Diabetes and Endocrinology Diabetes and Endocrinology

Centre Overview 

The Directorate is the largest Diabetes & Endocrine service in the East of England, and one of the largest in the UK, and information on the services and quality markers in this NHS University teaching hospital, the associated Norwich Medical School and Biomedical Research Centre at UEA, and a new functional and well-staffed Clinical Research and Trials Unit (CRTU) at these sites are available. The Directorate supports a full range of specialist and general clinical services, for a stable local population of 600,000, and a local diabetes population of 42,000 people with known and unknown diabetes (2011). There are active programmes for DAFNE, CSII, outreach services, primary care support, and mobile retinal screening, as well as among the largest and best described antenatal, paediatric and foot services in the UK. The Trust and UEA are part of the larger Norwich Research Park (NRP) which also includes the John Innes Centre, the Institute of Food Research, the Sainsbury Laboratory and The Earlham Institute and houses over 30 science and IT based companies and is one of Europe’s largest  concentrations of research in Health, Food and Environmental Sciences. An analysis of the most highly cited scientists in the UK over the past 20 years reveals that Norwich is ranked 4th in the UK after London, Cambridge and Oxford. The Acute Trust and Directorate staff have a long history of clinical – basic science collaboration with colleagues across the NRP, and research in this Directorate is integrated with and fully supported by the East of England DRN.    

Clinical Research Experience

The Consultant team in the Elsie Bertram Diabetes Centre are the most research active Directorate in this large University Teaching Hospital and offer a substantial range of expertise and in depth support for academic and industry associated studies. Since the original diabetes research unit (DRU) opened in 1995 (since  moved into the CRTU) the diabetes team have undertaken more than 60 research studies with industry, or externally funded with local and UK collaborators. The research team are highly experienced in clinical trial recruitment, GCP, participant retention, eCRF and database management, and in dealing with the regulatory pressures and obstacles in clinical research in the UK. We are aware of the intense recruitment pressures that many industry studies require, and are committed to realistic and accurate recruitment estimates, and have recruited to target in all industry and academic studies in the last decade.  Recruitment  sample sizes have ranged from up to 6,000 sample size for some studies (Norfolk Diabetes Study, UEA – IFG etc), with 10,000 planned for NDPS down to small  numbers in highly specialist trial recruitment and intense recruitment effort.  Recruitment locally is supported by excellent research working relationships with local practices individually and through PCRN support. The Consultant team are all research active and offer a range of expertise and research outputs and are Dr Ketan Dhatariya (clinical and research interest in DAFNE, foot disease, clinical therapeutics, and hypertension in diabetes), Dr Swe Myint (clinical and research interest in clinical therapeutics, obesity management, transitional care and hypertension management), Prof. Mike Sampson (PI or CI on most Norwich studies since 1995 , with £3.54M in external grant income in last 5 years from Diabetes UK or NIHR, and Deputy Lead East of England DRN), Dr Francesca Swords (Clinical Director, with a clinical and research interest in adrenal function, ACTH receptor function and pituitary disease and CLRN metabolic medicine co -  lead locally), Dr Rosemary Temple (clinical and research interest in preconception care and diabetes pregnancy), Dr Jeremy Turner  (clinical and research interest in obesity and adipose tissue inflammation with recent BHF and DRWF funding), Dr Tara Wallace (clinical and research interest in insulin resistance, insulin sensitivity and vascular risk and CSII). All provide internal cover and a pool of local co investigators. 

Therapeutic and Research Areas 

  • Obesity and adipose inflammation 

  • Metabolism, insulin sensitivity, hypertension

  • Paediatric care and insulin management and T1DM prevention

  • Retinopathy outcomes

  • Neuropathy management

  • T2DM prevention & Screening

  • Education (DAFNE and new patient education)

  • Clinical therapeutics, oral agents and insulin management in T2DM

  • Clinical therapeutics , oral agents and insulin management in T1DM

  • Diabetes Pregnancy management and outcomes

  • Foot disease management in diabetes

  • Nutrition, exercise and T2DM

  • Service Delivery

For more information contact Dr Jeremy Turner (jeremy.turner@nnuh.nhs.uk)