or presentation are available on howtogeek.com and the Microsoft Edu channel on YouTube.

Instructions on how to zoom in to a part of the poster for emphasis are available on the Microsoft support website.

When you are ready to submit your abstract, please use the pink button below to submit your details via Microsoft Forms.

Submit your abstract

Presentations will be judged throughout the meeting for the following awards;

Best oral presentation

• Young investigator (£150)
• Student (£150)

Poster prizes

• Best overall poster (£150)
• Best poster: scientific, clinical (2 x £75)

If embedded videos do not load correctly, they will fail to have a blue and white "play" symbol. To resolve this, please press F5 on your computer to refresh the page.
 

Roberto Pacifici (Emory University, Atlanta) - ‘The gut microbiome mediates the activity of bone regulating hormones’

Binata Marik Abstract Talk 'A study on the genetic basis of hypophosphatemic rickets' 

Alexandra Wallimann Abstract Talk 'Short-Chain Fatty Acids and Antibiotics Affect Local and Systemic Processes Relevant for Bone Healing'

Frances Williams (Kings College London) - ‘Gut Microbiome and Rheumatoid Arthritis’

If embedded videos do not load correctly, they will fail to have a blue and white "play" symbol. To resolve this, please press F5 on your computer to refresh the page.

Laura McCabe (Michigan State University) - ‘Prevention of glucocorticoid-induced osteoporosis and osteonecrosis by increasing gut health’

J. Halper - Single cell mapping of osteoclasts links inflammatory osteoclastogenesis to PRR activation

M. G. Hassan - Sex-specific differences in mouse offspring skulls due to altered maternal calcium and phosphorus exposure

G. Mabilleau - Development of dual GIP/GLP-2 analogues for the treatment of bone fragility

L. Malaval - Gene knockout of Bone Sialoprotein

Duncan Bassett (Imperial College London) - ‘PYY a negative regulator of bone mass and strength’

If embedded videos do not load correctly, they will fail to have a blue and white "play" symbol. To resolve this, please press F5 on your computer to refresh the page.

Claudine Blin-Wakkach (Université Côte d'Azur, Nice) - ‘The reciprocal gut-bone dialogue in inflammatory osteoclastogenesis’

Mario Zaiss (University of Erlangen-Nuremberg) - ‘Pickin’ up good 'fibrations' for bone’

Dirk Elewaut (University of Ghent) - ‘Mechanisms driving combined gut and joint inflammation in spondyloarthritis’

Christopher Hernandez (Cornell University) - ‘The Microbiome, Bone Strength and Orthopaedic Implants’