- Carding (Gut Microbiota and Immune Response)
- Watson (Epithelial Biology and Inflammatory Bowel Disease)
- Wileman (Virology and Epithelial Cell Culture)
- Hart (Epidemiology and Risk Factors for GI Disease)
- Schüller (E.coli/Epithelial Interactions)
- Hall (Bacteroides, Early Life Microbiota and NK Cells)
- Clinical Lecturer: Chan (Determinants of Response to Anti-TNF Therapy)
- Alexandre, Goode
Overall Aims of Research:
- To determine the host, microbial and environmental factors that contribute to a healthy GI-tract.
- To determine how disorders of host, microbial and environmental interactions lead to disease, particularly Inflammatory Bowel Disease, Microbial Gastroenteritis and Neoplasia.
- To give impact to the discoveries from the topics above by translating them into improved diagnostics and therapies.
The research strategy in Gastroenterology is integrated across the NRP with close cooperation between the Medical School, the NNUH and IFR. Professor Watson, Professor of Translational Medicine at UEA and Hon Consultant Gastroenterologist at NNUH and Professor Simon Carding Professor of Immunology at UEA lead gastroenterology research ad work closely together. Professor Carding is the Lead Investigator of the Institute Strategic Programme Grant (ISPG) "Gut Health and Food Safety" at the IFR. The programme of gastroenterology research at NMS is closely integrated into this ISPG which comprises of 13 research leaders, three of whom Carding, Watson and Wileman are UEA members of staff.
Professor Watson acts to coordinate the research of his clinical colleagues at NNUH (Tremelling, IBD clinical trials and genetics and Rushbrook, Genetics of sclerosis cholangitis), Clinical Senior Lecturers at UEA (Beales, clinical trials, Hart epidemiology of GI disease) and research leaders at IFR. Links between NNUH, UEA and IFR are further integrated as Professor Watson has his laboratory space in IFR.
Epidemiological research (Hart) is based on the European Prospective Investigation of Cancer (EPIC) database, which is a major study into the relationship between diet and disease including Inflammatory Bowel Disease. Data from EPIC taken forward within the UEA Gastroenterology research strategy as a source for hypothesis generation to be tested in the laboratory and by clinical trials.