Examples of previous research Examples of previous research


Fast Indicate is the acronym for Clinical Efficacy of Functional Strength Training for upper limb motor recovery early after stoke: neural correlates and prognostic indicators.

Weakness of the arm and hand after stroke affects peoples' everyday lives and their capacity for independent living. Some treatments may be beneficial but this largely depends on a patient's ability to participate actively in repetitive practice of everyday (functional) tasks. Patients with substantial weakness may not be able to do this.


Functional Strength Training plus Conventional Physical Therapy (FST+CPT) enhances upper limb motor recovery early after stroke more than Movement Performance Therapy plus CPT (MPT+CPT).


To determine:

  • The relative efficacy of FST+CPT and MPT+CPT.

  • The neural correlates of improvement in response to FST+CPT and MPT+CPT.

  • Whether any one or combination of baseline measures predict improvement in motor function in response to FST+CPT or MPT+CPT.

  • Estimate cost-effectiveness to inform a subsequent definitive clinical trial.


VM Pomeroy, NS Ward, H Johansen-Berg, P van Vliet, JH Burridge, S Hunter, R Lemon, J Rothwell, CJ Weir, J Norrie, A Wing, GR Barton.

Clinical efficacy of functional strength training for upper limb motor recovery early after stroke: neural correlates and prognostic indicators. Efficacy and Mechanisms Evaluation Programme (The NIHR Evaluation, Trials and Studies Coordinating Centre (NETSCC), based at the University of Southampton, manages evaluation research programmes and activities for the NIHR).

3 years from January 2012, £1,231,854.00



  • A Falls prediction and prevention programme in older Adults with Rheumatoid Arthritis (RA)  (FALLS)

  • Funding: NIHR's Research for Patient Benefit (RfPB) programme

  • Key Contact: Dr Celia Clarke

  • RA is the most common form of Arthritis in the UK.  The aim of this study is to obtain knowledge of the factors which make falls in older adults with RA more likely and to provide detailed guidance on falling prevention in patients with RA.


SWIFT Cast Trial

  • Clinical efficacy of the Soft-Scotch Walking Initial FooT Cast  (SWIFT Cast) on walking recovery early after stroke and the neural-biomechanical correlates of response.

  • Funding: The Efficacy and Mechanism Evaluation Program (MRC-funded, NIHR-managed).

  • Key Contact: Andrew Walker

  • Weakness of the leg and foot is common after stroke. This affects peoples' everyday lives. For example, being unable to cross the road in the time allowed at most Pelican crossings.


  • Supported Communication to Improve Participation in Rehabilitation of people with moderate-severe aphasia after stroke (SCIP-R)

  • Funding: NIHR's Research for Patient Benefit (RfPB) programme

  • Key Contact: Simon Horton

  • About a third of people who have a stroke for the first time experience aphasia, a communication disorder affecting speaking, understanding, writing or reading. Aphasia is associated with longer stays in hospital and has severe consequences for all aspects of life. People with aphasia may not fully benefit from stroke rehabilitation for a number of reasons to do with their communication.

  • Here's a link to a video made about some of the findings from this study. Making the video was an opportunity to further involve people with aphasia as collaborators (PPI) as well as disseminating the findings to a lay and professional audience.


  • Funding: The Stroke Association

  • Key Contact: Kath Mares

  • Every day we need to perform a wide range of movements, such as walking, lifting, pushing, pulling, bending and twisting. The purpose of Functional Strength Training (FST) is to work to improve strength in a way that the activities of daily living are easier to perform.

  • This means practising tasks while gradually increasing the number of repetitions or making it harder bit by bit. FST is a progressive, resistive, low-intensity exercise.


  • Funding: PhD Project

  • Key Contact: Nicola Hancock

  • Objective and sensitive measurement of motor impairment after stroke in clinical settings is challenging. Clinical measures, e.g the Motricity Index (MI), do not provide i) biological insights into recovery or ii) information about movement performance during functional activities. Motion analysis systems are expensive and often inaccessible in clinical practice. This study is investigating test-retest reliability and concurrent validity of instrumented upright Pedalling (UP) on an exercise bike as a potential objective sensitive clinical measure of motor impairment.