A selection of latest publications A selection of latest publications

The latest research publications and papers from within the school of Pharmacy.

Rac1 plays a role in CXCL12 but not CCL3-induced chemotaxis and Rac1 GEF inhibitor NSC23766 has off target effects on CXCR4.
Mills SC, Howell L, Beekman A, Stokes L, Mueller A. (2018)
Cell Signal. Jan;42:88-96.
DOI: 10.1016/j.cellsig.2017.10.006. Epub 2017 Oct 16.

Defining the role of the pharmacy technician and identifying their future role in medicines optimisation.
Boughen M, Sutton J, Fenn T, Wright D.* (2017)
Pharmacy. Jul 15;5(3). pii: E40.
DOI: 10.3390/pharmacy5030040.

Development of a core outcome set for effectiveness trials aimed at optimising prescribing in older adults in care homes.
Millar AN, Daffu-O'Reilly A, Hughes CM, Alldred DP, Barton G, Bond CM, Desborough JA, Myint PK, Holland R, Poland FM, Wright D; CHIPPS Team, University of East Anglia. (2017)
Trials. Apr 12;18(1):175.
DOI: 10.1186/s13063-017-1915-6.

Wright D, Begent D, Crawford H, Foundling Miah M, Griffith R, Merriman H.
Medication management of adults with swallowing difficulties.
Guidelines November 2017; Medendium Group Publishing Ltd.

Insight into Flufenamic Acid Cocrystal Dissolution in the Presence of a Polymer in Solution: from Single Crystal to Powder Dissolution.
Minshan Guo, Ke Wang, Ning Qiao, László Fábián, Ghazala Sadiq⊥, and Mingzhong Li (2017)
Mol. Pharmaceutics, 2017, 14 (12), pp 4583–4596
DOI: 10.1021/acs.molpharmaceut.7b00712

Marín-Menéndez, Alejandro; Montis, Costanza; Díaz-Calvo, Teresa; Carta, Davide; Hatzixanthis, Kostas; Morris, Christopher J; McArthur,Michael; Berti, Debora.
Antimicrobial Nanoplexes meet Model Bacterial Membranes: the key role of Cardiolipin. (2017).
Scientific Reports 7, Article number: 41242

Cadman, Brit; Wright, David; Bale, Amanda; Barton, Garry; Desborough, James; Hammad, Eman A; Holland, Richard; Howe, Helen; Nunney, Ian; Irvine, Lisa.
Pharmacist provided medicines reconciliation within 24 hours of admission and on discharge: a randomised controlled pilot study. (2017)
BMJ Open, 7:e013647
DOI: 10.1136/bmjopen-2016-013647

Twigg MJ, Wright D, Kirkdale CL, Desborough JA, Thornley T.
The UK Pharmacy Care Plan service: Description, recruitment and initial views on a new community pharmacy intervention. (2017)
PLoS ONE 12(4): e0174500.
DOI: 10.1371/journal.pone.0174500

Alhijjaj M, Belton P, Qi S.
An investigation into the use of polymer blends to improve the printability of and regulate drug release from pharmaceutical solid dispersions prepared via fused deposition modeling (FDM) 3D printing. (2016)
Eur. J. Pharm & Biopharm., 108, pp 111–125,
DOI: 10.1016/j.ejpb.2016.08.016

Bowman, Kate A.; Aarstad, Olav Andreas; Nakamura, Marcela; Stokke, Bjørn Torger; Skjåk-bræk, Gudmund; Round, Andrew N. (Lead Author).
Single molecule investigation of the onset and minimum size of the calcium-mediated junction zone in alginate (2016)
Carbohydrate Polymers, 148, p. 52-60.
DOI: 10.1016/j.carbpol.2016.04.043

Qi, Sheng; Craig, Duncan.
Recent developments in micro- and nanofabrication techniques for the preparation of amorphous pharmaceutical dosage forms (2016)
Advanced Drug Delivery Reviews, 100, p. 67-84.
DOI: 10.1016/j.addr.2016.01.003

Yang, Xiao (Lead Author); Ding, Yanping; Ji, Tianjiao; Zhao, Xiao; Wang, Hai; Zhao, Xiaozheng; Zhao, Ruifang; Wei, Jingyan; Qi, Sheng; Nie, Guangjun.
Improvement of the in vitro safety profile and cytoprotective efficacy of amifostine against chemotherapy by PEGylation strategy (2016)
Biochemical Pharmacology, 108, p. 11-21.
DOI: 10.1016/j.bcp.2016.02.014

Ulaeto, David O.; Morris, Christopher J.; Fox, Marc A.; Gumbleton, Mark; Beck, Konrad.
Destabilization of α-helical structure in solution improves bactericidal activity of antimicrobial peptides: Opposing effects on bacterial and viral targets (2016)
Antimicrobial Agents and Chemotherapy, 60, 4, p. 1984-1991.
DOI: 10.1128/AAC.02146-15

Mills, Shirley C.; Goh, Poh Hui; Kudatsih, Jossie; Ncube, Sithembile; Gurung, Renu; Maxwell, Will; Mueller, Anja.
Cell migration towards CXCL12 in leukemic cells compared to breast cancer cells (2016)
Cellular Signalling, 28, 4, p. 316-324.
DOI: 10.1016/j.cellsig.2016.01.006

Navarro, Gemma; Cordomi, Arnau; Zelman- Femiak, Monika; Moreno, Estefania; Brugarolas, Marc; Aguinaga, David; Pérez-Benito, Laura; Cortes, Antonio; Casadó, Vicent; Mallol, Josefa; Canela, Enric Isidre; Lluis, Carmen; Pardo, Leonardo; Jesus García-Sáez, Ana; McCormick, Peter James (Lead Author); Franco, Rafael (Lead Author).
Quaternary structure of a G-protein coupled receptor heterotetramer in complex with Gi and Gs (2016)
BMC Biology, 14, 26
DOI: 10.1186/s12915-016-0247-4

Navarro, Gemma; Aguinaga, David; Angelats, Edgar; Medrano, Mireia; Moreno, Estefania; Mallol, Josefa; Cortes, Antonio; Canela, Enric I; Casado, Vicent; McCormick, Peter J; Lluis, Carme; Ferre, Sergi.
Significant role of the truncated Ghrelin Receptor GHS-1Rb in Ghrelin-induced signaling in neurons (2016)
Journal of Biological Chemistry, 291, p. 13048-13062.
DOI: 10.1074/jbc.M116.715144

Scarselli, Marco; Annibale, Paolo; McCormick, Peter J; Kolachalam, Shivakumar; Aringhieri, Stefano; Radenovic, Aleksandra; Corsini, Giovanni U; Maggio, Roberto.
Revealing G-protein-coupled receptor oligomerization at the single-molecule level through a nanoscopic lens : methods, dynamics and biological function (2016)
FEBS Journal, 283, 7, p. 1197-1217.
DOI: 10.1111/febs.13577

Rashid, Abdul M.; Batey, Sibyl F. D.; Syson, Karl; Koliwer-Brandl, Hendrik; Miah, Farzana; Barclay, J. Elaine; Findlay, Kim C.; Nartowski, Karol P.; Khimyak, Yaroslav Z.; Kalscheuer, Rainer; Bornemann, Stephen.
Assembly of α-Glucan by GlgE and GlgB in Mycobacteria and Streptomycetes (2016)
Biochemistry, 55, 23, p. 3270-3284.
DOI: 10.1021/acs.biochem.6b00209

Beekman, Andrew M.; O'Connell, Maria A.; Howell, Lesley A.
Identification of Small-Molecule Inhibitors of the Antiapoptotic Protein Myeloid Cell Leukaemia-1 (Mcl-1) (2016)
ChemMedChem, 11, 8, p. 840–844.
DOI: 10.1002/cmdc.201500488

Kay, Kristine L.; Hamilton, Chris J.; Le Brun, Nick E.
Mass spectrometry of B. subtilis CopZ: Cu(I)-binding and interactions with bacillithiol (2016)
Metallomics, 8, 7, p. 709-719.
DOI: 10.1039/C6MT00036C

Shaheen, Farzana (Lead Author); Jabeen, Almas; Ashraf, Samreen; Nadeem-ul- Haque, Muhammad; Ali Shah, Zafar; Asad Ziaee, Muhammad; Dastagir, Nida; Ganesan, A.
Total synthesis, structural, and biological evaluation of stylissatin A and related analogs (2016)
Journal of Peptide Science, 22, 9, p. 607-617.
DOI: 10.1002/psc.2909

Ganesan, A.
Multitarget Drugs: an Epigenetic Epiphany (2016)
ChemMedChem, 11, 12, p. 1227-1241
DOI: 10.1002/cmdc.201500394