Biography

PhD Positions

Click here for current PhD opportunities in PHA. But feel free to email me to discuss projects outside these areas and alternative sources of funding.

In 2003, I obtained BSc degree in Pharmacy from the HMU (ranking 1st). In 2010, I have gained PhD in Pharmacy from the University of Nottingham with Cameron Alexander, working on therapeutics polymers. Thereafter, I took up a postdoctoral research position at Network of Excellence for Functional Biomaterials (NUIG), focusing on fabrication of Bioactive Tissue Adhesives for wound healing. Following this time, In 2011 I took up a postdoctoral research position at The EPSRC Centre for Innovative Manufacturing in Regenerative Medicine, working with Kevin Shakesheff  and Cameron Alexander. In the latter, i focused on the development of Innovative Biomaterials (3D Matrices for Stem Cells Manufacturing) as multilateral collaborations across Nottingham, Loughborough and Keele Universities.

In August 2013, I took up a lecturer role in the School of Pharmacy at the University of East Anglia (UEA) to establish a new research group focusing on designing, fabrication, scale up and validation of Advanced Biomaterials for applications in Drug Delivery System (DDS), Tissue Engineering and Regenerative Medicine (TERM)

Selected Publications

A Thermoresponsive and Magnetic Colloid for 3D Cell Expansion and Reconfiguration.


Aram Saeed*, Nora Francini, Lisa White, James Dixon, Toby Gould, Hassan Rashidi, Racha Cheikh Al Ghanami, Veronika Hruschka, Heinz Redl, Brian R. Saunders, Cameron Alexander and Kevin M. Shakesheff

Advanced Materials, 2015.DOI: 10.1002/adma.201403626

 

A Clinical, Biological and Biomaterials Perspective into Tendon Injuries and Regeneration

Walden, G., Liao, X., Donell, S., Raxworthy, M. J., Riley, G. & Saeed, A. 2016 

Tissue Engineering Part B: Reviews.

 

A direct comparison of linear and star-shaped poly(dimethylaminoethyl acrylate) polymers for polyplexation with DNA and cytotoxicity in cultured cell lines

Liao, X., Walden, G., Falcon, N. D., Donell, S., Raxworthy, M., Wormstone, M., Riley, G. P. & Saeed, A.2016 In : European Polymer Journal.

 

The reverse of polymer degradation: in situ crosslinked gel formation through disulfide cleavage

Saeed, A. O., Newland, B., Pandit, A. & Wang, W. X

Chemical Communications, 2012 48, 585-587.

 

Modular Construction of Multifunctional Bioresponsive Cell-Targeted Nanoparticles for Gene Delivery.

Saeed, A. O., Magnusson, J. P., Moradi, E., Soliman, M., Wang, W. X., Stolnik, S., Thurecht, K. J., Howdle, S. M. & Alexander, C.

Bioconjugate Chemistry, 2011, 22, 156-168.

 

One-pot controlled synthesis of biodegradable and biocompatible co-polymer micelles.

Saeed, A. O., Dey, S., Howdle, S. M., Thurecht, K. J. & Alexander, C.

Journal of Materials Chemistry, 2009, 19, 4529-4535.

Highlighted Publications

See All

Liao, X., Walden, G., Falcon, N. D., Donell, S., Raxworthy, M., Wormstone, M., Riley, G. P., Saeed, A.

(2017)

A direct comparison of linear and star-shaped poly(dimethylaminoethyl acrylate) polymers for polyplexation with DNA and cytotoxicity in cultured cell lines,

in European Polymer Journal

87.

pp. 458–467

Full Text UEA Repository

(Article)

(Published)


Walden, G., Liao, X., Donell, S., Raxworthy, M. J., Riley, G., Saeed, A.

(2017)

A Clinical, Biological, and Biomaterials Perspective into Tendon Injuries and Regeneration,

in Tissue Engineering Part B: Reviews

23.

pp. 44-58

Full Text

(Literature review)

(Published)


Hruschka, V., Saeed, A., Slezak, P., Cheikh Al Ghanami, R., Feichtinger, G. A., Alexander, C., Redl, H., Shakesheff, K., Wolbank, S.

(2015)

Evaluation of a thermoresponsive polycaprolactone scaffold for in vitro three-dimensional stem cell differentiation,

in Tissue engineering. Part A

21.

pp. 310-319

Full Text UEA Repository

(Article)

(Published)


Hruschka, V., Meinl, A., Saeed, A., Cheikh Al Ghanami, R., Redl, H., Shakesheff, K., Wolbank, S.

(2013)

Gelatin embedding for the preparation of thermoreversible or delicate scaffolds for histological analysis,

in Biomedical Materials

8.

pp. 041001

Full Text UEA Repository

(Article)

(Published)


Saeed, A. O., Newland, B., Pandit, A., Wang, W.

(2012)

The reverse of polymer degradation: in situ crosslinked gel formation through disulfide cleavage,

in Chemical Communications

48.

pp. 585-587

Full Text UEA Repository

(Article)

(Published)


Dong, Y., Hassan, W., Zheng, Y., Saeed, A. O., Cao, H., Tai, H., Pandit, A., Wang, W.

(2012)

Thermoresponsive hyperbranched copolymer with multi acrylate functionality for in situ cross-linkable hyaluronic acid composite semi-IPN hydrogel,

in Journal of Materials Science-Materials in Medicine

23.

pp. 25-35

Full Text UEA Repository

(Article)

(Published)


Dong, Y., Saeed, A. O., Hassan, W., Keigher, C., Zheng, Y., Tai, H., Pandit, A., Wang, W.

(2012)

“One-step” Preparation of Thiol-Ene Clickable PEG-Based Thermoresponsive Hyperbranched Copolymer for In Situ Crosslinking Hybrid Hydrogel,

in Macromolecular Rapid Communications

33.

pp. 120-126

Full Text UEA Repository

(Article)

(Published)


All Publications

See Highlights

Liao, X., Walden, G., Falcon, N. D., Donell, S., Raxworthy, M., Wormstone, M., Riley, G. P., Saeed, A.

(2017)

A direct comparison of linear and star-shaped poly(dimethylaminoethyl acrylate) polymers for polyplexation with DNA and cytotoxicity in cultured cell lines,

in European Polymer Journal

87

pp. 458–467

Full Text UEA Repository

(Article)

(Published)


Walden, G., Liao, X., Donell, S., Raxworthy, M. J., Riley, G., Saeed, A.

(2017)

A Clinical, Biological, and Biomaterials Perspective into Tendon Injuries and Regeneration,

in Tissue Engineering Part B: Reviews

23

(1)

pp. 44-58

Full Text

(Literature review)

(Published)


Hruschka, V., Saeed, A., Slezak, P., Cheikh Al Ghanami, R., Feichtinger, G. A., Alexander, C., Redl, H., Shakesheff, K., Wolbank, S.

(2015)

Evaluation of a thermoresponsive polycaprolactone scaffold for in vitro three-dimensional stem cell differentiation,

in Tissue engineering. Part A

21

(1-2)

pp. 310-319

Full Text UEA Repository

(Article)

(Published)


Saeed, A., Francini, N., White, L., Dixon, J., Gould, T., Rashidi, H., Al Ghanami, R. C., Hruschka, V., Redl, H., Saunders, B. R., Alexander, C., Shakesheff, K. M.

(2015)

A thermoresponsive and magnetic colloid for 3D cell expansion and reconfiguration,

in Advanced Materials

27

(4)

pp. 662–668

Full Text UEA Repository

(Article)

(Published)


Sicilia, G., Grainger-boultby, C., Francini, N., Magnusson, J. P., Saeed, A. O., Fernández-trillo, F., Spain, S. G., Alexander, C.

(2014)

Programmable polymer-DNA hydrogels with dual input and multiscale responses,

in Biomaterials Science

2

pp. 203-211

Full Text UEA Repository

(Article)

(Published)


Hruschka, V., Meinl, A., Saeed, A., Cheikh Al Ghanami, R., Redl, H., Shakesheff, K., Wolbank, S.

(2013)

Gelatin embedding for the preparation of thermoreversible or delicate scaffolds for histological analysis,

in Biomedical Materials

8

(4)

pp. 041001

Full Text UEA Repository

(Article)

(Published)


Rahman, C. V., Saeed, A., White, L. J., Gould, T. W. A., Kirby, G. T. S., Sawkins, M. J., Alexander, C., Rose, F. R. A. J., Shakesheff, K. M.

(2012)

Chemistry of Polymer and Ceramic-Based Injectable Scaffolds and Their Applications in Regenerative Medicine,

in Chemistry of Materials

24

(5)

pp. 781-795

Full Text UEA Repository

(Article)

(Published)


Saeed, A. O., Newland, B., Pandit, A., Wang, W.

(2012)

The reverse of polymer degradation: in situ crosslinked gel formation through disulfide cleavage,

in Chemical Communications

48

(4)

pp. 585-587

Full Text UEA Repository

(Article)

(Published)


Dong, Y., Hassan, W., Zheng, Y., Saeed, A. O., Cao, H., Tai, H., Pandit, A., Wang, W.

(2012)

Thermoresponsive hyperbranched copolymer with multi acrylate functionality for in situ cross-linkable hyaluronic acid composite semi-IPN hydrogel,

in Journal of Materials Science-Materials in Medicine

23

(1)

pp. 25-35

Full Text UEA Repository

(Article)

(Published)


Dong, Y., Saeed, A. O., Hassan, W., Keigher, C., Zheng, Y., Tai, H., Pandit, A., Wang, W.

(2012)

“One-step” Preparation of Thiol-Ene Clickable PEG-Based Thermoresponsive Hyperbranched Copolymer for In Situ Crosslinking Hybrid Hydrogel,

in Macromolecular Rapid Communications

33

(2)

pp. 120-126

Full Text UEA Repository

(Article)

(Published)


Yaşayan, G., Saeed, A. O., Fernández-trillo, F., Allen, S., Davies, M. C., Jangher, A., Paul, A., Thurecht, K. J., King, S. M., Schweins, R., Griffiths, P. C., Magnusson, J. P., Alexander, C.

(2011)

Responsive hybrid block co-polymer conjugates of proteins–controlled architecture to modulate substrate specificity and solution behaviour,

in Polymer Chemistry

2

(7)

pp. 1567-1578

Full Text UEA Repository

(Article)

(Published)


Magnusson, J. P., Saeed, A. O., Fernández-Trillo, F., Alexander, C.

(2011)

Synthetic polymers for biopharmaceutical delivery,

in Polymer Chemistry

2

(1)

pp. 48-59

Full Text UEA Repository

(Article)

(Published)


Saeed, A. O., Magnusson, J. P., Moradi, E., Soliman, M., Wang, W., Stolnik, S., Thurecht, K. J., Howdle, S. M., Alexander, C.

(2011)

Modular Construction of Multifunctional Bioresponsive Cell-Targeted Nanoparticles for Gene Delivery,

in Bioconjugate Chemistry

22

(2)

pp. 156-168

Full Text UEA Repository

(Article)

(Published)


Heath, F., Saeed, A. O., Pennadam, S. S., Thurecht, K. J., Alexander, C.

(2010)

‘Isothermal’ phase transitions and supramolecular architecture changes in thermoresponsive polymers via acid-labile side-chains,

in Polymer Chemistry

1

(8)

pp. 1252-1262

Full Text UEA Repository

(Article)

(Published)


Dong, Y., Gunning, P., Cao, H., Mathew, A., Newland, B., Saeed, A. O., Magnusson, J. P., Alexander, C., Tai, H., Pandit, A., Wang, W.

(2010)

Dual stimuli responsive PEG based hyperbranched polymers,

in Polymer Chemistry

1

(6)

pp. 827-830

Full Text UEA Repository

(Article)

(Published)


Abulateefeh, S. R., Saeed, A. O., Aylott, J. W., Chan, W. C., Garnett, M. C., Saunders, B. R., Alexander, C.

(2009)

Facile synthesis of responsive nanoparticles with reversible, tunable and rapid thermal transitions from biocompatible constituents,

in Chemical Communications

(40)

pp. 6068-6070

Full Text UEA Repository

(Article)

(Published)


Saeed, A. O., Dey, S., Howdle, S. M., Thurecht, K. J., Alexander, C.

(2009)

One-pot controlled synthesis of biodegradable and biocompatible co-polymer micelles,

in Journal of Materials Chemistry

19

(26)

pp. 4529

Full Text UEA Repository

(Article)

(Published)


Magnusson, J. P., Khan, A., Pasparakis, G., Saeed, A. O., Wang, W., Alexander, C.

(2008)

Ion-Sensitive “Isothermal” Responsive Polymers Prepared in Water,

in Journal of the American Chemical Society

130

(33)

pp. 10852-10853

Full Text UEA Repository

(Article)

(Published)


Key Research Interests

My background and expertise span across several disciplines including polymer science (Chemistry), pharmaceutical formulation (Pharmacy), and tissue engineering and regenerative medicine (Biology and Medicine), in particular:

  • Design and synthesis of biodegradable, stimuli sensitive (temperature and pH) and functionalised polymers using controlled/living polymerisation techniques (ROP, RAFT and ATRP),
  • Fabrication of colloidal nano- and micro-carriers for targeted and controlled-release delivery of biopharmaceuticals, conventional drugs, biopolymers and therapeutic proteins.
  • Design and Synthesis of three-dimensional (3D) cell culture materials as injectable and implantable cell delivery systems.

 

My current research is focused on development of novel technology platforms for application in Drug Delivery and Tissue Engineering and Regenerative Medicine

 

  • Acellular 3D biomaterial matrices for use in cellular expansion (In vitro use)
  • Injectable hydrogels as cellular and therapeutic proteins delivery system (In vivo cellular based therapy)
  • 3D printing of complex cellular organisation and tissue-like pattern
  • Design, synthesis and characterisation of polymeric nanoparticulate drug delivery system
  • Targeted therapeutics for cancer treatment with “Smart” nanomaterial with controlled-release features

 

 

 

Teaching Interests

Modular Organiser - Introduction to Pharmacy Skills - Foundation year

Solid Dosage form and Microbiology - Industrial Pharmacy - MPharm

Pulmonary Delivery System - Immunology and infectious disease - MPharm

Research Project - MPharm