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Mistry Laboratory
Metabolic Regulation of Stem Cell Ageing and Leukaemia
The Mistry laboratory studies hematopoietic stem cells (HSCs) and how they change during normal aging and malignant transformation to leukaemia. We are particularly interested in the metabolic regulation of these processes. By defining these metabolic vulnerabilities, we aim to identify biomarkers of disease and uncover new therapeutic targets for leukemia.
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Group Leader: Dr Jayna Mistry
I am a scientific group leader in haematology at Norwich Medical School, University of East Anglia, UK. I completed my PhD at University of East Anglia and the Earlham Institute in the laboratory of Professor Stuart Rushworth studying the role of metabolism in stress haematopoiesis. I undertook post-doctoral training at The Jackson Laboratory, USA with Dr. Jennifer Trowbridge, understanding aging-associated mechanisms of Dnmt3a-mutant clonal haematopoiesis. I was a recipient of a JAX Scholar Award and a Leukemia & Lymphoma Society (LLS) Fellow Award, before setting up my own group at UEA in 2026.
Recent Lab Publications
Stromal Cell Senescence Augments Hematopoietic Cell Fitness in Clonal Hematopoiesis
Mistry J, Young K, Navarro Figueredo A, Edun G, Aguilar-Navarro A, Colom Diaz P, Telpoukhovskaia M, Fernandez Maestre I, Cai S, Götze K, Tikhonova, Levine R, Trowbridge J (2026) Nature Cell Biology, 28(8), pp. 1656–1670. doi:10.1038/s41556-026-02025-4Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis
Young K, Hosseini M, Mistry J, Morganti C, Mills T, Cai X, James B, Nye G, Fournier N, Voisin V, Chegini A, Schimmer A, Bader G, Egan G, Mansour M, Challen G, Pietras E, Fisher-Wellman K, Ito K, Chan S, Trowbridge J. (2025) Nature Communications, 16(1)Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness Versus Lineage Output in Dnmt3a-Mutant Clonal Hematopoiesis
SanMiguel J, Eudy E, Loberg M, Young K, Mistry J, Mujica K, Schwartz L, Stearns T, Challen G and Trowbridge J (2022). Cancer Discovery 2;12(12):2763-2773Free fatty-acid transport via CD36 drives β-oxidation-mediated hematopoietic stem cell response to infection. Nature Communications.
Mistry J, Hellmich C, Moore J, Jibril A, Macaulay I, Moreno-Gonzalez M, Di Palma F, Beraza N, Bowles K and Rushworth S, (2021). 8;12(1):7130.ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infection.
Mistry J, Marlein C, Moore J, Hellmich C, Wojtowicz E, Smith J, Macaulay I, Sun Y, Morfakis A, Patterson A, Horton R, Divekar D, Morris C, Haestier A, Di Palma F, Beraza N, Bowles K and Rushworth S (2019). Proceedings of the National Academy of Sciences, 3;116(49):24610-24619.