The focus of our research is to understand the role of NF-E2 related factor 2 (NRF2) signalling in human leukaemia and myeloma.
NRF2 is a pivotal part of a cellular survival system. NRF2 functions to rapidly change the sensitivity of the intracellular environment to oxidants and electrophiles by stimulating the transcriptional activation of over a hundred cytoprotective and detoxification genes. Genes regulated by NRF2 have the capacity to prevent damage to DNA, proteins and lipids, and assist in the generation of new tissue. We have previously shown that human leukaemia cells use NRF2 to protect themselves from chemotherapy induced death.
The Association of International Cancer Research
Find out more by contacting Professor Kristian Bowles.