Genomic Insights into Enhancing Detection and Characterisation of Neglected GI Pathogens (MATHER_Q25NIHR)
Key Details
- Application deadline
- 17 July 2025 (midnight UK time)
- Location
- UEA
- Funding type
- Directly Funded project (UK/Home students only)
- Start date
- 1 October 2025
- Mode of study
- Full-time
- Programme type
- PhD
Project description
Primary supervisor - Professor Alison Mather
Neglected gastrointestinal (GI) pathogens are responsible for a significant proportion of diarrheal disease cases that remain unattributed due to diagnostic gaps. The introduction of molecular diagnostic platforms has revealed a wide range of GI pathogens circulating in the community below the surveillance radar, raising questions about their clinical significance and public health impact.
The study will utilise genomics and metagenomics to examine the pathogenic potential and spread of neglected GI pathogens. Particular emphasis will be placed on understanding genetic traits, such as virulence markers and antimicrobial resistance (AMR), that could contribute to transmission dynamics. The findings will enhance national surveillance strategies for emerging pathogens at UKHSA and facilitate the implementation of innovative surveillance methodologies, including monitoring emerging AMR, to achieve significant public health impact.
This project offers a combination of wet lab and dry lab approaches, providing hands-on experience with laboratory techniques such as pathogen isolation and DNA extraction, alongside bioinformatics training. Students will develop a unique skill set at the intersection of laboratory and computational approaches, preparing them for careers in public health microbiology and genomic research.
We are looking for a candidate with a strong background in microbiology, molecular biology, or a related field. Experience with genomic or bioinformatics techniques is desirable but not essential. The student will be based at Quadram Institute Bioscience, and will have the opportunity to spend time at the UK Health Security Agency Gastrointestinal Bacteria Reference Unit.
Entry requirements
At least UK equivalence Bachelors (Honours) 2:1 or UK equivalence Masters degree. English Language requirement (Faculty if Science equivalent: IELTS 6.5 overall, 6 in each category)
Funding
This project is awarded with a 4-year fully funded National Institute for Health and Care Research (NIHR) PhD studentship. This is open to Home Fee Status applicants only. Tuition fees at Home Rate only are covered, and a stipend will be provided for each year of the studentship (2025/6 rate is £20,780.00). Research training support funding is available.
For further information and to apply, please visit our website.