A selection of latest publications A selection of latest publications

The latest research publications and papers from within the school of Pharmacy.

Marín-Menéndez, Alejandro; Montis, Costanza; Díaz-Calvo, Teresa; Carta, Davide; Hatzixanthis, Kostas; Morris, Christopher J; McArthur,Michael; Berti, Debora.
Antimicrobial Nanoplexes meet Model Bacterial Membranes: the key role of Cardiolipin. (2017).
Scientific Reports 7, Article number: 41242
DOI:10.1038/srep41242

Cadman, Brit; Wright, David; Bale, Amanda; Barton, Garry; Desborough, James; Hammad, Eman A; Holland, Richard; Howe, Helen; Nunney, Ian; Irvine, Lisa.
Pharmacist provided medicines reconciliation within 24 hours of admission and on discharge: a randomised controlled pilot study. (2017)
BMJ Open, 7:e013647
DOI: 10.1136/bmjopen-2016-013647

Twigg MJ, Wright D, Kirkdale CL, Desborough JA, Thornley T.
The UK Pharmacy Care Plan service: Description, recruitment and initial views on a new community pharmacy intervention. (2017)
PLoS ONE 12(4): e0174500.
DOI: 10.1371/journal.pone.0174500

Alhijjaj M, Belton P, Qi S.
An investigation into the use of polymer blends to improve the printability of and regulate drug release from pharmaceutical solid dispersions prepared via fused deposition modeling (FDM) 3D printing. (2016)
Eur. J. Pharm & Biopharm., 108, pp 111–125,
DOI: 10.1016/j.ejpb.2016.08.016

Bowman, Kate A.; Aarstad, Olav Andreas; Nakamura, Marcela; Stokke, Bjørn Torger; Skjåk-bræk, Gudmund; Round, Andrew N. (Lead Author).
Single molecule investigation of the onset and minimum size of the calcium-mediated junction zone in alginate (2016)
Carbohydrate Polymers, 148, p. 52-60.
DOI: 10.1016/j.carbpol.2016.04.043

Qi, Sheng; Craig, Duncan.
Recent developments in micro- and nanofabrication techniques for the preparation of amorphous pharmaceutical dosage forms (2016)
Advanced Drug Delivery Reviews, 100, p. 67-84.
DOI: 10.1016/j.addr.2016.01.003

Yang, Xiao (Lead Author); Ding, Yanping; Ji, Tianjiao; Zhao, Xiao; Wang, Hai; Zhao, Xiaozheng; Zhao, Ruifang; Wei, Jingyan; Qi, Sheng; Nie, Guangjun.
Improvement of the in vitro safety profile and cytoprotective efficacy of amifostine against chemotherapy by PEGylation strategy (2016)
Biochemical Pharmacology, 108, p. 11-21.
DOI: 10.1016/j.bcp.2016.02.014

Ulaeto, David O.; Morris, Christopher J.; Fox, Marc A.; Gumbleton, Mark; Beck, Konrad.
Destabilization of α-helical structure in solution improves bactericidal activity of antimicrobial peptides: Opposing effects on bacterial and viral targets (2016)
Antimicrobial Agents and Chemotherapy, 60, 4, p. 1984-1991.
DOI: 10.1128/AAC.02146-15

Mills, Shirley C.; Goh, Poh Hui; Kudatsih, Jossie; Ncube, Sithembile; Gurung, Renu; Maxwell, Will; Mueller, Anja.
Cell migration towards CXCL12 in leukemic cells compared to breast cancer cells (2016)
Cellular Signalling, 28, 4, p. 316-324.
DOI: 10.1016/j.cellsig.2016.01.006

Navarro, Gemma; Cordomi, Arnau; Zelman- Femiak, Monika; Moreno, Estefania; Brugarolas, Marc; Aguinaga, David; Pérez-Benito, Laura; Cortes, Antonio; Casadó, Vicent; Mallol, Josefa; Canela, Enric Isidre; Lluis, Carmen; Pardo, Leonardo; Jesus García-Sáez, Ana; McCormick, Peter James (Lead Author); Franco, Rafael (Lead Author).
Quaternary structure of a G-protein coupled receptor heterotetramer in complex with Gi and Gs (2016)
BMC Biology, 14, 26
DOI: 10.1186/s12915-016-0247-4

Navarro, Gemma; Aguinaga, David; Angelats, Edgar; Medrano, Mireia; Moreno, Estefania; Mallol, Josefa; Cortes, Antonio; Canela, Enric I; Casado, Vicent; McCormick, Peter J; Lluis, Carme; Ferre, Sergi.
Significant role of the truncated Ghrelin Receptor GHS-1Rb in Ghrelin-induced signaling in neurons (2016)
Journal of Biological Chemistry, 291, p. 13048-13062.
DOI: 10.1074/jbc.M116.715144

Scarselli, Marco; Annibale, Paolo; McCormick, Peter J; Kolachalam, Shivakumar; Aringhieri, Stefano; Radenovic, Aleksandra; Corsini, Giovanni U; Maggio, Roberto.
Revealing G-protein-coupled receptor oligomerization at the single-molecule level through a nanoscopic lens : methods, dynamics and biological function (2016)
FEBS Journal, 283, 7, p. 1197-1217.
DOI: 10.1111/febs.13577

Rashid, Abdul M.; Batey, Sibyl F. D.; Syson, Karl; Koliwer-Brandl, Hendrik; Miah, Farzana; Barclay, J. Elaine; Findlay, Kim C.; Nartowski, Karol P.; Khimyak, Yaroslav Z.; Kalscheuer, Rainer; Bornemann, Stephen.
Assembly of α-Glucan by GlgE and GlgB in Mycobacteria and Streptomycetes (2016)
Biochemistry, 55, 23, p. 3270-3284.
DOI: 10.1021/acs.biochem.6b00209

Beekman, Andrew M.; O'Connell, Maria A.; Howell, Lesley A.
Identification of Small-Molecule Inhibitors of the Antiapoptotic Protein Myeloid Cell Leukaemia-1 (Mcl-1) (2016)
ChemMedChem, 11, 8, p. 840–844.
DOI: 10.1002/cmdc.201500488

Kay, Kristine L.; Hamilton, Chris J.; Le Brun, Nick E.
Mass spectrometry of B. subtilis CopZ: Cu(I)-binding and interactions with bacillithiol (2016)
Metallomics, 8, 7, p. 709-719.
DOI: 10.1039/C6MT00036C

Shaheen, Farzana (Lead Author); Jabeen, Almas; Ashraf, Samreen; Nadeem-ul- Haque, Muhammad; Ali Shah, Zafar; Asad Ziaee, Muhammad; Dastagir, Nida; Ganesan, A.
Total synthesis, structural, and biological evaluation of stylissatin A and related analogs (2016)
Journal of Peptide Science, 22, 9, p. 607-617.
DOI: 10.1002/psc.2909

Ganesan, A.
Multitarget Drugs: an Epigenetic Epiphany (2016)
ChemMedChem, 11, 12, p. 1227-1241
DOI: 10.1002/cmdc.201500394

Davidson, Sean M.; Foote, Kirsty; Kunuthur, Suma; Gosain, Raj; Tan, Noah; Tyser, Richard; Zhao, Yong Juan; Graeff, Richard; Ganesan, A.; Duchen, Michael R.; Patel, Sandip; Yellon, Derek M.
Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore (2016)
Cardiovascular Research, 108, 3, p. 357-366.
DOI: 10.1093/cvr/cvv226

Nartowski, Karol; Malhotra, Diksha; Hawarden, Lucy; Sibik, Juraj; Iuga, Dinu; Zeitler, J. Axel; Fabian, Laszlo; Khimyak, Yaroslav.
19F NMR Spectroscopy as a Highly Sensitive Method for the Direct Monitoring of Confined Crystallization within Nanoporous Materials (2016)
Angewandte Chemie International Edition, 128, 31, p. 9050-9054.
DOI: 10.1002/anie.201602936

Jee, Samuel; Grimes, Lesley; Desborough, James; Cutts, Christopher.
The national consultation skills for pharmacy practice program in England (2016)
Currents in Pharmacy Teaching and Learning, 8, 3, p. 442-446.
DOI: 10.1016/j.cptl.2016.02.020

Andreassen, Lillan Mo; Kjome, Reidun Lisbet Skeide; Sølvik, Una Ørvim; Houghton, Julie; Desborough, James Antony.
The potential for deprescribing in care home residents with Type 2 diabetes (2016)
International Journal of Clinical Pharmacy, 38, p. 977–984.
DOI: 10.1007/s11096-016-0323-4

Watson, Steven James; Aldus, Clare Frances; Bond, Christine; Bhattacharya, Debi.
Systematic review of the health and societal effects of medication organisation devices (2016)
BMC Health Services Research, 16, 202
DOI: 10.1186/s12913-016-1446-y

Behray, Mehrnaz; Webster, Carl A; Pereira, Sara; Ghosh, Paheli; Krishnamurthy, Satheesh; Al-Jamal, Wafa T; Chao, Yimin.
Synthesis of Diagnostic Silicon Nanoparticles for Targeted Delivery of Thiourea to Epidermal Growth Factor Receptor-Expressing Cancer Cells (2016)
ACS Applied Materials & Interfaces, 8, 14, p. 8908–8917.
DOI: 10.1021/acsami.5b12283

Bhattacharya, D (Lead Author); Aldus, CF; Barton, G; Bond, CM; Boonyaprapa, S; Charles, IS; Fleetcroft, R; Holland, R; Jerosch- Herold, C; Salter, C; Shepstone, L; Walton, C; Watson, S; Wright, DJ.
The feasibility of determining the effectiveness and cost-effectiveness of medication organisation devices compared with usual care for older people in a community setting: systematic review, stakeholder focus groups and feasibility randomised controlled trial (2016)
Health Technology Assessment, 20, 50
DOI: 10.3310/hta20500

Unwin H, Wright D, Twigg MJ, McGough N; (2016)
Early recognition of coeliac disease through community pharmacies: A proof of concept study
International Journal of Clinical Pharmacy (accepted)
DOI: 10.1007/s11096-016-0368-4

Twigg MJ, Thornley T, Scobie N; (2016)
Identification of patients with atrial fibrillation in UK community pharmacy: an evaluation of a new service
International Journal of Clinical Pharmacy 38; 784
DOI: 10.1007/s11096-016-0303-8

Twigg MJ, Lupattelli A., Nordeng H; (2016)
Women’s beliefs about medication use during pregnancy: a UK perspective
International Journal of Clinical Pharmacy 38; 968
DOI: 10.1007/s11096-016-0322-5

Wright D & Twigg MJ (2016)
Community pharmacy: an untapped patient data resource
Integrated Pharmacy Research and Practice 5; 19-25
DOI: 10.2147/IPRP.S83261

Twigg MJ, Bhattacharya D, Clark A, Patel R, Rogers H, Whiteside H, Yaqoob M, Wright D. (2016)
What do patients need to know? A study to assess patients’ satisfaction with information about medicines
International Journal of Pharmacy Practice 24 (4) 229 - 236
DOI: 10.1111/ijpp.12252

Alhijjaja M, Belton P, Qi S (2016)
An investigation into the use of polymer blends to improve the printability of and regulate drug release from pharmaceutical solid dispersions prepared via fused deposition modeling (FDM) 3D printing
European Journal of Pharmaceutics and Biopharmaceutics, in press
DOI: 10.1016/j.ejpb.2016.08.016

Buffet, K., Nierengarten, I., Galanos, N., Gillon, E., Holler, M., Imberty, A., Matthews, S. E., Vidal, S., Vincent, S. P., Nierengarten, J. (2016)
Pillar[5]arene-based glycoclusters: synthesis and multivalent binding to pathogenic bacterial lectins
Chemistry - A European Journal, 22.pp. 2955-2963
DOI: 10.1002/chem.201504921

Warner, E. F., Zhang, Q., Raheem, K. S., O'Hagan, D., O'Connell, M. A., Kay, C. D. (2016)
Common Phenolic Metabolites of Flavonoids, but Not Their Unmetabolized Precursors, Reduce the Secretion of Vascular Cellular Adhesion Molecules by Human Endothelial Cells
Journal of Nutrition 146. pp. 465-473
DOI:  10.3945/jn.115.217943

Howell, L., Beekman, A. (2016)
Small molecule and peptide inhibitors of the pro-survival protein Mcl-1
ChemMedChem, online
DOI: 10.1002/cmdc.201500497

Guzzi, C., Alfarano, P., Sutkeviciute, I., Sattin, S., Ribeiro-viana, R., Fieschi, F., Bernardi, A., Weiser, J., Rojo, J., Angulo, J., Nieto, P. M. (2016)
Detection and Quantitative Analysis of Two Independent Binding Modes of a Small Ligand Responsible for DC-SIGN Clustering
Organic & Biomolecular Chemistry 14. pp. 335-344
DOI: 10.1039/C5OB02025E

Tipduangta, P., Belton, P., Fabian, L., Wang, L. Y., Tang, H., Eddledton, M., Qi, S. (2016)
Electrospun polymer blend nanofibers for tuneable drug delivery: the role of transformative phase separation on controlling the release rate
Molecular Pharmaceutics 13. pp. 40-46
DOI: 10.1021/acs.molpharmaceut.5b00359