Biography

Derek graduated from the University of Dundee with a BSc (Hons) in Molecular Biology and Biochemistry. He obtained his PhD from the University of Glasgow studying the role of Sla1p in linking actin dynamics to the endocytic machinery in budding yeast. Following post-doctoral positions in the Division of Cardiovascular Medicine, University of Cambridge and the Cardiovascular Division, King’s College London, he won a Career Development Award from the King’s College London British Heart Foundation (BHF) Centre of Research Excellence in 2010. In 2011, Derek won a BHF Intermediate Fellowship to investigate novel mechanisms of smooth muscle cell mechanotransduction. His research focusses on understanding how cells sense and respond to changes in their extracellular environment using state-of-the-art biophysical, cell biological and imaging techniques. 

PhD positions
I currently have two PhD positions advertised in my lab:

Does blood vessel stiffness influence smooth muscle cell migrational capacity during vascular disease and ageing?

Using biomaterials to investigate nuclear deformation during confined cellular migration

Selected publications

Prelamin A Accumulation Attenuates Rac1 Activity and Increases the Intrinsic Migrational Persistence of Aged Vascular Smooth Muscle Cells
by Lauren J. Porter, Mark R. Holt, Daniel Soong, Catherine M. Shanahan and Derek T. Warren
Cells 2016, 5(4), 41;
DOI:10.3390/cells5040041

N-terminal nesprin-2 variants regulate β-catenin signalling.
Zhang Q, Minaisah RM, Ferraro E, Li C, Porter LJ, Zhou C, Gao F, Zhang J, Rajgor D, Autore F, Shanahan CM, Warren DT.
Exp Cell Res. 2016 Jul 15;345(2):168-79.
DOI: 10.1016/j.yexcr.2016.06.008.

The Use of Polyacrylamide Hydrogels to Study the Effects of Matrix Stiffness on Nuclear Envelope Properties.
Minaisah RM, Cox S, Warren DT.
Methods Mol Biol. 2016;1411:233-9.
DOI: 10.1007/978-1-4939-3530-7_15.

Nesprin-2-dependent ERK1/2 compartmentalisation regulates the DNA damage response in vascular smooth muscle cell ageing.
Warren DT, Tajsic T, Porter LJ, Minaisah RM, Cobb A, Jacob A, Rajgor D, Zhang QP, Shanahan CM.
Cell Death Differ. 2015 Sep;22(9):1540-50.
DOI: 10.1038/cdd.2015.12.

Nesprins LINC the nucleus and cytoskeleton.
Mellad JA, Warren DT, Shanahan CM.
Curr Opin Cell Biol. 2011 Feb;23(1):47-54.
DOI: 10.1016/j.ceb.2010.11.006. Review.

 

All Publications

Kokkinopoulos, I., Wong, M. M., Potter, C. M., Xie, Y., Yu, B., Warren, D. T., Nowak, W. N., Le Bras, A., Ni, Z., Zhou, C., Ruan, X., Karamariti, E., Hu, Y., Zhang, L., Xu, Q.

(2017)

Adventitial SCA-1+ Progenitor Cell Gene Sequencing Reveals the Mechanisms of Cell Migration in Response to Hyperlipidemia,

in Stem Cell Reports

9

(2)

pp. 681–696

Full Text UEA Repository

(Article)

(Published)


Zhou, C., Li, C., Zhou, B., Sun, H., Koullourou, V., Holt, I., Puckelwartz, M. J., Warren, D. T., Hayward, R., Lin, Z., Zhang, L., Morris, G. E., McNally, E. M., Shackleton, S., Rao, L., Shanahan, C. M., Zhang, Q.

(2017)

Novel nesprin-1 mutations associated with dilated cardiomyopathy cause nuclear envelope disruption and defects in myogenesis,

in Human Molecular Genetics

26

(12)

pp. 2258-2276

Full Text UEA Repository

(Article)

(Published)


Cobb, A. M., Larrieu, D., Warren, D., Liu, Y., Srivastava, S., Smith, A. J., Bowater, R. P., Jackson, S. P., Shanahan, C. M.

(2016)

Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient,

in Aging Cell

15

(6)

pp. 1039–1050

Full Text UEA Repository

(Article)

(Published)


Porter, L. J., Holt, M. R., Soong, D., Shanahan, C. M., Warren, D. T.

(2016)

Prelamin A Accumulation Attenuates Rac1 Activity and Increases the Intrinsic Migrational Persistence of Aged Vascular Smooth Muscle Cells,

in Cells

5

(4)

article no. 41

Full Text UEA Repository

(Article)

(Published)


Yu, B., Wong, M. M., Potter, C. M. F., Simpson, R. M. L., Karamariti, E., Zhang, Z., Zeng, L., Warren, D., Hu, Y., Wang, W., Xu, Q.

(2016)

Vascular Stem/Progenitor Cell Migration Induced by Smooth Muscle Cell-Derived Chemokine (C-C Motif) Ligand 2 and Chemokine (C-X-C motif) Ligand 1 Contributes to Neointima Formation,

in Stem Cells

34

(9)

pp. 2368-2380

Full Text UEA Repository

(Article)

(Published)


Zhang, Q., Minaisah, R., Ferraro, E., Li, C., Porter, L. J., Zhou, C., Gao, F., Zhang, J., Rajgor, D., Autore, F., Shanahan, C. M., Warren, D. T.

(2016)

N-terminal nesprin-2 variants regulate β-catenin signalling,

in Experimental Cell Research

345

(2)

pp. 168-179

Full Text UEA Repository

(Article)

(Published)


Minaisah, R. M., Cox, S., Warren, D. T.

(2016)

The use of polyacrylamide hydrogels to study the effects of matrix stiffness on nuclear envelope properties,

in Methods in Molecular Biology.

Springer

pp. 233-239

ISBN 978-1-4939-3528-4

Full Text UEA Repository

(Chapter)

(Published)


Simpson, R. M. L., Hong, X., Wong, M. M., Karamariti, E., Bhaloo, S. I., Warren, D., Kong, W., Hu, Y., Xu, Q.

(2016)

Hyaluronan is crucial for stem cell differentiation into smooth muscle lineage,

in Stem Cells

34

(5)

pp. 1225-1238

Full Text UEA Repository

(Article)

(Published)


Cobb, A. M., Murray, T. V., Warren, D. T., Liu, Y., Shanahan, C. M.

(2016)

Disruption of PCNA-lamins A/C interactions by prelamin A induces DNA replication fork stalling,

in Nucleus

7

(5)

pp. 498-511

Full Text UEA Repository

(Article)

(Published)


Warren, D. T., Tajsic, T., Porter, L. J., Minaisah, R. M., Cobb, A., Jacob, A., Rajgor, D., Zhang, Q. P., Shanahan, C. M.

(2015)

Nesprin-2-dependent ERK1/2 compartmentalisation regulates the DNA damage response in vascular smooth muscle cell ageing,

in Cell Death and Differentiation

22

(9)

pp. 1540-1550

Full Text UEA Repository

(Article)

(Published)


Anilkumar, N., Jose, G. S., Sawyer, I., Santos, C. X. C., Sand, C., Brewer, A. C., Warren, D., Shah, A. M.

(2013)

A 28-kDa splice variant of NADPH oxidase-4 is nuclear-localized and involved in redox signaling in vascular cells,

in Arteriosclerosis, Thrombosis, and Vascular Biology

33

(4)

pp. e104-e112

Full Text UEA Repository

(Article)

(Published)


Warren, D. T., Shanahan, C. M.

(2011)

Defective DNA-damage repair induced by nuclear lamina dysfunction is a key mediator of smooth muscle cell aging,

in Biochemical Society Transactions

39

(6)

pp. 1780-1785

Full Text UEA Repository

(Article)

(Published)


Mellad, J. A., Warren, D. T., Shanahan, C. M.

(2011)

Nesprins LINC the nucleus and cytoskeleton,

in Current Opinion in Cell Biology

23

(1)

pp. 47-54

Full Text UEA Repository

(Article)

(Published)


Ragnauth, C. D., Warren, D. T., Liu, Y., McNair, R., Tajsic, T., Figg, N., Shroff, R., Skepper, J., Shanahan, C. M.

(2010)

Prelamin a acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging,

in Circulation

121

(20)

pp. 2200-2210

Full Text UEA Repository

(Article)

(Published)


Warren, D. T., Tajsic, T., Mellad, J. A., Searles, R., Zhang, Q., Shanahan, C. M.

(2010)

Novel nuclear nesprin-2 variants tether active extracellular signal-regulated MAPK1 and MAPK2 at promyelocytic leukemia protein nuclear bodies and act to regulate smooth muscle cell proliferation,

in Journal of Biological Chemistry

285

(2)

pp. 1311-1320

Full Text UEA Repository

(Article)

(Published)