Advanced methods for characterisation and delivery Advanced methods for characterisation and delivery

We are applying powerful analytical and modelling techniques to understand the properties of pharmaceuticals and design new methods for drug delivery. Novel advanced materials, soft matter and gel-based delivery systems are all under investigation using solution and solid-state NMR, thermal methods, atomic force microscopy, X-ray crystallography and computational modelling.

The section is active in the development of new nanopharmaceuticals, materials for pulmonary delivery (including peptides), polymer based pharmaceutical dispersions and the synthesis of polymeric biomaterials for application in tissue engineering and regenerative medicine.

Staff

Dr Jesús Angulo

  • Structural Glycobiology: Molecular basis of biologically relevant Protein-Carbohydrate interactions
  • Development of novel STD NMR methods: ligand screening, affinity, and pharmacophore determination
  • Synergistic combination of NMR spectroscopy and Molecular Dynamics: NMR-guided 3D molecular models of protein-ligand complexes
  • Carbohydrate-based soft matter (hydrogels): structure, dynamics, role of water and correlation to macroscopic properties

Dr László Fábián

  • Design of multi-component solids, understanding and control of transformations between solid forms of drugs
  • Structural informatics: using structural information to explain and design materials properties
  • Structural and physichochemical characterisation of pharmaceutical materials
  • Molecular modelling of materials: molecular dynamics and ab-initio methods

Prof Yaroslav Khimyak

  • NMR elucidation of structure and dynamics of materials with limited long-range ordering and soft solids
  • Polymer based and amorphous pharmaceutical systems for drug delivery: understanding of intermolecular interactions
  • Design and application of porous solids for drug delivery

Dr Chris Morris

  • Antimicrobial peptide and nanomaterial disposition in the airways
  • Development of polymer-peptide platforms for delivery of biologically active peptide drugs to the mucosal barriers of the gut and the lung
  • Development of cellular and non-cellular model systems for studying macromolecule interactions with mucosal barriers

Dr Sheng Qi

  • Delivery of poorly water-soluble drugs, including using lipid-based formulations and hot melt extruded solid dispersions
  • Physicochemical characterisation of pharmaceutical materials and dosage forms
  • Amorphous pharmaceuticals

Dr Andrew Round

  • Developing Sliding Rotaxane Force Spectroscopy for single molecule glycan sequence mapping
  • Using AFM to study heterogeneity and complexity in biological macromolecules including pectin and mucin
  • Studying drug-macromolecule interactions at the single molecule level

Dr Aram Saeed

  • Acellular 3D biomaterial matrices for use in cellular expansion (In vitro use)
  • Injectable hydrogels as cellular and therapeutic proteins delivery system (In vivo cellular based therapy)
  • 3D printing of complex cellular organisation and tissue-like pattern
  • Design, synthesis and characterisation of polymeric nanoparticulate drug delivery system
  • Targeted therapeutics for cancer treatment with “Smart” nanomaterial with controlled-release features