Publications and Papers

The latest research publications and papers from within the school of Pharmacy.

The Role of the Mucus Barrier in Digestion
Mackie, AR, Round, A, Rigby, NM and Macierzanka, A
Food Digestion, 2012, 3, 1-3, 8-15
DOI: 10.1007/s13228-012-0021-1

Lamellar Structures of MUC2-Rich Mucin: A Potential Role in Governing the Barrier and Lubricating Functions of Intestinal Mucus
Round, AN, Rigby, NM, Garcia de la Torre, A, Macierzanka, A, Mills, ENC and Mackie, AR
Biomacromolecules, 2012 13 (10). pp. 3253-3261. ISSN 1526-4602
DOI: 10.1021/bm301024x

Mechanistic studies of FosB: a divalent metal-dependent bacillithiol-S-transferase that mediates fosfomycin resistance in Staphylococcus aureus
A.A. Roberts, S.V. Sharma, A.W. Strankman, S.R. Duran, M. Rawat, C.J. Hamilton*
  Biochem. J. 2013, 451, 69-79
  DOI: 10.1042/BJ20121541

Distribution and infection related functions of bacillithiol in Staphylococcus aureus
D. Pöther, P. Gierok, M. Harms3, J. Mostertz, F. Hochgräfe, H. Antelmann, C.J. Hamilton, I. Borovok, M. Lalk, Y. Aharonowitz, M. Hecker*
  Int. J. Med. Microbiol. 2012 (in press)
  DOI: 10.1016/j.ijmm.2013.01.003

Low molecular weight thiols in thiol-disulfide exchange
K.V. Laer, C. Hamilton,^* J. Messens.^*
Antiox Redox Signal 2012 (in press).
DOI:10.1089/ars.2012.4964.

S-bacillithiolation protects conserved and essential proteins against hypochlorite stress in Firmicutes bacteria
B.K. Chi, A.A. Roberts, T.T.T. Huyen, K. Gronau, D. Becher, D. Albrecht, C.J. Hamilton, H. Antelmann.* Antiox Redox Signal 2012 (in press).
  DOI:10.1089/ars.2012.4686.

Conformational Changes Undergone by Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase Upon Substrate Binding: The Role of N-lobe and Enantiomeric Substrate Preference
  J. Ignacio, J. S-Aparicio, H. Whitfield, C. Hamilton, C. Brearly,* B. Gonzalez.*
  J. Biol. Chem. 2012 287, 29237-29249
  DOI: 10.1074/jbc.M112.363671

  Jak2 and Stat3 activation is not essential for CCL3, CCL5 or CCL8 induced chemotaxis
  Khabbazi S, Jacques RO, Moyano Cardaba C, Mueller A
Cell Biochemistry and Function, accepted manuscript, 2012

Cellular uptake studies of two hexanuclear, carboxylate bridged, zinc ring structures using fluorescence microscopy
  Redshaw C, Elsegood MR, Frese JW, Ashby S, Chao Y, Mueller A.
  Chem Commun (Camb). 2012 Jul 7;48(53):6627-9. Epub 2012 May 1
  DOI: 10.1039/C2CC32060F

Transferrin Coated Nanoparticles: Study of the Bionano Interface in Human Plasma
  Pitek AS, O'Connell D, Mahon E, Monopoli MP, Baldelli Bombelli F, et al.
  PLoS ONE 2012 7(7): e40685.
  DOI:10.1371/journal.pone.0040685

Antitumor activity of a duocarmycin analogue rationalised to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder.
  Sutherland M, Gill JH, Loadman PM, Laye JP, Sheldrake HM, Illingworth NA, Alandas MN, Cooper PA, Searcey M, Pors K, Shnyder SD, Patterson LH.
  Mol Cancer Ther. 2012 Oct 1.

A model for a solvent-free synthetic organic research laboratory: click-mechanosynthesis and structural characterization of thioureas without bulk solvents
  Vjekoslav Štrukil, Marina D. Igrc, László Fábián, Mirjana Eckert-Maksić, Scott L. Childs, David G. Reid, Melinda J. Duer, Ivan Halasz, Cristina Mottillo and Tomislav Friščić
Green Chem., 2012,14, 2462-2473
  DOI: 10.1039/C2GC35799B

The Development of Thermal Nanoprobe Methods as a Means of Characterizing and Mapping Plasticizer Incorporation into Ethylcellulose Films
  Meng J, Levina M, Rajabi-Siahboomi AR, Round AN, Reading M, Craig DQM
  Pharm. Res. 2012, 29, (8), 2128-2138
  DOI: 10.1007/s11095-012-0742-4

The Development of Modulated, Quasi-Isothermal and Ultraslow Thermal Methods as a Means of Characterizing the α to γ Indomethacin Polymorphic Transformation.
  Qi S, Craig DQ.
  Mol. Pharmaceutics, 2012, 9 (5), pp 1087–1099
  DOI: 10.1021/mp2003412

Synthesis of Small Molecules Targeting Multiple DNA Structures using Click Chemistry.
Howell LA, Bowater RA, O'Connell MA, Reszka AP, Neidle S, Searcey M.
  ChemMedChem. 2012, 7, (5), 792–804
  DOI: 10.1002/cmdc.201200060.

A cost-consequences analysis of an adherence focused pharmacist-led medication review service.
  Desborough JA, Sach T, Bhattacharya D, Holland RC, Wright DJ.
  Int J Pharm Pract. 2012 Feb;20(1):41-9.
  DOI: 10.1111/j.2042-7174.2011.00161.x

CCL3 induced migration occurs independently of intracellular calcium release.
  Moyano Cardaba C, Jacques RO, Barrett JE, Hassell KM, Kavanagh A, Remington FC, Tse T, Mueller A.
  Biochem Biophys Res Commun. 2012 Feb 3;418(1):17-21
  DOI:10.1016/j.bbrc.2011.12.081

Understanding the role of miRNA in regulating NF-κB in blood cancer.
Rushworth SA, Murray MY, Barrera LN, Heasman SA, Zaitseva L, Macewan DJ.
Am J Cancer Res. 2012;2(1):65-74

Micro RNAs as a new therapeutic target towards leukaemia signalling.
Murray MY, Rushworth SA, MacEwan DJ.
Cell Signal. 2012 Feb;24(2):363-8
DOI:0.1016/j.cellsig.2011.09.021

The Cambridge Structural Database System and Its Applications in Supramolecular Chemistry and Materials Design, in Supramolecular Chemistry: From Molecules to Nanomaterials
E. Pidcock, J.A. Chisholm, P.A. Wood, P.T.A. Galek, L. Fabian, O. Korb, A.J. Cruz-Cabeza, J.W. Liebeschuetz, C.R. Groom, F.H. Allen: , Edited by Philip A. Gale and Jonathan W. Steed, 2012,
John Wiley & Sons, Ltd. ISBN: 978-0-470-74640-0

Pegylation of antimicrobial peptide maintains the active peptide conformation, model membrane interactions and antimicrobial activity while improving lung tissue biocompatibility following airway delivery.
Antimicrob. Agents Chemother. (2012) In Press
DOI:10.1128/AAC.06335-11