multidisciplinary dementia research multidisciplinary dementia research

The demenTia Research And Care Clinic (TRACC) aims to become a centre of excellence in the field of dementia research. An expert multidisciplinary team, working in close contact with local NHS staff, will follow participants longitudinally from diagnosis (or even pre-diagnosis) to the end stages of dementia. This transdiagnostic study involves neurodegenerative conditions, such as Alzheimer’s disease and frontotemporal dementia, which have varying structural changes in the brain but overlapping cognitive and behavioural changes. A comprehensive assessment package, including neuropsychological measures, collection of blood, urine and stool samples, and brain imaging, will generate data to inform key research questions, while providing research participants and their care professionals with clinical feedback. The newly gained knowledge from this study will lead to improved diagnostic accuracy, even in the early stages, which will increase the efficacy of new disease modifying therapies.

key research questions key research questions

1. To longitudinally track the disease progression in patient participants across various neurodegenerative conditions and profile cognitive, functional, and behavioural changes.

2. To track carers’ coping and wellbeing directly related to their role as a carer over the same time period, and the relationship between these factors and changes in the participant.

3. To relate cognitive and behavioural changes to alterations in brain structure and function, as well as peripheral blood, genetic, and nutritional biomarkers.

4. To develop novel assessment tools to improve differentiation between neurodegenerative diagnoses and measurement of behavioural, cognitive, and functional aspects of disease progression.

5. To develop improved measures designed to better reflect the experience of carers which will direct novel carer interventions to support both people with neurodegeneration and their carers.


research design and outputs research design and outputs

Participants are invited to a home screening visit, where a basic dementia work-up is administered. Participants may then be invited to a TRACC appointment, at our research clinic based in Hammerton Court, Norfolk and Suffolk Foundation Trust (NSFT). Neuropsychological testing, clinical interviews, blood, stool, urine samples, and neuroimaging may be collected.

Families may then be invited to return to the TRACC clinic following 12 months, where all assessments are repeated.

the research team the research team

Chief Investigator: Professor Michael Hornberger (UEA)

Professor Eneida Mioshi
Emma Flanagan
Dr Stephen Jeffs

Norfolk and Suffolk Foundation Trust (NSFT)
Kim Clipsham
Claire Rischmiller
Zoe Inman
Michelle Hagon-Powley
Louise McCarthy
Dr Bonnie Teague

Norfolk and Norwich University Hospital (NNUH)
Dr David Dick
Dr Muhammad Rafiq