BRoccoli In Osteoarthritis
The first study of knee pain and broccoli intervention in humans
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A dietary intervention trial to examine the protective effect of broccoli bioactives (specifically sulforaphane) on osteoarthritis
The BRIO study
Osteoarthritis is the most common form of joint disease and affects at least 8 million people in the United Kingdom. This pilot study is a multi-centre, randomised, placebo-controlled, double-blind dietary intervention designed to look at whether broccoli can affect pain in patients with knee osteoarthritis. This means that participants will be randomly assigned to consume the control soup or broccoli soup. Nobody will know which group the participants are assigned until after the trial has finished. This pilot study is crucial for the design and implementation of a full-scale trial that may benefit millions of people.
How will this help?
Osteoarthritis and pain
Pilot study
RCT Design
Dietary intervention
Norwich and Leeds study sites
Broccoli soup
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We're here
Postal Adress: BRIO Research Team, Biomedical Research Centre, University of East Anglia, Norwich Research Park, Norwich, Norfolk, NR4 7TJ, United Kingdom
Phone: +44(0) 1603 591471
Email: brio.study@uea.ac.uk
Our publications
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Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo
Read moreAugust 2013
by Davidson and Jupp et al.-
This study examines the impact of sulforaphane treatment on signalling pathways in human articular chondrocytes from the knee and demonstrates that sulforaphane might prevent cartilage destruction in osteoarthritis.
The potential for dietary factors to prevent or treat osteoarthritis
Read moreMay 2014
by Green et al.
Dietary modification could be effective in preventing osteoarthritis. This review focuses on dietary factors that may reduce the risk or progression of QA, including micronutrients, fatty acids, flavonoids and phytochemicals.
Dietary intervention for osteoarthritis: Clinical trials after the ‘Bone and Joint Decade’
Read moreAugust 2015
by Davidson and Clark
There is an unmet need for investment in clinical trials of dietary intervention, for developing disease biomarkers and refining the definition of OA so that. clinically relevant outcome measures can be improved.
Isothiocyanates are detected in human synovial fluid following broccoli consumption and can affect the tissues of the knee joint
Read moreJune 2017
by Davidson et al.
The detection of broccoli-derived natural compounds in the human knee joint following consumption of steamed broccoli and how these may change the protein profile of synovial fluid.
Impact and therapy of osteoarthritis: the Arthritis Care OA Nation 2012 survey
Read moreSeptember 2015
by Conaghan et al.
This study explored the personal impact of osteoarthritis in a sample of 2000 people in the UK: most reported persistent pain despite medication; the economic and social impact was large; and a need for improvement was identified in the provision of information and promotion of self-management strategies by clinicians to support people in managing their condition.
Pain reduction with oral methotrexate in knee osteoarthritis, a pragmatic phase iii trial of treatment effectiveness (PROMOTE): study protocol for a randomized controlled trial
Read moreThis paper outlines the study protocol for the PROMOTE trial which. aims to understand whether methotrexate, the most commonly used drug for treating rheumatoid arthritis, is effective at reducing pain and symptoms of osteoarthritis. The study. has recently completed and results will be published shortly.
Hydroxychloroquine Effectiveness in Reducing Symptoms of Hand Osteoarthritis: A Randomized Trial
Read moreThis large UK trial found that hydroxychloroquine was not more effective that placebo in reducing symptoms in people with moderate to severe hand osteoarthritis, providing evidence for a change in practice for the off-label use of this drug in these patients.
Meet the Researchers
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Prof Alex MacGregor
Chief Investigator
Chair of Chronic Diseases and Genetic Epidemiology (UEA)
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Prof Ian Clark
Co-Investigator
Chair of Musculoskeletal Biology (UEA)
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Prof Philip Conaghan
Co-Investigator
Chair of Musculoskeletal Medicine (Leeds)
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Dr Sarah Kingsbury
Co-Investigator
Osteoarthritis Strategic Lead (Leeds)
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Prof Aedin Cassidy
Co-Investigator
Professor of Nutrition (UEA)
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Dr Allan Clark
Co-Investigator, Biostatistician
Senior Lecturer in Medical Statistics (UEA)
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Prof William Fraser
Co-Investigator
Chair of Medicine (UEA)
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Dr Rose Davidson
Trial Manager
Research Scientist (UEA)
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Mrs Laura Watts
Senior Research Associate (UEA)
Link to related sites
These sites provide information on BRIO and other arthritis related clinical and research based studies.