How blood and wealth can predict future disability

Published by  Communications

On 9th Dec 2020

Blood tests for ‘biomarkers’ such as cholesterol and inflammation could predict whether you will be disabled in five years – according to research from the University of East Anglia.

A new study shows how people’s biological health can predict disability and healthcare demand in five years’ time.

But the researchers also found that people on higher-incomes were more likely to seek GP appointments and outpatient treatments for their medical problems - with evidence of pro-rich inequity across all types of health service use.

Dr Apostolos Davillas from UEA’s Norwich Medical School, said: “We know that the poorest people in England miss out on more than a decade of good health compared with the richest.

“We wanted to find out more about the links between people’s social status and their future health - and see whether blood tests could predict future disability and use of health care services.”

The researchers looked at elevated bloodstream ‘biomarkers’ – these are the tell-tale markers linked to different diseases, and they are an objective measure of health.

Biomarkers can tell researchers a lot about what is going on in people’s bodies – even before symptoms of disease begin. Testing for ‘bad’ cholesterol in the bloodstream for example can show a risk of heart disease.

Dr Davillas’ previous research has shown how biomarkers for stress are linked with socioeconomic position and revealed some of the hidden mechanisms connecting social inequality to health.

The researchers studied blood biomarkers from 5,286 participants involved in Understanding Society, the UK Household Longitudinal Study.

They looked at things like cholesterol, liver and kidney function and inflammation – the body’s response to infections or chronic stress.

They also looked at measures of obesity, grip strength, resting heart rate, blood pressure, and lung function among the participants.

Dr Davillas said: “What we found is that underlying biomarker differences are linked with future disability – and that we could actually predict people’s level of disability in five years’ time, based on the biomarkers in their blood.

“We also found that people’s biological health is linked with future demand on healthcare services such as GP and outpatient consultations, as well as time spent in hospital.

“We tried to investigate the mechanism for why this happens and found that people with impaired biological health may develop disability in five years’ time – resulting in increased health care and social needs.”

But as a by-product of the analysis, the team found that people with higher incomes were more likely to seek the health care they need for their medical problems. This means that there is pro-rich inequity in health care use. 

“In a publicly funded health care system, pro-rich inequity in health care use may be because people on lower low-incomes are heavily time-constrained, due to harsher employment and living arrangements, and may be more constrained in seeking the health care they need,” Said Dr Davillas.

The team say their work has important policy implications, particularly for screening programmes and prevention strategies.

Dr Davillas said: “We found that the markers which matter most for disability progression are associated with lung function, grip strength, obesity, anaemia, stress-related hormones and liver function.

“Indicators such as blood pressure and cholesterol, which are the current focus of public health screening programs, are less useful as predictors of disability.

“The NHS England Health Check program mainly offers blood pressure, cholesterol tests and BMI measurements every five years to those aged 40-74.

“But our research shows that a broader set of blood-based biomarkers should be considered for public health screening programmes.

“This is increasingly feasible using dried blood spot sampling - drops of whole blood collected on filter paper from a finger prick - which offers a minimally invasive basis for carrying out a wide range of blood tests at low cost. 

“We also focused our study on people who were apparently healthy, so they wouldn’t normally be prioritised by the health care system. We hope our findings could lead to better policies for prevention strategies – which could potentially help the NHS save money.

“Moreover, our results show pro-rich inequity across all types of health service use.

“We hope our findings will help lead to policies to secure more equal health care opportunities across the UK.”

This research was co-authored by Dr Apostolos Davillas at UEA with Prof Stephen Pudney from the University of Sheffield.

Biomarkers, disability and health care demand’ is published in the December issue of the journal Economics & Human Biology.

Latest News

  News
25 Sep 2021

How rabbits help restore unique habitats for rare species

European wild rabbits are a ‘keystone species’ that hold together entire ecosystems – according to researchers at the University of East Anglia.

Read more >
  News
24 Sep 2021

Ageing the unageable: UEA researchers develop new way to age lobsters

Scientists at the University of East Anglia (UEA) have identified a way of determining the age of a lobster based on its DNA.

Read more >
  News
22 Sep 2021

New research reveals credit rating agencies responded too slowly to Covid-19

Sluggish response of credit rating agencies in assessing sovereign creditworthiness during the pandemic may have led to mispriced sovereign debt.

Read more >
  News
Robots in front of Productivity East building
22 Sep 2021

Productivity East launch

A new centre for skills, productivity and Engineering for the region launches this month

Read more >
Are you searching for something?
  News
Robots in front of Productivity East building
22 Sep 2021

Productivity East launch

A new centre for skills, productivity and Engineering for the region launches this month

Read more >
  News
Children and adults at ribbon cutting at IntoUniversity and UEA education centre opening event
17 Sep 2021

Thousands of local young people set to benefit as new education centre officially opens its doors

A new education centre was officially opened in West Earlham, one which is set to benefit thousands of young people from the most disadvantaged backgrounds in...

Read more >
  News
DNA
16 Sep 2021

Times Higher Education table puts UEA in the world’s top 100 for Life Sciences

The University of East Anglia (UEA) has maintained its place as a world top 100 university for Life Sciences degrees in the 2022 Times Higher Education (THE)...

Read more >
  News
16 Sep 2021

Vattenfall partnership to unlock benefits of offshore wind to the region

The University of East Anglia (UEA) and Vattenfall have announced a partnership that will place the East of England at the forefront of the offshore wind...

Read more >
  News
16 Sep 2021

How climate change could impact algae in the global ocean

Global warming is likely to cause abrupt changes to important algal communities because of shifting biodiversity ‘break point’ boundaries in the oceans –...

Read more >
  News
15 Sep 2021

UEA breakthrough could protect against breast cancer progression

Leading scientists have identified a possible link between antibiotic use and the speed of breast cancer growth in mice, and identified a type of immune cell...

Read more >