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Fluorescent Biological Probes for Epigenetic Targets
A novel method that allows the production of chemically labelled biological probes valuable for investigating and analysing epigenetic targets in disease. The innovation allows the creation of uniquely designed cell-permeable and chemically-labelled probes that can adhere to and inhibit specific key target molecules involved in epigenetic regulation and disease. A major advantage is that the probes can be labelled with fluorescent or non-fluorous tags which facilitate imaging and detection techniques in investigative and analytical biological research.
Advantages
cell-permeable probes
capable of non-fluorous or fluorescent labelling
high-affinity inhibitors of key epigenetic targets
solves issue of limited availability and diversity of epigenetic probes.
Scientists at the University of East Anglia offer these unique epigenetic probes with customisable options. This technology and the resulting availability of new epigenetic probes will help researchers determine the role of epigenetic targets in epigenetic regulation and disease. It will also help elucidate the key mechanisms and give rise to other key components involved which will help develop new, safe and effective drugs and therapies for treating and preventing disease in humans.
Publications
Bioorg. Med. Chem. 19 (2011) 3709–3716. doi:10.1016/j.bmc.2011.02.017
Principal Investigator
Team led by Professor A. Ganesan
Further Details
For more information on this licensing opportunity, please contact the IP Office.