Chris graduated with an MPharm degree (First Class Honours) from Cardiff University in 2002. He then undertook PhD studies in which he investigated the mechanistic aspects of macromolecule uptake and transport across the lung epithelium. In 2007 Chris assumed a post-doctoral position on the EPSRC-funded Nanomedicine Platform Grant (Departments of Chemistry & Pharmacy, Cardiff University) where he led a small inter-disciplinary research group looking at the design and synthesis of novel nanomedicines for enhanced pulmonary macromolecule delivery. Subsequently, Chris worked with scientists from the Defence & Science Technology Laboratory (Porton Down, UK) on a collaborative project that investigated the bioavailability of antimicrobial peptides following delivery into the intact lung. In September 2010 Chris joined UEA as a Lecturer in Drug Delivery and Pharmaceutics.
Chris’ main research interests are in the area of experimental peptide therapeutics (including antimicrobial peptides) focussing specifically on their disposition at biological barriers. Current projects include:
- The examination of antimicrobial peptide and nanomaterial disposition in the airways
- The development of polymer-peptide platforms for delivery of biologically active peptide drugs across the mucosal barriers of the gut and the lung
- Development of cellular and non-cellular model systems for studying macromolecule interactions with mucosal barriers
- The use of phage display to identify DNA-binding ligands (collaboration with Dr Zoe Waller)
Current Group Members
Dr Amalia Ruiz (Post-doc)
Mohammad Akbar (PhD Student)
Sandeep Bahia (PhD student)
Melania Giorgetti (PhD student)
Daniela Nobre Salvador (joint PhD student, Dundee)
Antimicrobial Nanoplexes meet Model Bacterial Membranes:the key role of cardiolipin
Marín-Menéndez A, Montis C, Díaz-Calvo T, Carta D, Hatzixanthis K, Morris CJ, McArthur M, Berti D
Sci. Rep. 2017; 7: 41242. doi: 10.1038/srep41242Selectivity in the Impact of P-Glycoprotein Upon Pulmonary Absorption of Airway-Dosed Substrates: A Study in Ex Vivo Lung Models Using Chemical Inhibition and Genetic Knockout
Al-Jayyoussi, Ghaith, Price, Daniel F, Francombe, Danielle, Taylor, Glyn, Smith, Mathew W, Morris, Chris, Edwards, Chris D, Eddershaw, Peter, Gumbleton, Mark
J. Pharm. Sci., 2013 102(9):3382-94.
Maximal extent of translocation of single-walled carbon nanotubes from lung airways of the rat
Matthews IP, Gregory CJ, Aljayyoussi G, Morris CJ, McDonald I, Hoogendoorn B, Gumbleton M
Environ Toxicol Pharmacol., 2013, 35(3):461-464.
Enhanced pulmonary absorption of a macromolecule through coupling to a sequence-specific phage display-derived peptide.
Morris CJ, Smith MW, Griffiths PC, McKeown NB, Gumbleton M.
Journal of Controlled Release, 2011, 151 (1). pp. 83-94.
Pegylation of antimicrobial peptide maintains the active peptide conformation, model membrane interactions and antimicrobial activity while improving lung tissue biocompatibility following airway delivery.
Antimicrobial Agents and Chemotherapy, 2012, 56 (6). pp. 3298-3308.
Spatial expression and functionality of drug transporters in the intact lung: Objectives for further research.
M. Gumbleton, G.Al-Jayyoussi, A. Crandon-Lewis, D. Francombe, K. Kreitmeyr, C.J. Morris & M. Smith.
Advanced Drug Delivery Reviews, 2010, 63 (1-2). pp. 110-118.
PGSE-NMR and SANS studies of the interaction of model polymer therapeutics with mucin.
P.C. Griffiths, P. Occhipinti, C.J. Morris, Heenan R, King S, Gumbleton M
Biomacromolecules. 2010, 11, 120-125
Unravelling the mechanisms that determine the uptake and metabolism of magnetic single and multicore nanoparticles in a Xenopus laevis model.,
pp. 690-704Full Text UEA Repository
Endocytic uptake, transport and macromolecular interactions of anionic PAMAM dendrimers within lung tissue,
in Pharmaceutical Research
pp. 2517–2531Full Text UEA Repository
Cationic liposomal vectors incorporating a bolaamphiphile for oligonucleotide antimicrobials,
in Biochimica et Biophysica Acta (BBA) - Biomembranes
pp. 1767–1777Full Text UEA Repository
Antimicrobial Nanoplexes meet Model Bacterial Membranes: the key role of Cardiolipin,
in Scientific Reports
article no. 41242Full Text UEA Repository
Destabilization of α-helical structure in solution improves bactericidal activity of antimicrobial peptides: Opposing effects on bacterial and viral targets,
in Antimicrobial Agents and Chemotherapy
pp. 1984-1991Full Text UEA Repository
Absorption of ipratropium and L-carnitine into the pulmonary circulation of the ex-vivo rat lung is driven by passive processes rather than active uptake by OCT/OCTN transporters,
in International Journal of Pharmaceutics
pp. 834-841Full Text UEA Repository
Selectivity in the impact of P-glycoprotein upon pulmonary absorption of airway-dosed substrates: A study in ex vivo lung models using chemical inhibition and genetic knockout,
in Journal of Pharmaceutical Sciences
pp. 3382-3394Full Text UEA Repository
Maximal extent of translocation of single-walled carbon nanotubes from lung airways of the rat,
in Environmental Toxicology and Pharmacology
pp. 461-464Full Text UEA Repository
Pegylation of Antimicrobial Peptides Maintains the Active Peptide Conformation, Model Membrane Interactions, and Antimicrobial Activity while Improving Lung Tissue Biocompatibility following Airway Delivery,
in Antimicrobial Agents and Chemotherapy
pp. 3298-3308Full Text UEA Repository
Enhanced pulmonary absorption of a macromolecule through coupling to a sequence-specific phage display-derived peptide,
in Journal of Controlled Release
pp. 83-94Full Text UEA Repository
Spatial expression and functionality of drug transporters in the intact lung: Objectives for further research☆,
in Advanced Drug Delivery Reviews
pp. 110-118Full Text UEA Repository
PGSE-NMR and SANS Studies of the Interaction of Model Polymer Therapeutics with Mucin,
pp. 120-125Full Text UEA Repository
External Activities and Indicators of Esteem
- Refereeing for J. Drug Target., J. Pharm. Sci., Pharm, Res,, Biosens & Bioelec, Adv, Drug Deliv, Rev., JCIS, Biochem. J., Int. J. Pharm.
- Grant reviewer for AICR, BBSRC, EPSRC, Cancer Research Wales
- Editorial board member for BioImpacts
- Invited Talks:
- Irish Drug Delivery Network Cluster Conference, , 2010. Presentation entitled “Peptide-polymer conjugates: experimental pulmonary therapeutics and enabling technologies for macromolecular drug delivery”
- 2nd EUFEPS Conference on Monoclonal Antibodies, Crowne Plaza Hotel, Heidelberg, Germany 3-6th June 2008. Lecture entitled “Antibody transport across biological barriers”
- Roche Symposium for Leading Scientists of the Next Decade (March 14-16 2006, Basel). “Uptake of macromolecular via vesicular mechanisms present in pulmonary epithelial cells - Exploitation to achieve effective protein and peptide delivery”