Five types of bacteria linked to aggressive prostate cancer

Published by  News archive

On 20th Apr 2022

An empty urine test sample bottle.
Getty images

Researchers at the University of East Anglia have found a link between bacteria and aggressive forms of prostate cancer.


They identified five types of bacteria which were common in urine and tissue samples from men with aggressive prostate cancer.

It is hoped that these findings could help pave the way for treatments that could target these particular bacteria and slow or prevent the development of aggressive disease.

Project lead Prof Colin Cooper from UEA’s Norwich Medical School, said: “We already know of some strong associations between infections and cancer. For example, the presence of Helicobacter pylori bacteria in the digestive tract can lead to stomach ulcers and is associated with stomach cancer, and some types of the HPV virus can cause cervical cancer.

“We wanted to find out whether bacteria could be linked to the way prostate cancer grows and spreads.”

Dr Jeremy Clark, also from UEA’s Norwich Medical School, said: “While prostate cancer is responsible for a large proportion of all male cancer deaths, it is more commonly a disease men die with rather than from.

“And little is known about what causes some prostate cancers to become more aggressive than others. We now have evidence that certain bacteria are involved in this and are part of the puzzle.”

The team worked with colleagues at the Norfolk and Norwich University Hospital, the Quadram Institute, and other collaborators to analyse urine or tissue samples from more than 600 patients with or without prostate cancer. And they developed methods of finding the bacteria associated with aggressive prostate cancer.

Dr Rachel Hurst, first author of this work and also from UEA’s Norwich Medical School, said: “To detect the bacteria, we used many different approaches including whole genome sequencing of the tissue samples, a method which is being used increasingly as we transition into an era of genomic medicine.

“When tumour samples are sequenced, DNA from any pathogens present are also sequenced, making it possible to detect bacteria.

“We found several types of bacteria associated with aggressive prostate cancer, some of which are new types of bacteria never found before.”

Two of the new bacteria species found by the team have been named after two of the study’s funders - Porphyromonas bobii, after the The Bob Champion Cancer Trust and Varibaculum prostatecancerukia, after Prostate Cancer UK.

The set of bacteria found by the team include Anaerococcus, Peptoniphilus, Porphyromonas, Fenollaria and Fusobacterium. All of these are anaerobic, which means they like to grow without oxygen present.
Dr Hurst said: “When any of these specific anaerobic bacteria were detected in the patient’s samples, it was linked to the presence of higher grades of prostate cancer and more rapid progression to aggressive disease.

“We also identified potential biological mechanisms of how these bacteria may be linked to cancer.

“Among the things we don’t yet know is how people pick up these bacteria, whether they are causing the cancer, or whether a poor immune response permits the growth of the bacteria.

“But we hope that our findings and future work could lead to new treatment options, that could slow or prevent aggressive prostate cancer from developing. Our work could also lay the foundations for new tests that use bacteria to predict the most effective treatment for each man’s cancer,” she added.

The team also noted that many bacteria are beneficial to human life and it is not a simple matter to remove the harmful bacteria without removing the protection provided by the good bacteria.

Prof Daniel Brewer, from UEA’s Norwich Medical School and a visiting worker at the Earlham Institute, said: “Knowing when we can watch and wait or whether we need to start treatment is a major challenge for people with prostate cancer. If we can target aggressive cancers while sparing others from unnecessary treatment it will dramatically improve the way we manage this disease.

“There seems to be a clear link between these bacteria and the way the cancer is behaving. We need to understand this relationship in more detail but it’s a major step towards developing a cheap and quick test that could guide treatment decisions.”

Robert Mills, Urology Consultant at the Norfolk and Norwich University Hospital, said: “This research has shown a potential link between more aggressive prostate cancer and the presence of certain bacteria in the prostate and in urine. Whether this is cause or effect is not clear and will be the subject of further research.”

Collaborator Prof John Wain from the Quadram Institute said: “This research exemplifies the Norwich Research Park’s multidisciplinary approach to studying infection.
“The link between bacterial growth and cancer is not always straight forward and working with the cancer group at the Norwich Medical School has allowed us to demonstrate a possible link between bacteria living in the prostate and severe forms of prostate cancer.

“By combining advanced computational analysis of DNA sequence data from the urine of patients with an in depth understanding of cancer biology and the ability to characterise new species of bacteria we were able to show an association between the presence of several bacteria and progression to an aggressive form of prostate cancer. 

“This will now enable further work to determine if there are causal relationships between microbes and cancer.”

This research was led by the University of East Anglia in collaboration with the Quadram Institute and the Norfolk and Norwich University Hospital. Other collaborators included the Universities of Oxford, Cambridge, Manchester, St Andrews and Auckland, the Earlham Institute, the Institute of Cancer Research, the Royal Marsden NHS Foundation Trust, and Cancer Research UK.  

Dr Rachel Hurst, Dr Emma Meader, Dr Abraham Gihawi, and Dr Ghanasyam Rallapalli are the primary authors of this work and Prof Justin O’Grady, Prof Daniel Brewer, Prof John Wain, and Prof Colin Cooper co-led this project.

Dr Hayley Luxton, Research Impact Manager at Prostate Cancer UK, said: “This is an exciting discovery that has the potential to truly revolutionise treatment for men. 
 
“We currently have no way of reliably identifying aggressive prostate cancers, and this research could help make sure men get the right treatment for them. If the team can demonstrate that these newly-identified bacteria can not only predict, but actually cause aggressive prostate cancer, for the first time we may actually be able to prevent prostate cancer occurring. This would be a huge breakthrough that could save thousands of lives each year. 
 
“Sadly, one man still dies from prostate cancer every 45 minutes. That’s why we’re asking people to support Prostate Cancer UK as we continue to fund bold, innovative research like this that will stop prostate cancer limiting men’s lives.” 

It was funded by The Bob Champion Cancer Trust and Prostate Cancer UK.

‘Microbiomes of Urine and the Prostate are Linked to Human Prostate Cancer Risk Groups’ is published in the journal European Urology Oncology.

Latest News

 
A forest fire in the Amazon rainforest.
27 Jan 2023

Human activity has degraded more than a third of remaining Amazon rainforest

The Amazon rainforest has been degraded by a much greater extent than scientists previously believed, according to a new study.

Read more >
 
A child learning to write the alphabet.
27 Jan 2023

Poor literacy linked to worse mental health worldwide, study shows

Read more >
 
A Vitamin D tablet being held up to the sun.
26 Jan 2023

80-year-old medical mystery that caused baby deaths solved

Researchers at the University of East Anglia have solved an 80-year-old medical mystery that causes kidney damage in children and can be fatal in babies.

Read more >
 
A loudspeaker at a protest.
23 Jan 2023

There may be more power in the hand of the worker than previously thought

Employers who disproportionately punish striking workers may be acting unlawfully, according to new research from the University of East Anglia.

Read more >
Are you searching for something?
 
A loudspeaker at a protest.
23 Jan 2023

There may be more power in the hand of the worker than previously thought

Employers who disproportionately punish striking workers may be acting unlawfully, according to new research from the University of East Anglia.

Read more >
 
Two bottles of hormones held in a gloved hand.
14 Jan 2023

HRT could ward off Alzheimer’s among at-risk women

Hormone Replacement Therapy (HRT) could help prevent Alzheimer’s Dementia among women at risk of developing the disease – according to University of East Anglia...

Read more >
 
A thermometer against a blue sky with blazing sun
12 Jan 2023

2022 sixth warmest year on record for global temperature

Globally 2022 was the sixth warmest year in a series stretching back to 1850, according to figures released today by the Met Office and University of East Anglia.

Read more >
 
Photo of Heidi Crisp
01 Jan 2023

HSC apprentice shortlisted for finalist in prestigious awards

Occupational therapist apprentice, Heidi Crisp has been shortlisted as one of three finalist  for Apprentice of the Year in the Norfolk Apprenticeship Awards. 

Read more >
 
Andy Cammidge
24 Jan 2023

New research grant will investigate novel organic materials

Prof Andy Cammidge (CHE) and colleagues have been awarded £800k from the Engineering and Physical Sciences Research Council to investigate the synthesis of new...

Read more >
 
James Bevan presenting at UEA. He is wearing glasses, a black jacket and grey trousers.
24 Jan 2023

UEA praised for 'outstanding' work on climate research

Sir James Bevan, Chief Executive of the Environment Agency, praised UEA’s outstanding work on climate research and highlighted the need to focus on climate...

Read more >
 
Steve Smith holding his award up with another person. Steve is wearing a grey suit.
11 Jan 2023

Nur-sing when you’re winning

National nursing award announced for retired university academic Steve Smith, aka the ‘Singing Lecturer’.

Read more >