Biography

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Yaroslav Khimyak has moved to a Chair in solid-state NMR spectroscopy in the School of Pharmacy in UEA in September 2011. Until then he was a Senior Lecturer at the Department of Chemistry in the University of Liverpool where he was appointed as a Lecturer in 2002. Yaroslav graduated from Ivan Franko Lviv State University in the Ukraine with an M.Sc. in Chemistry (1994), obtained an M. Phil. (1997) and a Ph. D. (2000) from the University of Cambridge and held a position of Oppenheimer Research Fellow at the Department of Chemistry in the University of Cambridge (1999 – 2002).

The research in Yaroslav’s group focuses on understanding structure and dynamics of materials with limited long range ordering using solid-state NMR and demonstrated the importance of characterisation of dynamics on different time scales for ratioanalising the properties of such complex solids. The materials of interest include pharmaceutical solids (polymer/drug composites, amorphous pharmaceuticals) and porous materials (polymers, hybrid silicas, MOFs). Our interest in the application of modern solid-state NMR methodology to elucidate the structure of “soft” solids has attracted industrial support to study amorphous polymer-based materials used for the controlled drug release and glasses.

Yaroslav Khimyak is the Head of NMR at Norwich Research Group steering group.

Selected publications

An Adaptable Peptide-Based Porous Material
J. Rabone, Y. F. Yue, S. Y. Chong, K. C. Stylianou, J. Bacsa, D. Bradshaw, G. R. Darling, N. G. Berry, Y. Z. Khimyak, A. Y. Ganin, P. Wiper, J. B. Claridge, and M. J. Rosseinsky.
Science, 2010, 329, 1053-1057.
DOI:10.1126/science.119067

Effect of encapsulating a pseudo-decapeptide containing arginine on PLGA: a solid-state NMR study
J. B. Guilbaud, B. C. Clark, E. Meehan, L. Hughes, A. Saiani and Y. Z. Khimyak.
Journal of Pharmaceutical Sciences, 2010, 99, 2697-2710.
DOI: 10.1002/jps.22060

Amorphous Drug-PVP Dispersions: Application of Theoretical, Thermal and Spectroscopic Analytical Techniques to the Study of a Molecule with Intermolecular Bonds in Both the Crystalline and Pure Amorphous State
M. Tobyn, J. Brown, A. B. Dennis, M. Fakes, Q. Gao, J. Gamble, Y. Z. Khimyak, G. McGeorge, C. Patel, W. Sinclair, P. Timmins and S. Yin
Journal of Pharmaceutical Sciences, 2009, 98, 3456-3468.
DOI: 10.1002/jps.21738

Periodic mesoporous organosilicas with domain functionality: Synthesis and advanced characterization
J. T. A. Jones, C. D. Wood, C. Dickinson and Y. Z. Khimyak
Chemistry of Materials, 2008, 20, 3385-3397.
DOI: 10.1021/cm7036124

All Publications

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Ramalhete, S., Nartowski, K., Sarathchandra, N., Foster, J., Round, A., Angulo Alvarez, J., Lloyd, G., Khimyak, Y.

(2017)

Supramolecular amino acid based hydrogels: probing the contribution of additive molecules using NMR spectroscopy,

in Chemistry - A European Journal

23

(33)

pp. 8014–8024

Full Text UEA Repository

(Article)

(Published)


Ramalhete, S. M., Foster, J. S., Green, H. R., Nartowski, K. P., Heinrich, M., Martin, P. C., Khimyak, Y. Z., Lloyd, G. O.

(2017)

Halogen effects on the solid-state packing of phenylalanine derivatives and the resultant gelation properties,

in Faraday Discussions

Full Text UEA Repository

(Article)

(E-pub ahead of print)


Nartowski, K. P., Ramalhete, S. M., Martin, P. C., Foster, J. S., Heinrich, M., Eddleston, M. D., Green, H. R., Day, G. M., Khimyak, Y. Z., Lloyd, G. O.

(2017)

The Plot Thickens: Gelation by Phenylalanine in Water and Dimethyl Sulfoxide,

in Crystal Growth & Design

17

(8)

pp. 4100–4109

Full Text UEA Repository

(Article)

(Published)


Takieddin, K., Khimyak, Y., Fabian, L.

(2016)

Prediction of Hydrate and Solvate Formation Using Statistical Models,

in Crystal Growth & Design

16

(1)

pp. 70-81

Full Text UEA Repository

(Article)

(Published)


Braun, D., Nartowski, K., Khimyak, Y., Morris, K., Byrn, S., Griesser, U.

(2016)

Structural Properties, Order-Disorder Phenomena and Phase Stability of Orotic Acid Crystal Forms,

in Molecular Pharmaceutics

13

(3)

pp. 1012-1029

Full Text UEA Repository

(Article)

(Published)


Piana, F., Case, D. H., Campos E Menezes Jorge Ramalhete, S., Pileio, G., Facciotti, M., Day, G. M., Khimyak, Y., Angulo, J., Brown, R. C. D., Gale, P. A.

(2016)

Substituent interference on supramolecular assembly in urea gelators: synthesis, structure prediction and NMR,

in Soft Matter

12

(17)

pp. 4034-4043

Full Text UEA Repository

(Article)

(Published)


Nartowski, K., Khimyak, Y., Berry, D.

(2016)

Tuning the spontaneous formation kinetics of caffeine:malonic acid co-crystals,

in CrystEngComm

18

(15)

pp. 2617-2620

Full Text UEA Repository

(Article)

(Published)


Nartowski, K., Malhotra, D., Hawarden, L., Sibik, J., Iuga, D., Zeitler, J. A., Fabian, L., Khimyak, Y.

(2016)

19F NMR Spectroscopy as a Highly Sensitive Method for the Direct Monitoring of Confined Crystallization within Nanoporous Materials,

in Angewandte Chemie International Edition

128

(31)

pp. 9050-9054

Full Text UEA Repository

(Article)

(Published)


Rashid, A. M., Batey, S. F. D., Syson, K., Koliwer-Brandl, H., Miah, F., Barclay, J. E., Findlay, K. C., Nartowski, K. P., Khimyak, Y. Z., Kalscheuer, R., Bornemann, S.

(2016)

Assembly of α-Glucan by GlgE and GlgB in Mycobacteria and Streptomycetes,

in Biochemistry

55

(23)

pp. 3270-3284

Full Text UEA Repository

(Article)

(Published)


Piana, F., Case, D. H., Ramalhete, S. M., Pileio, G., Facciotti, M., Day, G. M., Khimyak, Y. Z., Angulo Alvarez, J., Brown, R. C. D., Gale, P. A.

(2016)

Correction: Substituent interference on supramolecular assembly in urea gelators: synthesis, structure prediction and NMR,

in Soft Matter

12

pp. 5489

Full Text UEA Repository

(Article)

(Published)


Hellrup, J., Holmboe, M., Nartowski, K. P., Khimyak, Y. Z., Mahlin, D.

(2016)

Structure and Mobility of Lactose in Lactose/Sodium Montmorillonite Nanocomposites,

in Langmuir

32

(49)

pp. 13214–13225

Full Text UEA Repository

(Article)

(Published)


Sarcevica, I., Orola, L., Nartowski, K., Khimyak, Y., Round, A., Fabian, L.

(2015)

Mechanistic and kinetic insight into spontaneous cocrystallisation of isoniazid and benzoic acid,

in Molecular Pharmaceutics

12

(8)

pp. 2981–2992

Full Text UEA Repository

(Article)

(Published)


Nartowski, K. P., Tedder, J., Braun, D. E., Fabian, L., Khimyak, Y. Z.

(2015)

Building solids inside nano-space: from confined amorphous through confined solvate to confined ‘metastable’ polymorph,

in Physical Chemistry Chemical Physics

17

(38)

pp. 24761-24773

Full Text UEA Repository

(Article)

(Published)


Algara-Siller, G., Severin, N., Chong, S. Y., Björkman, T., Palgrave, R. G., Laybourn, A., Antonietti, M., Khimyak, Y. Z., Krasheninnikov, A. V., Rabe, J. P., Kaiser, U., Cooper, A. I., Thomas, A., Bojdys, M. J.

(2014)

Triazine-Based Graphitic Carbon Nitride: a Two-Dimensional Semiconductor,

in Angewandte Chemie International Edition

53

(29)

pp. 7450-7455

Full Text UEA Repository

(Article)

(Published)


Laybourn, A., Dawson, R., Clowes, R., Hasell, T., Cooper, A. I., Khimyak, Y. Z., Adams, D. J.

(2014)

Network formation mechanisms in conjugated microporous polymers,

in Polymer Chemistry

5

(21)

pp. 6325-6333

Full Text UEA Repository

(Article)

(Published)


Martí-Gastaldo, C., Antypov, D., Warren, J., Briggs, M., Chater, P. A., Wiper, P. V., Miller, G. J., Khimyak, Y., Darling, G. R., Berry, N. G., Rosseinsky, M. J.

(2014)

Sidechain control of porosity closure in multiple peptide-based porous materials by cooperative folding,

in Nature Chemistry

6

(4)

pp. 343-351

Full Text UEA Repository

(Article)

(Published)


Laybourn, A., Dawson, R., Clowes, R., Iggo, J., Cooper, A., Khimyak, Y., Adams, D.

(2012)

Branching out with aminals: microporous organic polymers from difunctional monomers,

in Polymer Chemistry

3

(2)

pp. 533

Full Text UEA Repository

(Article)

(Published)


Leus, K., Vandichel, M., Liu, Y., Muylaert, I., Musschoot, J., Pyl, S., Vrielinck, H., Callens, F., Marin, G., Detavernier, C., Wiper, P., Khimyak, Y., Waroquier, M., Van Speybroeck, V., Van Der Voort, P.

(2012)

The coordinatively saturated vanadium MIL-47 as a low leaching heterogeneous catalyst in the oxidation of cyclohexene,

in Journal of Catalysis

285

(1)

pp. 196-207

Full Text UEA Repository

(Article)

(Published)


Ren, S., Bojdys, M., Dawson, R., Laybourn, A., Khimyak, Y., Adams, D., Cooper, A.

(2012)

Porous, Fluorescent, Covalent Triazine-Based Frameworks Via Room-Temperature and Microwave-Assisted Synthesis,

in Advanced Materials

24

(17)

pp. 2357-2361

Full Text UEA Repository

(Article)

(Published)


Ren, S., Dawson, R., Laybourn, A., Jiang, J., Khimyak, Y., Adams, D., Cooper, A.

(2012)

Functional conjugated microporous polymers: from 1,3,5-benzene to 1,3,5-triazine,

in Polymer Chemistry

3

(4)

pp. 928-934

Full Text UEA Repository

(Article)

(Published)


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Administrative Posts

Head of Pharmaceutical Materials and Drug Delivery Section