Healthy ageing Healthy ageing

Within the School of Pharmacy, we believe that healthy ageing is shaped by genetic and environmental factors throughout an individual’s life from the point of conception onwards. We embrace an integrated and cross-disciplinary approach towards healthy ageing and our research spans from the identification and validation of new targets, nutrition, medicinal chemistry and drug discovery through to innovative formulations and improvements in patient welfare. Through our multidisciplinary research, we have extensive collaborations with industrial and academic collaborators across the Norwich Research Park, the UK and the world.

Key areas of research within Healthy Ageing are:

  • Cancer
  • Neurodegenerative diseases
  • Inflammation
  • Infectious diseases
  • Protein-protein and protein-nucleic acid interactions
  • Biologically active natural products
  • Epigenetics
  • Patient adherence and medicines management 

This theme is led by Prof Ganesan.

Dr Wafa Al-Jamal

Dr Wafa Al-Jamal

  • Nanomedicines for prostate cancer
  • Development of smart viral and non-viral vectors for gene therapy
  • Evaluation of therapeutic efficacy and safety of nanomedicines

Dr Jesús Angulo

Dr Jesus Angulo

  • Carbohydrate-protein interactions in infection processes
  • Biological NMR spectroscopy for receptor-ligand interactions in health and disease

Dr Debi Bhattacharya

Dr Debi Bhattacharya

  • Intentional and unintentional medication non-adherence including the use of administration aids
  • Development of the role of PCT and community pharmacists
  • Development of interventions informed by theoretical behaviour models

Dr James Desborough

Dr James Desborough

  • Medication review in older people
  • Medicines management health services research focused on older people

Prof Ganesan

Prof Ganesan

  • Organic synthesis of biologically active natural products
  • Synthesis of epigenetic enzyme inhibitors for cancer and infectious diseases
  • Synthesis of therapeutically relevant protease inhibitors, calcium signalling probes and antibiotics

Dr Chris Hamilton

Dr Chris Hamilton

 

  • Chemical and biochemical functions of low molecular weight thiols in Gram positive bacteria.
  • Redox mechanisms of bioactive organosulfur metabolites from garlic
  • Mechanistic enzymology

Dr Chris Morris

  • Phage display identification and validation of cancer biomarkers
  • Experimental peptide therapeutics for skin cancer and lung infection
  • Triggered delivery systems for antibiotic delivery through lung mucus and biofilms

Dr Anja Mueller

Dr Anja Mueller

  • Metastasis and chemokine receptors
  • Novel therapeutics for cancer treatment
  • Investigating the activation patterns of chemokine receptors on inflammatory diseases

Dr Maria O'Connell

Dr Anja Mueller

  • Age-related disease and cellular antioxidants
  • Resolution of Inflammation – new targets and mechanisms of action
  • Dietary, plant and marine bioactives – mechanisms of action in inflammation and chronic disease
  • Novel therapeutics for cancer

Dr Sheng Qi

  • Design and development of age-adapted drug formulations
  • Novel delivery systems for nutriceuticals
  • Taste masking technologies
  • Combination therapy: formulation design and manufacturing

Dr Aram Saeed

Dr Aram Saeed

  • Acellular 3D biomaterial matrices for use in cellular expansion (In vitro use)
  • Injectable hydrogels as cellular and therapeutic proteins delivery system (In vivo cellular based therapy)
  • 3D printing of complex cellular organisation and tissue-like patterns in chronic disease
  • Targeted therapeutics for cancer treatment with “Smart” nanomaterial with controlled-release features

Dr Julie Sanderson

Dr Julie Sanderson

  • Mechanisms underlying retinal ganglion cell neurodegeneration in glaucoma
  • Involvement of purinergic signalling in ocular disease
  • Development of ex vivo human tissue models for study of ocular disease and toxicology

Prof Mark Searcey

Prof Mark Searcey

  • Inhibition of protein-DNA and protein-protein interactions
  • Targeting nucleic acids and DNA repair and proliferation
  • Solution and solid phase natural product synthesis from synthetic sources

Dr Leanne Stokes

Dr Leanne Stokes

 

  • Purinergic receptor signaling pathways in immune cells
  • Pharmacology of purinergic ion channels
  • Inflammatory signalling in glial cells

Dr Michael Twigg

Dr Michael Twigg

  • Development of the role of the community pharmacist in managing and supporting patients with long term conditions
  • Development and evaluation of pharmacist consultation skills
  • Qualitative research on patients' and healthcare professionals' perception of the role of the pharmacist in primary care

Dr Zoë Waller

Dr Zoë Waller

  • Studying the effects of cations and natural ligands on DNA/RNA structure and function
  • Investigating the effects of alternative nucleic acid secondary structures in the development of genetic diseases
  • Development of new ligands and potential drugs to target cancer, diabetes and degenerative diseases

Prof David Wright

Prof David Wright

  • Development of the role of the pharmacist in both primary and secondary care
  • Care of older people and optimisation of drug therapy, particularly in those patients with swallowing difficulties
  • Medicines management in care homes