Biography

I began my career at Harbin Medical University where I graduated with M.B. in Preventative Medicine, Master in Nutrition and a Lecturer for 4 years. During my PhD study at the Institute of Food Research (IFR), Norwich I developed a specific assay for a selenium dependent glutathione peroxidase (GPX4). After my PhD, I worked as Research Scientist and Senior Research Scientist at IFR. My research focused on chemopreventive activities of dietary phytochemicals. I moved to School of Medicine, UEA in March 2005 as a Lecturer.

 

Key Research Interests:

  • Mechanisms of phytochemicals in cancer prevention.
  • Interactions between isothiocyanates and selenium in selenoprotein gene expression.
  • Bioactivity of nanoencapsulated phytochemicals. 

Career History

  • Reader, University of East Anglia, August 2014-present
  • Senior Lecturer, University of East Anglia, August 2008-July 2014.
  • Lecturer, University of East Anglia, March 2005-2008.
  • Senior Scientist, Institute of Food Research, Norwich 2000-Feb 2005.
  • Research Scientist, Institute of Food Research, Norwich 1996-2000.
  • Lecturer, Harbin Medical University, China 1988-1992.
     

Academic Background

  • PhD, University of East Anglia, 1996.
  • M.Med, School of Public Health, Harbin Medical University, China 1987.
  • B.Med, Harbin Medical University, China 1983.

 

All Publications

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Wang, G., Chen, E., Liang, C., Liang, J., Gao, L., Chuai, M., Munsterberg, A., Bao, Y., Cao, L., Yang, X.

(2018)

Atg7-Mediated Autophagy Is Involved in the Neural Crest Cell Generation in Chick Embryo,

in Molecular Neurobiology

55

(4)

pp. 3523–3536

Full Text UEA Repository

(Article)

(Published)


Gao, L., Wang, G., Zhang, J., Li, S., Chuai, M., Bao, Y., Hocher, B., Yang, X.

(2018)

High salt‐induced excess reactive oxygen species production resulted in heart tube malformation during gastrulation,

in Journal of Cellular Physiology

Full Text UEA Repository

(Article)

(E-pub ahead of print)


Zhong, S., Zhang, S., Xing, H., Zhang, X., Wang, G., Bao, Y., Fu, J., Yang, X.

(2018)

Revealing histological and morphological features of female reproductive system in tree shrew (Tupaia belangeri),

in Zoomorphology

137

(1)

pp. 191–199

Full Text UEA Repository

(Article)

(Published)


Tian, S., Li, B., Lei, P., Yang, X., Zhang, X., Bao, Y., Shan, Y.

(2018)

Sulforaphane Improves Abnormal Lipid Metabolism via Both ERS-Dependent XBP1/ACC &SCD1 and ERS-Independent SREBP/FAS Pathways,

in Molecular Nutrition & Food Research

62

(6)

article no. 1700737

Full Text UEA Repository

(Article)

(Published)


Wang, G., Liang, J., Gao, L., Si, Z., Zhang, X., Liang, G., Yan, Y., Li, K., Cheng, X., Bao, Y., Chuai, M., Chen, L., Lu, D., Yang, X.

(2018)

Baicalin administration attenuates hyperglycemia-induced malformation of cardiovascular system,

in Cell Death & Disease

9

article no. 234

Full Text UEA Repository

(Article)

(Published)


Kong, W., Cui, Y., Fu, Y., Lei, Y., Ci, Y., Bao, Y., Zhao, S., Xie, L., Chang, Y., Zhao, S.

(2018)

The α1-adrenergic receptor is involved in hepcidin upregulation induced by adrenaline and norepinephrine via the STAT3 pathway,

in Journal of Cellular Biochemistry

Full Text UEA Repository

(Article)

(E-pub ahead of print)


Liu, P., Behray, M., Wang, Q., Wang, W., Zhou, Z., Chao, Y., Bao, Y.

(2018)

Anti-cancer activities of allyl isothiocyanate and its conjugated silicon quantum dots,

in Scientific Reports

8

article no. 1084

Full Text UEA Repository

(Article)

(Published)


He, C., Li, B., Huang, L., Liu, X., Tian, P., Bao, Y., Ren, M., Shan, Y.

(2017)

Gut microbiota bridges the inadequate consumption of fruits and bladder cancer,

in Oncotarget

Full Text UEA Repository

(Article)

(Published)


Liu, P., Atkinson, S. J., Akbareian, S., Zhou, Z., Munsterberg, A., Robinson, S., Bao, Y.

(2017)

Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma through inhibition of STAT3/HIF-1α/VEGF signalling,

in Scientific Reports

7

article no. 12651

Full Text UEA Repository

(Article)

(Published)


Wang, G., Chen, B., Wang, C., Zhang, J., Gao, L., Chuai, M., Bao, Y., Yang, X.

(2017)

Ethanol exposure leads to disorder of blood island formation in early chick embryo,

in Reproductive Toxicology

73

pp. 96-104

Full Text UEA Repository

(Article)

(Published)


Zhang, J., Wang, G., Liu, J., Gao, L., Liu, M., Wang, C., Chuai, M., Bao, Y., Li, G., Li, R., Zhang, Y., Yang, X.

(2017)

Gut microbiota-derived endotoxin enhanced the incidence of cardia bifida during cardiogenesis,

in Journal of Cellular Physiology

Full Text UEA Repository

(Article)

(E-pub ahead of print)


Dacosta, C., Bao, Y.

(2017)

The Role of MicroRNAs in the Chemopreventive Activity of Sulforaphane from Cruciferous Vegetables,

in Nutrients

9

(8)

article no. 902

Full Text UEA Repository

(Article)

(Published)


Davidson, R., Gardner, S., Jupp, O., Bullough, A., Butters, S., Watts, L., Donell, S., Traka, M., Saha, S., Mithen, R., Jeffers, M., Clegg, P., Bao, Y., Cassidy, A., Clark, I.

(2017)

Isothiocyanates are detected in human synovial fluid following broccoli consumption and can affect the tissues of the knee joint,

in Scientific Reports

7

article no. 3398

Full Text UEA Repository

(Article)

(Published)


Liu, H., Smith, A. J. O., Ball, S. S. R., Bao, Y., Bowater, R. P., Wang, N., Wormstone, I. M.

(2017)

Sulforaphane promotes ER stress, autophagy and cell death: implications for cataract surgery,

in Journal of Molecular Medicine

95

(5)

pp. 553–564

Full Text UEA Repository

(Article)

(Published)


Wang, Y., Zhou, Z., Wang, W., Liu, M., Bao, Y.

(2017)

Differential effects of sulforaphane in regulation of angiogenesis in a co-culture model of endothelial cells and pericytes,

in Oncology Reports

37

(5)

pp. 2905-2912

Full Text UEA Repository

(Article)

(Published)


Gao, L., Li, S., Zhang, J., Liang, C., Chen, E., Zhang, S., Chuai, M., Bao, Y., Wang, G., Yang, X.

(2016)

Excess imidacloprid exposure causes the heart tube malformation of chick embryos,

in Journal of Agricultural and Food Chemistry

64

(47)

pp. 9078–9088

Full Text UEA Repository

(Article)

(Published)


Zhang, H. Q., Chen, S. Y., Wang, A. S., Yao, A. J., Fu, J. F., Zhao, J. S., Chen, F., Zhou, Z. Q., Zhang, X. H., Shan, Y. J., Bao, Y. P.

(2016)

Sulforaphane induces adipocyte browning and promotes glucose and lipid utilization,

in Molecular Nutrition & Food Research

60

(10)

pp. 2185–2197

Full Text UEA Repository

(Article)

(Published)


Davidson, R., Jupp, O., Bao, Y., Macgregor, A., Donell, S., Cassidy, A., Clark, I.

(2016)

Can sulforaphane prevent the onset or slow the progression of osteoarthritis?,

in Nutrition Bulletin

41

(2)

pp. 175-179

Full Text UEA Repository

(Article)

(Published)


Lei, X. G., Zhu, J., Chen, W., Bao, Y., Ho, Y., Reddi, A. R., Holmgren, A., Arnér, E. S.

(2016)

Paradoxical roles of antioxidant enzymes: Basic mechanisms and health implications,

in Physiological Reviews

96

(1)

pp. 307-364

Full Text UEA Repository

(Article)

(Published)


Ma, Y., Gao, W., Wu, K., Bao, Y.

(2015)

Flavonoid intake and the risk of age-related cataract in China’s Heilongjiang Province,

in Food & Nutrition Research

59

article no. 29564

Full Text UEA Repository

(Article)

(Published)


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Key Research Interests

  • Mechanisms of phytochemicals in cancer prevention.
  • Interactions between isothiocyanates and selenium in selenoprotein gene expression.
  • Bioactivity of nanoencapsulated phytochemicals. 

 

 

Selected Recent Publications:

  1. Liu P, Behray M, Wang Q, Wang W, Zhou Z, Chao Y, Bao Y. Anti-cancer activities of allyl isothiocyanate and its conjugated silicon quantum dots. Sci Rep. 2018; 8:1084. doi: 10.1038/s41598-018-19353-7.

  2. Tian S, Li B, Lei P, Yang X, Zhang X, Bao Y, Shan Y. Sulforaphane regulates abnormal lipid metabolism via both ERS-dependent XBP1/ACC & SCD1 and ERS-independent SREBP/FAS pathways. Mol Nutr Food Res. 2018 Jan 30. doi: 10.1002/mnfr.201700737. [Epub ahead of print].

  3. Liu P, Atkinson SJ, Akbareian SE, Zhou Z, Munsterberg A, Robinson, SD, Bao Y. Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma through inhibition of STAT3/HIF1-α/VEGF signalling. Sci Rep. 2017; 7(1):12651. doi: 10.1038/s41598-017-12855-w.

  4. Zhang HQ, Chen SY, Wang AS, Yao AJ, Fu JF, Zhao JS, Chen F, Zou ZQ, Zhang XH, Shan YJ, Bao YP. Sulforaphane induces adipocyte browning and promotes glucose and lipid utilization. Mol Nutr Food Res. 2016; 60(10):2185-2197. doi: 10.1002/mnfr.201500915.

 

Teaching Interests

My teaching is mainly focussed on the MB/BS medical degree course. My teaching interests are in providing medical students with an understanding of the basic nutritional requirements and the diet and prevention of chronic diseases including cancer, CVD and diabetes.  Another interest is the teaching of lab-based research projects, nutritional clinical skills and dietary assessment.

External Activities and Indicators of Esteem

  • Visiting Professor (PhD supervisor), Harbin Medical University, China (2003).
  • Editorial Board: Biophysics Reports; Food Chemistry; Journal of Biochemical and Pharmacological Research

Professional Activities

  • Fellow of the the Royal Society of Chemistry (FRSC) 2009.
  • Grant reviewer for BBSRC, MRC, CRUK, and foreign funding bodies including NSFC.

Key Responsibilities

 SSS theme lead for Nutrition

Administrative Posts

  • SSS theme lead for Nutrition.
  • Co-theme Lead for Nutrition teaching in MBBS.