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Modelling heart development and disease
The Smith Lab uses pluripotent stem cell-derived cardiomyocytes to model heart development and disease (including hypertrophic and dilated cardiomyopathy). Research has focused on how signalling can be modulated through extracellular matrix molecules (such as proteoglycans and glycosaminoglycans) and non-coding RNAs (such as snoRNAs).
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Group Leader: Dr James Smith
View my research profileI started working at UEA in 2019 as an Associate Professor in Stem Cell Biology, working with pluripotent stem cells as a group leader within the Metabolic Health Research Centre.
Please get in touch regarding PhD research opportunities
Select group publications
Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes
Johnson BB, Cosson MV, Tsansizi LI, Holmes TL, Gilmore T, Hampton K, Song OR, Vo NTN, Nasir A, Chabronova A, Denning C, Peffers MJ, Merry CLR, Whitelock J, Troeberg L, Rushworth SA, Bernardo AS, Smith JGW. Cell Rep. 2024;43(1):113668.
Johnson BB, Reinhold J, Holmes TL, Moore JA, Cowell V, Bernardo AS, Rushworth SA, Vassiliou V, Smith JGW. Metabolites. 2021;12(1).
James V, Nizamudeen ZA, Lea D, Dottorini T, Holmes TL, Johnson BB, Arkill KP, Denning C, Smith JGW. Stem Cells Dev. 2021;30(24):1215-27.
Smith JGW, Owen T, Bhagwan JR, Mosqueira D, Scott E, Mannhardt I, Patel A, Barriales-Villa R, Monserrat L, Hansen A, Eschenhagen T, Harding SE, Marston S, Denning C. Stem Cell Reports. 2018;11(5):1226-43.
Celiz AD, Smith JGW, Patel AK, Hook AL, Rajamohan D, George VT, Flatt L, Patel MJ, Epa VC, Singh T, Langer R, Anderson DG, Allen ND, Hay DC, Winkler DA, Barrett DA, Davies MC, Young LE, Denning C, Alexander MR. Adv Mater. 2015;27(27):4006-12.