Biography

PhD Positions

Click here for current PhD opportunities in PHA. But feel free to email me to discuss projects outside these areas and alternative sources of funding.

Chris graduated with an MPharm degree (First Class Honours) from Cardiff University in 2002. He then undertook PhD studies in which he investigated the mechanistic aspects of macromolecule uptake and transport across the lung epithelium. In 2007 Chris assumed a post-doctoral position on the EPSRC-funded Nanomedicine Platform Grant (Departments of Chemistry & Pharmacy, Cardiff University) where he led a small inter-disciplinary research group looking at the design and synthesis of novel nanomedicines for enhanced pulmonary macromolecule delivery. Subsequently, Chris worked with scientists from the Defence & Science Technology Laboratory (Porton Down, UK) on a collaborative project that investigated the bioavailability of antimicrobial peptides following delivery into the intact lung. In September 2010 Chris joined UEA as a Lecturer in Drug Delivery and Pharmaceutics.

Chris’ main research interests are in the area of experimental peptide therapeutics (including antimicrobial peptides) focussing specifically on their disposition at biological barriers. Current projects include:

  • The examination of antimicrobial peptide and nanomaterial disposition in the airways
  • The development of polymer-peptide platforms for delivery of biologically active peptide drugs across the mucosal barriers of the gut and the lung
  • Development of cellular and non-cellular model systems for studying macromolecule interactions with mucosal barriers
  • The use of phage display to identify DNA-binding ligands (collaboration with Dr Zoe Waller)

Current Group Members

Dr Amalia Ruiz (Post-doc)

Mohammad Akbar (PhD Student)

Sandeep Bahia (PhD student)

Melania Giorgetti (PhD student)

Daniela Nobre Salvador (joint PhD student, Dundee)

 

Selected publications

Antimicrobial Nanoplexes meet Model Bacterial Membranes:the key role of cardiolipin

Marín-Menéndez A, Montis C, Díaz-Calvo T, Carta D, Hatzixanthis K, Morris CJ, McArthur M, Berti D

Sci. Rep. 2017; 7: 41242.  doi: 10.1038/srep41242

Selectivity in the Impact of P-Glycoprotein Upon Pulmonary Absorption of Airway-Dosed Substrates: A Study in Ex Vivo Lung Models Using Chemical Inhibition and Genetic Knockout

Al-Jayyoussi, Ghaith, Price, Daniel F, Francombe, Danielle, Taylor, Glyn, Smith, Mathew W, Morris, Chris, Edwards, Chris D, Eddershaw, Peter, Gumbleton, Mark

J. Pharm. Sci., 2013 102(9):3382-94.
DOI: 10.1002/jps.23587

Maximal extent of translocation of single-walled carbon nanotubes from lung airways of the rat
Matthews IP, Gregory CJ, Aljayyoussi G, Morris CJ, McDonald I, Hoogendoorn B, Gumbleton M
Environ Toxicol Pharmacol., 2013, 35(3):461-464.
DOI: 10.1016/j.etap.2013.02.002

Enhanced pulmonary absorption of a macromolecule through coupling to a sequence-specific phage display-derived peptide.
Morris CJ, Smith MW, Griffiths PC, McKeown NB, Gumbleton M.
Journal of Controlled Release, 2011, 151 (1). pp. 83-94.
DOI:10.1016/j.jconrel.2010.12.003

Pegylation of antimicrobial peptide maintains the active peptide conformation, model membrane interactions and antimicrobial activity while improving lung tissue biocompatibility following airway delivery.
Antimicrobial Agents and Chemotherapy, 2012, 56 (6). pp. 3298-3308.
DOI:10.1128/AAC.06335-11

Spatial expression and functionality of drug transporters in the intact lung: Objectives for further research.
M. Gumbleton, G.Al-Jayyoussi, A. Crandon-Lewis, D. Francombe, K. Kreitmeyr, C.J. Morris & M. Smith.
Advanced Drug Delivery Reviews, 2010, 63 (1-2). pp. 110-118.
DOI: 10.1016/j.addr.2010.09.008

PGSE-NMR and SANS studies of the interaction of model polymer therapeutics with mucin.
P.C. Griffiths, P. Occhipinti, C.J. Morris, Heenan R, King S, Gumbleton M
Biomacromolecules. 2010, 11, 120-125
DOI: 10.1021/bm9009667

 

All Publications

Marin-Barba, M., Gavilán, H., Gutierrez, L., Lozano Velasco, E., Rodriguez Ramiro, I., Wheeler, G., Morris, C. J., Puerto Morales, M., Ruiz, A.

(2018)

Unravelling the mechanisms that determine the uptake and metabolism of magnetic single and multicore nanoparticles in a Xenopus laevis model.,

in Nanoscale

10

(2)

pp. 690-704

Full Text UEA Repository

(Article)

(Published)


Morris, C. J., Aljayyoussi, G., Mansour, O., Griffiths, P., Gumbleton, M.

(2017)

Endocytic uptake, transport and macromolecular interactions of anionic PAMAM dendrimers within lung tissue,

in Pharmaceutical Research

34

(12)

pp. 2517–2531

Full Text UEA Repository

(Article)

(Published)


Mamusa, M., Sitia, L., Barbero, F., Ruyra, A., Díaz Calvo, T., Montis, C., Gonzalez-Paredes, A., Wheeler, G. N., Morris, C. J., McArthur, M., Berti, D.

(2017)

Cationic liposomal vectors incorporating a bolaamphiphile for oligonucleotide antimicrobials,

in Biochimica et Biophysica Acta (BBA) - Biomembranes

1859

(10)

pp. 1767–1777

Full Text UEA Repository

(Article)

(Published)


Marín-Menéndez, A., Montis, C., Díaz-Calvo, T., Carta, D., Hatzixanthis, K., Morris, C. J., McArthur, M., Berti, D.

(2017)

Antimicrobial Nanoplexes meet Model Bacterial Membranes: the key role of Cardiolipin,

in Scientific Reports

7

(1)

article no. 41242

Full Text UEA Repository

(Article)

(Published)


Ulaeto, D. O., Morris, C. J., Fox, M. A., Gumbleton, M., Beck, K.

(2016)

Destabilization of α-helical structure in solution improves bactericidal activity of antimicrobial peptides: Opposing effects on bacterial and viral targets,

in Antimicrobial Agents and Chemotherapy

60

(4)

pp. 1984-1991

Full Text UEA Repository

(Article)

(Published)


Aljayyoussi, G., Price, D. F., Kreitmeyr, K., Keogh, J. P., Smith, M. W., Gumbleton, M., Morris, C. J.

(2015)

Absorption of ipratropium and L-carnitine into the pulmonary circulation of the ex-vivo rat lung is driven by passive processes rather than active uptake by OCT/OCTN transporters,

in International Journal of Pharmaceutics

496

(2)

pp. 834-841

Full Text UEA Repository

(Article)

(Published)


Al-Jayyoussi, G., Price, D. F., Francombe, D., Taylor, G., Smith, M. W., Morris, C., Edwards, C. D., Eddershaw, P., Gumbleton, M.

(2013)

Selectivity in the impact of P-glycoprotein upon pulmonary absorption of airway-dosed substrates: A study in ex vivo lung models using chemical inhibition and genetic knockout,

in Journal of Pharmaceutical Sciences

102

(9)

pp. 3382-3394

Full Text UEA Repository

(Article)

(Published)


Matthews, I., Gregory, C., Aljayyoussi, G., Morris, C., Mcdonald, I., Hoogendoorn, B., Gumbleton, M.

(2013)

Maximal extent of translocation of single-walled carbon nanotubes from lung airways of the rat,

in Environmental Toxicology and Pharmacology

35

(3)

pp. 461-464

Full Text UEA Repository

(Article)

(Published)


Morris, C., Beck, K., Fox, M., Ulaeto, D., Clark, G., Gumbleton, M.

(2012)

Pegylation of Antimicrobial Peptides Maintains the Active Peptide Conformation, Model Membrane Interactions, and Antimicrobial Activity while Improving Lung Tissue Biocompatibility following Airway Delivery,

in Antimicrobial Agents and Chemotherapy

56

(6)

pp. 3298-3308

Full Text UEA Repository

(Article)

(Published)


Morris, C., Smith, M., Griffiths, P., McKeown, N., Gumbleton, M.

(2011)

Enhanced pulmonary absorption of a macromolecule through coupling to a sequence-specific phage display-derived peptide,

in Journal of Controlled Release

151

(1)

pp. 83-94

Full Text UEA Repository

(Article)

(Published)


Gumbleton, M., Al-Jayyoussi, G., Crandon-Lewis, A., Francombe, D., Kreitmeyr, K., Morris, C., Smith, M.

(2010)

Spatial expression and functionality of drug transporters in the intact lung: Objectives for further research☆,

in Advanced Drug Delivery Reviews

63

(1-2)

pp. 110-118

Full Text UEA Repository

(Article)

(Published)


Griffiths, P., Occhipinti, P., Morris, C., Heenan, R., King, S., Gumbleton, M.

(2010)

PGSE-NMR and SANS Studies of the Interaction of Model Polymer Therapeutics with Mucin,

in Biomacromolecules

11

(1)

pp. 120-125

Full Text UEA Repository

(Article)

(Published)


External Activities and Indicators of Esteem

  • Refereeing for J. Drug Target., J. Pharm. Sci., Pharm, Res,, Biosens & Bioelec, Adv, Drug Deliv, Rev., JCIS, Biochem. J., Int. J. Pharm.
  • Grant reviewer for AICR, BBSRC, EPSRC, Cancer Research Wales
  • Editorial board member for BioImpacts
  • Invited Talks:
  • Irish Drug Delivery Network Cluster Conference, , 2010. Presentation entitled “Peptide-polymer conjugates: experimental pulmonary therapeutics and enabling technologies for macromolecular drug delivery”
  • 2nd EUFEPS Conference on Monoclonal Antibodies, Crowne Plaza Hotel, Heidelberg, Germany 3-6th June 2008. Lecture entitled “Antibody transport across biological barriers”
  • Roche Symposium for Leading Scientists of the Next Decade (March 14-16 2006, Basel). “Uptake of macromolecular via vesicular mechanisms present in pulmonary epithelial cells - Exploitation to achieve effective protein and peptide delivery”