Our study teams are investigating the following projects surrounding medication use and dementia.
The ABCD (Anticholinergics, Benzodiazepines, Cognition and Dementia) study aims to understand the effect of anticholinergic medication, benzodiazepine and Z-drug use on cognitive decline and dementia incidence in older people.
This three-year study is advancing our knowledge of the effects of specific classes of commonly used medicines on cognitive decline and dementia incidence in the older population. We are using routine data collected through the Clinical Practice Research Datalink (CPRD) and data from two cohort studies, the MRC Cognitive Function and Ageing Study (MRC CFAS) and The Irish Longitudinal Study on Ageing (TILDA).
This study is funded by the Alzheimer's Society. Further details of the study design are described on the ABCD Research Plan page.
The ZED (Z drugs in Dementia) study aims to understand the benefits and harms of Z drug use for managing sleep disturbance in people with dementia.
Z drugs are commonly used to treat sleep disturbance however, there is evidence of adverse side effects including increased falls and reduced cognitive functioning. There has not been studies to test whether these drugs are safe or effective for people with dementia. We are using routine data collected through the CPRD and data from cohort and Randomised Controlled Trials (RCTs) to understand the benefits and harms of using these drugs.
The National Institute for Health Research (NIHR) Health Technology Assessment (HTA) programme has funded this two year study. Further details of the study design are described on the ZED Research Plan page.