A selection of latest publications A selection of latest publications

The latest research publications and papers from within the school of Pharmacy.

Silva VL, Kaassis A, Dehsorkhi A, Koffi CR, Severic M, Abdelhamid M, Nyimanu D, Morris CJ, Al-Jamal WT.
Enhanced selectivity, cellular uptake, and in vitro activity of an intrinsically fluorescent copper-tirapazamine nanocomplex for hypoxia targeted therapy in prostate cancer.
Biomater Sci. 2020 Apr 1.
DOI: 10.1039/c9bm01905g

Abdelhamid, M. & Waller, Z.
Tricky Topology: Persistence of Folded Human Telomeric i-Motif DNA at Ambient Temperature and Neutral pH.
2020
Frontiers in Chemistry. 8, 6 p., 40.
DOI: 10.3389/fchem.2020.00040

Alqahtani, F., Belton, P., Ward, A.
An investigation into the use of low quantities of functional additives to control drug release from hot melt extruded solid dispersions for poorly soluble drug delivery.
Asare-Addo, K. & Qi, S.
2020
International Journal of Pharmaceutics.
DOI: 10.1016/j.ijpharm.2020.119172

Ohsawa, K., Zhao, H., Tokunaga, T., Thomas, C., Ganesan, A., Masuda, Y. & Doi, T.
Stereoselective Synthesis of Protected l-allo-Enduracididine and l- Enduracididine via Asymmetric Nitroaldol Reaction.
2019
Synthesis 52(06): 942-948.

Sophocleous, R. A., Berg, T., Finol‐ Urdaneta, R. K., Sluyter, V., Keshiya, S., Bell, L., Curtis, S. J., Curtis, B. L., Seavers, A., Bartlett, R., Dowton, M., Stokes, L., Ooi, L. & Sluyter, R.
Pharmacological and genetic characterisation of the canine P2X4 receptor.
2020
British Journal of Pharmacology.
DOI: 10.1111/bph.15009

Evans, G. & Wright, D.
Long-term evaluation of a UK Community Pharmacy-Based Weight Management Service.
2020
Pharmacy. 8, 14 p., 22.
DOI: 10.3390/pharmacy8010022

Wright, D., Smithard, D. & Griffith, R.,
Optimising medicines administration for patients with dysphagia in hospital: Medical or nursing responsibility?
2020
Geriatrics. 5, 10 p.,9.
DOI: 10.3390/geriatrics5010009.

Liao, X., Falcon, N. D., Mohammed, A. A., Paterson, Y. Z., Mayes, A. G., Guest, D. J. & Saeed, A.
Synthesis and Formulation of Four-Arm PolyDMAEA-siRNA Polyplex for Transient Downregulation of Collagen Type III Gene Expression in TGF-β1 Stimulated Tenocyte Culture.
2020
ACS Omega. 5, 3, p. 1496-1505 10 p.

Hydrophobization of cellulose nanocrystals for aqueous colloidal suspensions and gels.
Nigmatullin, R., Johns, M. A., Munoz Garcia, J., Gabrielli, V., Schmitt, J., Angulo, J., Khimyak, Y., Scott, J. L., Edler, K. J. & Eichhorn, S. J.
2020
Biomacromolecules.
DOI: 10.1021/acs.biomac.9b01721

Aldholmi, M., Marchand, P., Ourliac-Garnier, I., Le Pape, P. & Ganesan, A.
A Decade of Antifungal Leads from Natural Products: 2010-2019
2020
Pharmaceuticals. 12, 4
DOI: 10.3390/ph12040182

Mohammad J. Akbar, Pâmela C. Lukasewicz Ferreira, Melania Giorgetti, Leanne Stokes and Christopher J. Morris*.
Bombesin receptor-targeted liposomes for enhanced delivery to lung cancer cells.
Beilstein J. Nanotechnol. 2019, 10, 2553-2562
DOI: 10.3762/bjnano.10.246

Jayna J. Mistry, Christopher R. Marlein, Jamie A. Moore, Charlotte Hellmich, Edyta E. Wojtowicz, James G. W. Smith, Iain Macaulay, Yu Sun, Adam Morfakis, Angela Patterson, Rebecca H. Horton, Devina Divekar, Christopher J. Morris, Anna Haestier, Federica Di Palma, Naiara Beraza, Kristian M. Bowles, and Stuart A. Rushworth.
ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infection.
PNAS, 2019 116 (49) 24610-24619;
DOI: doi.org/10.1073/pnas.1913278116

Zhang, Y., Yang, M., Duncan, S., Yang, X.,  Abdelhamid, MAS., Huang, L., Zhang, H., Benfey, PN., Waller, ZAE., Ding, Y.
G-quadruplex structures trigger RNA phase separation.
November 2019
Nucleic Acids Research, gkz978,
DOI: 10.1093/nar/gkz978

Bidula, S., Dhuna, K., Helliwell, R. & Stokes, L.
Positive allosteric modulation of P2X7 promotes apoptotic cell death over lytic cell death responses in macrophages.
Oct 2019, (Accepted)
Cell Death & Disease

Ritchie, H., Saini, B., Twigg, M. & Kennedy, D.
Utilisation of a NSW Teratology Information Service by pharmacists and patients referred by a pharmacist from 2000 – 2018.
Oct 2019
The Australian and New Zealand Journal of Obstetrics and Gynaecology.

Dann-Reed, E., Poland, F. & Wright, D.
Systematic review to inform the development of a community pharmacy based intervention for people affected by dementia.
Oct 2019
International Journal of Pharmacy Practice.

Muñoz-García, J. C., Corbin, K. R., Hussain, H., Gabrielli, V., Koev, T., Iuga, D., Round, A. N., Mikkelsen, D., Gunning, P. A., Warren, F. J. & Khimyak, Y. Z.
High Molecular Weight Mixed-Linkage Glucan as a Mechanical and Hydration Modulator of Bacterial Cellulose: Characterization by Advanced NMR Spectroscopy.
Sep 2019
Biomacromolecules (epub)

Bell, A., Brunt, J., Crost, E., Vaux, L., Nepravishta, R., Owen, D., Latousakis, D., Xiao, A., Li, W., Chen, X., Walsh, M. A., Claesen, J., Angulo, J., Thomas, G. H. & Juge, N.
Elucidation of a novel sialic acid metabolism pathway in mucusforaging bacteria unravels mechanisms of adaptation to the gut.
Sep 2019, (Accepted/In press)
Nature Microbiology.

Scott, S., Twigg, M., Clark, A., Farrow, C., May, H., Patel, M., Taylor, J., Wright, D. & Bhattacharya, D.
Development of a hospital Deprescribing Implementation Framework: A focus group study with geriatricians and Pharmacists.
Sep 2019, (Accepted/In press)
Age and Ageing.

Bibic, L., Herzig, V., King, G. & Stokes, L.
Development of High-Throughput Fluorescent-Based Screens to Accelerate Discovery of P2X Inhibitors from Animal Venoms.
Sep 2019
Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00410

Bell, A., Brunt, J., Crost, E., Vaux, L., Nepravishta, R., Owen, D., Latousakis, D., Xiao, A., Li, W., Chen, X., Walsh, M. A., Claesen, J., Angulo, J., Thomas, G. H. & Juge, N.,
Elucidation of a novel sialic acid metabolism pathway in mucusforaging bacteria unravels mechanisms of adaptation to the gut.
Sep 2019, (Accepted/In press)
Nature Microbiology.

Ruiz, A., Alpízar, A., Beola, L., Rubio, C., Gavilán, H., Marciello, M., Rodriguez Ramiro, I., Ciordia, S., Morris, C. & del Puerto Morales, M.
Understanding the Influence of a Bifunctional Polyethylene Glycol Derivative in Protein Corona Formation around Iron Oxide Nanoparticles
Materials. 12, 14, 2218,10 Jul 2019
DOI: 10.3390/ma12142218

Saeed, A. & Dominguez Falcon, N.
Investigation into the effect of BMP-12 and TGF-1 on stimulation of tenogenic markers in serum-free cultured human adipose-derived stem cells (ADSCs).
June 2019

Bibic, L., Druskis, J., Walpole, S., Angulo Alvarez, J. & Stokes, L.
Bug Off Pain: An Educational Virtual Reality Game on Spider Venoms and Chronic Pain for Public Engagement
Journal of Chemical Education. May 2019
DOI: 10.1021/acs.jchemed.8b00905

Bibic, L
Spongy yet Sturdy: MOF Harvests water from air.
Journal of the American Chemical Society. 141, p. 4775. Mar 2019
DOI10.1021/jacs.9b02969

Pigliacelli, C., Belton, P., Wilde, P. & Qi, S
Probing the Molecular Interactions between Pharmaceutical Polymeric Carriers and Bile Salts in Simulated Gastrointestinal Fluids using NMR Spectroscopy.
Journal of Colloid, May 2019
DOI: 10.1016/j.jcis.2019.05.002

Falcon, N. D., Riley, G. & Saeed, A.
Induction of Tendon-Specific Markers in Adipose-Derived Stem Cells in Serum-Free Culture.
(Accepted/In press) Tissue Engineering. Part C, Methods. May 2019
DOI:10.1089/ten.TEC.2019.0080

Smith R, Weekes H, Morgan, L, Parkes M, Lee JC.
Tacrolimus suppositories: a safe and effective treatment for treatment-refractory proctitis (A-1951).
14th ECCO, Copenhagen, Denmark.  March 2019

Bidula, Stefan M., Cromer, Brett A., Walpole, Samuel., Angulo, Jesus, Stokes, Leanne.
Mapping a novel positive allosteric modulator binding site in the central vestibule region of human P2X7. (2019)
Scientific Reports volume 9, Article number: 3231

González-Paredes A, Sitia L, Ruyra A, Morris CJ, Wheeler GN, McArthur M, Gasco P.
Solid lipid nanoparticles for the delivery of anti-microbial oligonucleotides. (2019)
Eur J Pharm Biopharm. 134:166-177.
DOI: 10.1016/j.ejpb.2018.11.017. Epub 2018 Nov 20.

Dhuna, Kshitija., Felgate, Matthew., Bidula, Stefan M., Walpole, Samuel., Bibic, Lucka., Cromer, Brett A., Angulo, Jesus., Sanderson, Julie., Stebbing, Martin J and Stokes, Leanne.
Ginsenosides act as positive modulators of P2X4 receptors. 2018
Molecular Pharmacology, mol.118.113696;
DOI: 10.1124/mol.118.113696