Understanding biological function Understanding biological function

We focus on the treatment of human disorders by a mechanistic understanding of cellular receptors and signalling pathways, with an emphasis on cancer, immunology and inflammation.

Our key research themes are inflammation in human diseases such as septic shock or retinitis, chemotaxis, cell-cell communication, carcinogenesis, antioxidant response and the cellular mechanisms underlying retinal damage and glaucoma.

Among the molecular targets being studied are G-protein coupled receptors, chemokine receptors, Nrf2 and the Wnt signalling pathway


Dr Anja Mueller

  • Chemokine receptor signalling mechanisms
  • G-protein-coupled receptor (GPCR) function
  • Cell migration in cancer and inflammation

Prof Maria O'Connell

  • Inflammatory gene control of macrophage and monocyte function
  • Control of antioxidant genes in normal and diseased states
  • Changes in inflammation processes in chronic inflammatory conditions such as septic shock

Dr Julie Sanderson

  • Cellular mechanisms underlying retinal ganglion cell neurodegeneration in glaucoma; identification of targets for neuroprotection
  • Involvement of purinergic signalling in ocular disease
  • Development of ex vivo human tissue models for study of ocular disease and ocular toxicology

Dr Anastasia Sobolewski

Dr Anatstasia Sobolewski

  • Stem cell-driven epithelial renewal in in the lung and gut
  • Immune cell (monocyte, macrophage, eosinophil)  regulation of epithelial renewal and regeneration in in health and inflammation
  • Epithelial regulation of immune cell function (monocyte, macrophage and eosinophil)

Dr Leanne Stokes

Dr Leanne Stokes

  • Purinergic receptor signaling pathways in immune cells
  • Pharmacology of purinergic ion channels
  • Inflammatory signalling in glial cells

Dr Derek Warren

Dr Derek Warren

  • Describing novel vascular smooth muscle cell mechanotransduction pathways
  • Understanding the relationship between extracellular matrix stiffness and cellular force generation
  • Interrogating the role of mechanotransduction in vascular disease progression