A selection of latest publications A selection of latest publications

The latest research publications and papers from within the school of Pharmacy.

Bidula, S., Dhuna, K., Helliwell, R. & Stokes, L.
Positive allosteric modulation of P2X7 promotes apoptotic cell death over lytic cell death responses in macrophages.
Oct 2019, (Accepted)
Cell Death & Disease

Ritchie, H., Saini, B., Twigg, M. & Kennedy, D.
Utilisation of a NSW Teratology Information Service by pharmacists and patients referred by a pharmacist from 2000 – 2018.
Oct 2019
The Australian and New Zealand Journal of Obstetrics and Gynaecology.

Dann-Reed, E., Poland, F. & Wright, D.
Systematic review to inform the development of a community pharmacy based intervention for people affected by dementia.
Oct 2019
International Journal of Pharmacy Practice.

Muñoz-García, J. C., Corbin, K. R., Hussain, H., Gabrielli, V., Koev, T., Iuga, D., Round, A. N., Mikkelsen, D., Gunning, P. A., Warren, F. J. & Khimyak, Y. Z.
High Molecular Weight Mixed-Linkage Glucan as a Mechanical and Hydration Modulator of Bacterial Cellulose: Characterization by Advanced NMR Spectroscopy.
Sep 2019
Biomacromolecules (epub)

Bell, A., Brunt, J., Crost, E., Vaux, L., Nepravishta, R., Owen, D., Latousakis, D., Xiao, A., Li, W., Chen, X., Walsh, M. A., Claesen, J., Angulo, J., Thomas, G. H. & Juge, N.
Elucidation of a novel sialic acid metabolism pathway in mucusforaging bacteria unravels mechanisms of adaptation to the gut.
Sep 2019, (Accepted/In press)
Nature Microbiology.

Scott, S., Twigg, M., Clark, A., Farrow, C., May, H., Patel, M., Taylor, J., Wright, D. & Bhattacharya, D.
Development of a hospital Deprescribing Implementation Framework: A focus group study with geriatricians and Pharmacists.
Sep 2019, (Accepted/In press)
Age and Ageing.

Bibic, L., Herzig, V., King, G. & Stokes, L.
Development of High-Throughput Fluorescent-Based Screens to Accelerate Discovery of P2X Inhibitors from Animal Venoms.
Sep 2019
Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00410

Bell, A., Brunt, J., Crost, E., Vaux, L., Nepravishta, R., Owen, D., Latousakis, D., Xiao, A., Li, W., Chen, X., Walsh, M. A., Claesen, J., Angulo, J., Thomas, G. H. & Juge, N.,
Elucidation of a novel sialic acid metabolism pathway in mucusforaging bacteria unravels mechanisms of adaptation to the gut.
Sep 2019, (Accepted/In press)
Nature Microbiology.

Ruiz, A., Alpízar, A., Beola, L., Rubio, C., Gavilán, H., Marciello, M., Rodriguez Ramiro, I., Ciordia, S., Morris, C. & del Puerto Morales, M.
Understanding the Influence of a Bifunctional Polyethylene Glycol Derivative in Protein Corona Formation around Iron Oxide Nanoparticles
Materials. 12, 14, 2218,10 Jul 2019
DOI: 10.3390/ma12142218

Saeed, A. & Dominguez Falcon, N.
Investigation into the effect of BMP-12 and TGF-1 on stimulation of tenogenic markers in serum-free cultured human adipose-derived stem cells (ADSCs).
June 2019

Bibic, L., Druskis, J., Walpole, S., Angulo Alvarez, J. & Stokes, L.
Bug Off Pain: An Educational Virtual Reality Game on Spider Venoms and Chronic Pain for Public Engagement
Journal of Chemical Education. May 2019
DOI: 10.1021/acs.jchemed.8b00905

Bibic, L
Spongy yet Sturdy: MOF Harvests water from air.
Journal of the American Chemical Society. 141, p. 4775. Mar 2019

Pigliacelli, C., Belton, P., Wilde, P. & Qi, S
Probing the Molecular Interactions between Pharmaceutical Polymeric Carriers and Bile Salts in Simulated Gastrointestinal Fluids using NMR Spectroscopy.
Journal of Colloid, May 2019
DOI: 10.1016/j.jcis.2019.05.002

Falcon, N. D., Riley, G. & Saeed, A.
Induction of Tendon-Specific Markers in Adipose-Derived Stem Cells in Serum-Free Culture.
(Accepted/In press) Tissue Engineering. Part C, Methods. May 2019

Smith R, Weekes H, Morgan, L, Parkes M, Lee JC.
Tacrolimus suppositories: a safe and effective treatment for treatment-refractory proctitis (A-1951).
14th ECCO, Copenhagen, Denmark.  March 2019

Bidula, Stefan M., Cromer, Brett A., Walpole, Samuel., Angulo, Jesus, Stokes, Leanne.
Mapping a novel positive allosteric modulator binding site in the central vestibule region of human P2X7. (2019)
Scientific Reports volume 9, Article number: 3231

González-Paredes A, Sitia L, Ruyra A, Morris CJ, Wheeler GN, McArthur M, Gasco P.
Solid lipid nanoparticles for the delivery of anti-microbial oligonucleotides. (2019)
Eur J Pharm Biopharm. 134:166-177.
DOI: 10.1016/j.ejpb.2018.11.017. Epub 2018 Nov 20.

Dhuna, Kshitija., Felgate, Matthew., Bidula, Stefan M., Walpole, Samuel., Bibic, Lucka., Cromer, Brett A., Angulo, Jesus., Sanderson, Julie., Stebbing, Martin J and Stokes, Leanne.
Ginsenosides act as positive modulators of P2X4 receptors. 2018
Molecular Pharmacology, mol.118.113696;
DOI: 10.1124/mol.118.113696

Morgan L.
Problematic Polypharmacy: when to stop prescribing>. Nov 2018.
Nursing and Residential Care.  20:11

Liso, M., De Santis, S., Scarano, A., Verna, G., Dicarlo, M., Galleggiante, V., Campiglia, P.,  Mastronardi, M., Lippolis, A., Vacca, M., Sobolewski, A., Serino, G., Butelli, E., De Angelis, M.,
Martin, C., Santino, A. & Chieppa, M.
A Bronze-Tomato Enriched Diet Affects the Intestinal Microbiome under Homeostatic and Inflammatory Conditions. (2018)
In: Nutrients. 10, 12, 1862
DOI: 10.3390/nu10121862

Carro, L.
Protein–protein interactions in bacteria: a promising and challenging avenue towards the discovery of new antibiotics. (2018)
In : Beilstein Journal of Organic Chemistry. 14, p. 2881-2896
DOI: 10.3762/bjoc

Katangwe, T., Bhattacharya, D. & Twigg, M. (2018)
A systematic review exploring characteristics of lifestyle modification interventions in newly diagnosed type 2 diabetes for delivery in community pharmacy.
(Accepted/In press) In : International Journal of Pharmacy Practice

Redox Modulation at Work: Natural Phytoprotective Polysulfanes From Alliums Based on Redox-Active Sulfur. (2018)
Anwar, A., Gould, E., Tinson, R., Iqbal, J. & Hamilton, C.
In : Current Pharmacology Reports. 4, 5, p. 397–407
DOI: 10.1007/s40495-018-0153-2

Nartowski, K., Malhotra, D., Hawarden, L., Fabian, L. & Khimyak, Y.
Nanocrystallization of Rare Tolbutamide Form V in Mesoporous MCM-41 Silica. (2018)
In : Molecular Pharmaceutics.
DOI: 10.1021/acs.molpharmaceut.8b00575

Kay, K. L., Hamilton, C. J. & Le Brun, N. E.
Mass spectrometric studies of Cu(I)-binding to the Nterminal domains of B. subtilis CopA and influence of bacillithiol. (2018)
In : Journal of Inorganic Biochemistry. 190, p. 24-30
DOI: 10.1016/j.jinorgbio.2018.10.004

Easthall, C., Taylor, N. & Bhattacharya, D.
Barriers to medication adherence in patients prescribed medicines for the prevention of cardiovascular disease: a conceptual framework. (2018)
In : International Journal of Pharmacy Practice.
DOI: 10.1111/ijpp.12491

Alhijjaj, M., Belton, P., Fabian, L., Wellner, N., Reading, M. & Qi, S.
A novel thermal imaging method for rapid screening of drug-polymer miscibility for solid dispersion based formulation development. (2018)
In : Molecular Pharmaceutics.
DOI: 10.1021/acs.molpharmaceut.8b00798

Abdelhamid, M. A. S., Gates, A. J. & Waller, Z. A. E.
Destabilization of i-Motif DNA at Neutral pH by GQuadruplex Ligands. (2018)
DOI: 10.1021/acs.biochem.8b00968

Wright, D., Scott, S., Buck, J. & Bhattacharya, D.
Roles of nurses in supporting proactive deprescribing. (2018)
(Accepted/In press) In: Nursing Standard.

R., Rejzek, M., Wegmann, U., Le Gall, G., Kavanaugh, D. W., Colquhoun, I., Frese, S., MacKenzie, D. A., Walter, J., Angulo, J., Field, R. & Juge, N.
Serine-Rich Repeat Protein adhesins from Lactobacillus reuteri display strain specific glycosylation profiles Latousakis, D., Nepravishta.(2018)
(Accepted/In press) In : Glycobiology.
DOI: 10.1093/glycob/cwy100

Brown, T. J., Twigg, M., Taylor, N., Easthall, C., Hartt, J., Budd, T., Li, Z., Dima, A. & Bhattacharya, D.
Final Report for the IMAB-Q study: Validation and Feasibility Testing of a Novel Questionnaire to Identify Barriers to Medication Adherence. (2018)
Pharmacy Research UK.

Scott, S., Clark, A., May, H.& Bhattacharya, D.
Validation and Feasibility of the Medication Acceptability Questionnaire to Investigate Tablet and Liquid Alendronic Acid with Older Hospital Patients. (2018)
Pharmacy. 6, 11 p., 84
DOI: 10.3390/pharmacy6030084.

Craske, M., Wright, D., Blacklock, J., Matthews, H., Dean, T., Farrow, T., Daly, C. & Duell, P.
Testing annual asthma reviews for those who fail to attend: proof-of-concept study. (2018)
The Pharmaceutical Journal. 8, 10, p. 243-249 7 p.

Calabrese, V., da Silva, M. A., Schmitt, J., Muñoz- Garcia, J. C., Gabrielli, V., Scott, J. L., Angulo, J., Khimyak, Y. Z. & Edler, K. J.
Surfactant controlled zwitterionic cellulose nanofibril dispersions. (2018)
Soft Matter.
DOI: 10.1039/C8SM00752G

Abdelhamid, M. A. S., Fábián, L., MacDonald, C. J., Cheesman, M. R., Gates, A. J. & Waller, Z. A. E.
Redox-dependent control of i-Motif DNA structure using copper cations. (2018)
Nucleic Acids Research.
DOI: 10.1093/nar/gky390

Nasereddin, J. M., Wellner, N., Alhijjaj, M., Belton, P., Qi, S.
Development of a Simple Mechanical Screening Method for Predicting the Feedability of a Pharmaceutical FDM 3D Printing Filament. (2018)
Pharmaceutical Research 35 (8) article no. 151
DOI: 10.1007/s11095-018-2432-3

Twigg M, Wright D, Barton G, Kirkdale CL, Thornley T.
The pharmacy care plan service: Service evaluation and estimate of cost-effectiveness. (2018)
Research in Social & Administrative Pharmacy. PII: S1551-7411(17)30838-0 
DOI: 10.1016/j.sapharm.2018.03.062

Abdelhamid, MAS, Fábián, L, MacDonald, CJ, Cheesman, MR, Gates, Zoë AE Waller.
Redox-dependent control of i-Motif DNA structure using copper cations. (2018)
Nucleic Acids Research, gky390,
DOI: 10.1093/nar/gky390

Marín-Barba M, Gavilán H, Gutiérrez L, Lozano-Velasco E, Rodríguez-Ramiro I, Wheeler GN, Morris CJ, Morales MP, Ruiz A.
Unravelling the mechanisms that determine the uptake and metabolism of magnetic single and multicore nanoparticles in a Xenopus laevis model (2018).
Nanoscale. Jan 3;10(2):690-704.
DOI: 10.1039/C7NR06020C.