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Norwich Skin Platform

The Norwich Skin Platform (NSP) aims to overcome limitations of human tissue supply to offer a bespoke treatment and analysis service allowing morphological, genetic, proteomic and immunological changes in primary human skin samples.

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Intraocular Lens Design

A novel process for intraocular lens (IOL) prototype development based on rapid computer-aided design, formulations for 3D printing, and post-printing finishing process.

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Multicomponent Nanoformulations

A complex targeted "nanoparticle within nanoparticle" system for multi-component drug delivery to provide a new chemotherapeutic modality for patients with locally advanced, metastatic or chemoresistant cancers.

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Epigenetic Fluorescent Probes

A novel method that allows the production of chemically labelled biological probes valuable for investigating and analysing epigenetic targets in disease.

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DynDom

DynDom is a fully automated program offering the determination of protein domains, hinge axes and amino acid residues that are involved in hinge bending.

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HaptiMOL

A haptic feedback tool that could help biologists and chemists understand the 3D conformations of proteins. This allows for a predicted protein structure to be explored by touch, giving much deeper insight into its conformation. 

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sRNA Sequencing

A novel, simple, yet robust solution to overcome cloning bias in sRNA libraries. The tools could be easily incorporated into existing sRNA cloning kits with minimum costs and readily available for use.

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Small RNA Workbench

A sRNA software package based on algorithms developed at UEA that performs a complete analysis of single or multiple-sample small RNA datasets from both plants and animals. The package can be used to identify interesting landmarks (e.g. novel micro RNA sequences) or perform other tasks such as profiling small RNA expression patterns in genetic data. 

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Antibody Drug Conjugates

A novel method to incorporate an ultra-potent natural drug – duocarmycin – into an antibody-drug conjugate using solid-phase synthetic methods. Incorporating this ultra-potent drug using simple synthetic methods offers new therapeutic pathways for cancer drug delivery.

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Topical Delivery

A novel approach for the delivery of bioactive ingredients to the skin with cosmetic and pharmaceutical application potential.

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DNA and RNA Ligase Plasmids

 Derivatives of the bacterial plasmid pET-16b containing genes from bacteriophage T4 that allow for the expression of one DNA (T4Dnl) and two RNA ligases (T4Rnl1A, and T4Rnl2) have been developed.

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Drug Coating Technology for Therapeutic Contact Lenses

Current treatment of ocular diseases such as glaucoma is predominantly managed using eye drops which have an extremely poor bioavailability (only 1-5% of the drug reaches its target) and are subject to poor patient adherence. With increased numbers of contact lenses users coming through into the population of newly diagnosed patients with chronic ocular conditions, using contact lenses as a means for delivery drug to the eye is an attractive approach to improve the drug absorption and therapeutic efficiency

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