Number of depressed over 65s unchanged but antidepressant use soars

Published by  News Archive

On 7th Oct 2019

The proportion of people aged over 65 on antidepressants has more than doubled in two decades – according to new research led by the University of East Anglia.

Despite a rise in antidepressant use, there was little change in the number of older people diagnosed with depression.

The findings are based on the Cognitive Function and Ageing Studies, conducted at two time points - between 1991 and 1993, and between 2008 and 2011. 

Researchers interviewed more than 15,000 over 65s in England and Wales to see whether the prevalence of depression and antidepressant use is changing.

Lead author Prof Antony Arthur, from UEA’s School of Health Sciences, said: “Depression is a leading cause of poor quality of life worldwide and we know that older people may be less likely than other age groups to go to their GP with symptoms of depression. 

“Until now, little was known about how the relationship between the prevalence of depression and antidepressant use among older people has changed over time. The Cognitive Function and Ageing Studies led by the University of Cambridge have the ability to exam changes in the health needs of older people across generations based on random sampling and diagnostic methods held constant over time.

“We asked participants about their health, daily activities, use of health and social care services, and the medications they were taking.

“We used a standardised interview process to ascertain the presence or absence of symptoms of depression and then applied diagnostic criteria to see whether the participant was considered to have ‘case level’ depression, a level of depression more severe than that characterised by minor mood symptoms, such as loss of energy, interest or enjoyment.”

The study’s lead investigator Prof Carol Brayne, director of the Cambridge Institute of Public Health, said: "Our research has previously shown a dramatic age-for-age drop in dementia occurrence across generations. This new work reveals that depression has not shown the same reduction even in the presence of dramatically increased prescribing, itself not without concern given potential adverse effects we have also shown that are associated with polypharmacy."

Key findings

  • The proportion of older people receiving anti-depressant medication more than doubled over two decades – from 4.2 per cent in the early nineties to 10.7 per cent 20 years later.

  • The estimated prevalence of depression among over 65s in the early 1990s was 7.9 per cent, compared to 6.8 per cent 20 years later.

  • Depression and antidepressant use was more common in women than men at both time points. 

  • Depression was associated with living in a more deprived area.

  • The proportion of over 65s living in care homes declined, but prevalence of depression in care homes remained unchanged – affecting around one in ten residents.

  • Across both time periods, most people with case-level depression were not on antidepressants, while most of those on antidepressants did not have depression.

Prof Arthur said: “Depression affects one in 15 people aged over 65, and its impact is felt by the individual, their families and friends.

“Between two comparable samples interviewed 20 years apart (1990-93 and 2008-11) we found little change in the prevalence of depression, but the proportion of participants taking antidepressants rose from 4 per cent to almost 11 per cent. This could be due to improved recognition and treatment of depression, overprescribing, or use of antidepressants for other conditions.

“Whatever the explanation, substantial increases in prescribing has not reduced the prevalence of depression in the over-65 population. The causes of depression in older people, the factors that perpetuate it, and the best ways to manage it remain poorly understood and merit more attention.”

The research was led by the University of East Anglia in collaboration with the University of Cambridge, the University of Newcastle and the University of Nottingham.

‘Changing prevalence and treatment of depression among the over-65s over two decades: findings from the Cognitive Function and Ageing Studies’ is published in the British Journal of Psychiatry.

Latest News

  News
Businessman and businesswoman sitting face to face in a meeting
28 Sep 2020

Friendly interactions with Chinese people reduced Covid-19 prejudice

People with a history of positive social interactions with Chinese people were less likely to support discriminatory anti-Chinese policies as Covid-19 reached...

Read more >
  News
Vice Chancellor David Richardson with Covid-19 test box
28 Sep 2020

UEA launches asymptomatic Covid-19 testing for staff and students

The University of East Anglia (UEA) has today (28 September) launched in-house Covid-19 testing for its staff and students to help limit asymptomatic...

Read more >
  News
Wildfire at sunset
25 Sep 2020

New research strengthens evidence for climate change increasing risk of wildfires

A review of new scientific publications has found they strengthen the evidence that climate change increases the frequency and/or severity of fire weather in...

Read more >
Are you searching for something?
  News
Woman at her desk holding the nape of her neck
24 Sep 2020

Lockdown impact: worsening symptoms for people with bone, joint and muscle pain

People with bone, joint and muscle pain saw their symptoms worsen during lockdown – according to new research from the University of East Anglia.

Read more >
  News
Lorries queued on the M20 motorway in Kent
23 Sep 2020

No deal Brexit risks queues at the border and food shortages, new academic report finds

The most immediate and visible impact of the UK failing to get a deal with the EU will be seen at the border, with risks of queues and shortages of food, a new...

Read more >
  News
23 Sep 2020

Putting virtual rehab for stroke patients to the test

Researchers at the University of East Anglia have been putting virtual reality rehabilitation for stroke survivors to the test.

Read more >
  News
Reconstruction of the Roman Temple the Caistor team investigated
23 Sep 2020

East Anglian Studies uncovers region's rich history

Read more >
  News
Subtropical Atlantic Forest, Southern Brazil
15 Sep 2020

Study reveals impact of centuries of human activity in American tropics

The devastating effects of human activity on wildlife in the American tropics over the last 500 years are revealed in a new study published today.

Read more >
  News
Soldiers in a savannah
14 Sep 2020

Study examines how civil wars affect wildlife populations

A new study comprehensively reveals how civil wars impact wildlife in countries affected by conflict.

Read more >
  News
Union Jack and EU flag on cracked wall background

Amending Brexit deal will increase frictions within UK and beyond

The government’s decision to scrap part of its Brexit deal will increase frictions with the EU, as well as threatening the fragile political equilibrium in...

Read more >