Synthesis of functional molecules Synthesis of functional molecules

We are at the forefront of applying organic synthesis for medicinal chemistry applications ranging from chemical biology and target identification and validation to lead discovery, hit-to-lead optimisation to sensors and supramolecular chemistry.
 
Among our areas of expertise are higher order DNA structures, biologically active natural products, epigenetics, microbial biochemistry and multivalent drug delivery systems. We are experienced in the synthesis of a variety of small molecules as well as peptides and nucleic acids.
 

Staff

Prof Ganesan

Prof Ganesan

  • Organic synthesis of biologically active natural products
  • Synthesis of epigenetic enzyme inhibitors
  • Synthesis of therapeutically relevant protease inhibitors, calcium signalling probes and antibiotics

Dr Chris Hamilton

Dr Chris Hamilton

  • Chemical and biochemical functions of low molecular weight thiols in Gram positive bacteria.
  • Redox mechanisms of bioactive organosulfur metabolites from garlic
  • Mechanistic enzymology

Dr Lesley Howell

Dr Lesley Howell

  • Investigation of protein-protein interactions associated with cancer
  • Synthesis of small molecules to inhibit protein-protein interactions
  • Synthesis of novel antibacterial agents targeting DNA gyrase

Dr Susan Matthews

Dr Susan Matthews

  • Gene delivery through functionalised multicalixarenes
  • Site-specific pro-drug systems for new anti-cancer agents
  • Synthesis of new macrocyclic systems

Dr Paul McDermott

Dr Paul McDermott

  • Synthesis of Analogues of Symplostatin 4 for QSAR studies
  • Synthesis of Analogues of Simocyclinone D8 as potential antiobiotic compounds
  • Development of Novel E-learning resources for Undergraduate Pharmacy Students

Prof Mark Searcey

Prof Mark Searcey

  • Inhibition of protein-DNA and protein-protein interactions
  • Targeting nucleic acid and DNA repair and proliferation
  • Solution and solid phase natural product synthesis from synthetic sources

Dr Zoë Waller

Dr Zoë Waller

  • Targeting alternative DNA structures with small molecule ligands/drugs
  • Investigating the effects of alternative nucleic acid secondary structures in biology
  • Studying conformational switching of DNA using cations and ligands