Understanding biological function Understanding biological function

We focus on the treatment of human disorders by a mechanistic understanding of cellular receptors and signalling pathways, with an emphasis on cancer, immunology and inflammation.

Our key research themes are inflammation in human diseases such as septic shock or retinitis, chemotaxis, cell-cell communication, carcinogenesis, antioxidant response and the cellular mechanisms underlying retinal damage and glaucoma.

Among the molecular targets being studied are G-protein coupled receptors, chemokine receptors, Nrf2 and the Wnt signalling pathway


Dr Peter McCormick

Dr Peter McCormick

  • Ageing related diseases and G-Protein Coupled Receptors (GPCR)
  • Cellular mechanisms of Neurodegeneration
  • GPCR heteromers and their role in the Central Nervous System
  • Basic mechanisms of cancer proliferation and migration

Dr Anja Mueller

  • Chemokine receptor signalling mechanisms
  • G-protein-coupled receptor (GPCR) function
  • Novel GPCR detection methods

Dr Maria O'Connell

  • Inflammatory gene control of macrophage and monocyte function
  • Control of antioxidant genes in normal and diseased states
  • Changes in inflammation processes in chronic inflammatory conditions such as septic shock

Dr Julie Sanderson

  • Cellular mechanisms underlying retinal ganglion cell neurodegeneration in glaucoma; identification of targets for neuroprotection

  • Involvement of purinergic signalling in ocular disease

  • Development of ex vivo human tissue models for study of ocular disease and ocular toxicology