The latest research publications and papers from within the school of Pharmacy.

Bacterial mechanisms of reversible protein S-thiolation: Structural and mechanistic insights into mycoredoxins
H. Antelmann.* C.J. Hamilton,* Mol. Microbiol. 2012, 86, 759-764.
DOI: 10.1111/mmi.12031

Low molecular weight thiols in thiol-disulfide exchange
K.V. Laer, C. Hamilton,*  J. Messens.* 
Antiox Redox Signal 2012 (in press).
DOI:10.1089/ars.2012.4964.

S-bacillithiolation protects conserved and essential proteins against hypochlorite stress in Firmicutes bacteria
B.K. Chi, A.A. Roberts, T.T.T. Huyen, K. Gronau, D. Becher, D. Albrecht, C.J. Hamilton, H. Antelmann.*  Antiox Redox Signal 2012 (in press).
DOI:10.1089/ars.2012.4686.

Conformational Changes Undergone by Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase Upon Substrate Binding: The Role of N-lobe and Enantiomeric Substrate Preference
J. Ignacio, J. S-Aparicio, H. Whitfield, C. Hamilton, C. Brearly,* B. Gonzalez.*
J. Biol. Chem. 2012 287, 29237-29249
DOI: 10.1074/jbc.M112.363671

Jak2 and Stat3 activation is not essential for CCL3, CCL5 or CCL8 induced chemotaxis
Khabbazi S, Jacques RO, Moyano Cardaba C, Mueller A
Cell Biochemistry and Function, accepted manuscript, 2012

Cellular uptake studies of two hexanuclear, carboxylate bridged, zinc ring structures using fluorescence microscopy
Redshaw C, Elsegood MR, Frese JW, Ashby S, Chao Y, Mueller A.
Chem Commun (Camb). 2012 Jul 7;48(53):6627-9. Epub 2012 May 1
DOI: 10.1039/C2CC32060F

Transferrin Coated Nanoparticles: Study of the Bionano Interface in Human Plasma
Pitek AS, O'Connell D, Mahon E, Monopoli MP, Baldelli Bombelli F, et al.
PLoS ONE 2012 7(7): e40685.
DOI:10.1371/journal.pone.0040685

Antitumor activity of a duocarmycin analogue rationalised to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder.
Sutherland M, Gill JH, Loadman PM, Laye JP, Sheldrake HM, Illingworth NA, Alandas MN, Cooper PA, Searcey M, Pors K, Shnyder SD, Patterson LH.
Mol Cancer Ther. 2012 Oct 1.

A model for a solvent-free synthetic organic research laboratory: click-mechanosynthesis and structural characterization of thioureas without bulk solvents
Vjekoslav Štrukil, Marina D. Igrc, László Fábián, Mirjana Eckert-Maksić, Scott L. Childs, David G. Reid, Melinda J. Duer, Ivan Halasz, Cristina Mottillo and Tomislav Friščić
Green Chem., 2012,14, 2462-2473
DOI: 10.1039/C2GC35799B
 
The Development of Thermal Nanoprobe Methods as a Means of Characterizing and Mapping Plasticizer Incorporation into Ethylcellulose Films
Meng J, Levina M, Rajabi-Siahboomi AR, Round AN, Reading M, Craig DQM
Pharm. Res. 2012, 29, (8), 2128-2138
DOI: 10.1007/s11095-012-0742-4

The Development of Modulated, Quasi-Isothermal and Ultraslow Thermal Methods as a Means of Characterizing the α to γ Indomethacin Polymorphic Transformation.
Qi S, Craig DQ.
Mol. Pharmaceutics, 2012, 9 (5), pp 1087–1099
DOI: 10.1021/mp2003412

Synthesis of Small Molecules Targeting Multiple DNA Structures using Click Chemistry.
Howell LA, Bowater RA, O'Connell MA, Reszka AP, Neidle S, Searcey M.
ChemMedChem. 2012, 7, (5), 792–804
DOI: 10.1002/cmdc.201200060.

A cost-consequences analysis of an adherence focused pharmacist-led medication review service.
Desborough JA, Sach T, Bhattacharya D, Holland RC, Wright DJ.
Int J Pharm Pract. 2012 Feb;20(1):41-9.
DOI: 10.1111/j.2042-7174.2011.00161.x

CCL3 induced migration occurs independently of intracellular calcium release.
Moyano Cardaba C, Jacques RO, Barrett JE, Hassell KM, Kavanagh A, Remington FC, Tse T, Mueller A.
Biochem Biophys Res Commun. 2012 Feb 3;418(1):17-21
DOI:10.1016/j.bbrc.2011.12.081

Understanding the role of miRNA in regulating NF-κB in blood cancer.
Rushworth SA, Murray MY, Barrera LN, Heasman SA, Zaitseva L, Macewan DJ.
Am J Cancer Res. 2012;2(1):65-74

An investigation into water interactions with amorphous and milled salbutamol sulphate: the development of predictive models for uptake and recrystallization.
Grisedale LC, Belton PS, Jamieson MJ, Barker SA, Craig DQ.
Int J Pharm. 2012 Jan 17;422(1-2):220-8.
DOI: 10.1016/j.ijpharm.2011.10.055

Micro RNAs as a new therapeutic target towards leukaemia signalling.
Murray MY, Rushworth SA, MacEwan DJ.
Cell Signal. 2012 Feb;24(2):363-8
DOI:0.1016/j.cellsig.2011.09.021

The Cambridge Structural Database System and Its Applications in Supramolecular Chemistry and Materials Design, in Supramolecular Chemistry: From Molecules to Nanomaterials
E. Pidcock, J.A. Chisholm, P.A. Wood, P.T.A. Galek, L. Fabian, O. Korb, A.J. Cruz-Cabeza, J.W. Liebeschuetz, C.R. Groom, F.H. Allen: , Edited by Philip A. Gale and Jonathan W. Steed, 2012,
John Wiley & Sons, Ltd. ISBN: 978-0-470-74640-0

Pegylation of antimicrobial peptide maintains the active peptide conformation, model membrane interactions and antimicrobial activity while improving lung tissue biocompatibility following airway delivery.
Antimicrob. Agents Chemother. (2012) In Press
DOI:10.1128/AAC.06335-11

Vitamin D: Potential in the prevention and treatment of lung cancer.
Norton R and O'Connell MA. 
Anticancer Research, 2012, 32, 211-222.

An exploratory study of primary care pharmacist-led epilepsy consultations
Fogg A, Staufenberg EF, Small I, Bhattacharya D
International Journal of Pharmacy Practice, 2012; 20(5):294-302.
DOI: 10.1111/j.2042-7174.2012.00207.x.

A cost-consequences analysis of an adherence focused pharmacist-led medication review service.
Desborough, J. A., Sach, T., Bhattacharya, D, Holland, R. C. and Wright, D. J.International Journal of Pharmacy Practice, 2012, 20: 41–49.
DOI: 10.1111/j.2042-7174.2011.00161.x

Capecitabine non-adherence: exploration of magnitude, nature and contributing factor.
Easthall, C, Willoughby, K, Small, M, Watson, S, Bhattacharya, D.
Journal of Oncology Pharmacy Practice. 2012.
DOI: 10.1177/1078155211436022