Project description

Primary supervisor - Dr Nick Talbot

What makes a plant killer lose its edge? This project will investigate why fungal pathogens lose virulence when they are grown in laboratory culture away from their host plant. Use cutting-edge molecular biology and genomics, we will try to solve a decades-old mystery in plant pathology.

Many plant disease-causing fungi lose their ability to cause disease if they are cultured for prolonged periods in artificial media away from their plant host. The reasons for this, however, are completely unknown, but probably linked to genomic rearrangements, transposon activity or perhaps epigenetic changes. This project will investigate the phenomenon using the rice blast fungus Magnaporthe (Syn. Pyricularia) oryzae, which destroys enough rice each year to feed 60 million people, threatening global food security.

We will identify the genetic and epigenetic changes associated with prolonged sub-culture of the blast fungus using comparative genome analysis and thereby define the mechanisms associated with loss of virulence, as well as identifying novel genetic determinants of pathogenicity.

The project will provide broad training in molecular genetics, genomics, cell biology, and plant-microbe interactions. Intellectually, the project provides a challenge in understanding how genomic instability reshapes fungal virulence in a plant pathogenic fungus.

The Norwich Research Park Biosciences Doctoral Training Programme (NRPDTP) is offering fully funded studentships for October 2026 entry. The programme offers postgraduates the opportunity to undertake a 4-year PhD research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP students undertake a three-month professional internship placement (PIPS) during their study. The placement offers exciting and invaluable work experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team.

This project has been shortlisted for funding by the NRPDTP. Shortlisted applicants will be interviewed on 3,4 or 5 February 2026.

Visit our website for further information on eligibility and how to apply: https://biodtp.norwichresearchpark.ac.uk/.

Our partners value diverse and inclusive work environments that are positive and supportive. Students are selected for admission without regard to gender, marital or civil partnership status, disability, race, nationality, ethnic origin, religion or belief, sexual orientation, age or social background.

To maximise accessibility and attract students from underrepresented groups to our programme we have introduced bespoke templates for applicant Personal and Research statements which will enable every applicant to fully represent themselves through providing suitable examples and evidence. These forms are on the NRPDTP website and must be used for these sections of the application form.

Entry requirements

At least UK equivalence Bachelors (Honours) 2:1. English Language requirement (Faculty of Science equivalent: IELTS 6.5 overall, 6 in each category).

Funding

This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship. The studentship includes payment of tuition fees (directly to the University), a stipend to cover living expenses (2025/6 stipend rate: £20,780), and a Research Training Support Grant of £5,000pa for each year of the studentship.

References

Yan X, Tang B, Ryder LS, MacLean D, Were VM, Eseola AB, Cruz-Mireles N, Ma W, Foster AJ, Osés-Ruiz M, Talbot NJ. (2023) The transcriptional landscape of plant infection by the rice blast fungus Magnaporthe oryzae reveals distinct families of temporally co-regulated and structurally conserved effectors. Plant Cell. 35:1360-1385.

Tang, B., Yan, X., Ryder, LS., Bautista, M-J., Cruz-Mireles, N., Soanes, DM., Molinari, C., Foster, AJ., Talbot NJ. (2023) Rgs1 is a regulator of effector gene expression during plant infection by the rice blast fungus Magnaporthe oryzae Proc. Natl. Acad. Sci USA 120:e2301358120

Cruz-Mireles, N, Osés-Ruiz, M, Derbyshire, P, Jégousse, C, Ryder, LS, Bautista, MJ, Eseola, AB, Sklenar, J, Tang, B, Yan, X, Ma, W, Findlay, KC, Were, V, MacLean, D, Talbot, NJ, Menke, FLH (2024) The phosphorylation landscape of infection-related development by the rice blast fungus Cell 187: 2557-73

Attah V, Milner DS, Fang Y, Yan X, Leonard G, Heitman J, Talbot NJ, Richards TA. (2024) Duplication

and neofunctionalization of a horizontally-transferred xyloglucanase as a facet of the red queen coevolutionary

dynamic Proc. Natl. Acad. Sci USA 121:e2218927121.

Were VM, Yan X, Foster AJ, Sklenar J, Langner T, Gentle A, Sahu N, Bentham A, Zdrzałek R, Ryder LS, Kaimenyi DK, De La Cruz DG, Petit-Houdenot Y, Eseola AB, Smoker M, Bautista MJ, Ma W, Kourelis J, Maclean D, Banfield MJ, Kamoun S, Menke FLH, Moscou MJ, Talbot NJ. (2025) The Magnaporthe oryzae effector Pwl2 alters HIPP43 localization to suppress host immunity. Plant Cell. 37(6):koaf116.

Vanishing Virulence: Investigating pathogenicity loss in a plant pathogenic fungus (TALBOT_T26DTP)

Project description

Entry requirements

Funding

References