Career History

  • January 2015-present, Head of Norwich Medical School
  • 2004-2009, Regius Professor of Medicine, University of Aberdeen

  • 1996-2004, British Heart Foundation Sir Thomas Lewis Chair of Cardiology, University of Wales College of Medicine

  • 1994, promoted to Professor of Medicine, University of Queensland and Deputy Director of Medicine, whilst continuing as Director of Cardiology, Royal Brisbane Hospital

  • 1991, appointed Clinical Director of Cardiology, Royal Brisbane Hospital and Senior Lecturer in Cardiology, University of Queensland

  • 1988-1991, Consultant Cardiologist, Canterbury, New Zealand
  • 1991, MD on abnormal vascular control mechanisms in Hypertrophic Cardiomyopathy and their relationship to sudden cardiac death

  • Trained in Cardiology, Edinburgh, Hammersmith and St George’s Hospitals, London

  • Senior House Officer posts at Hammersmith and Brompton Hospitals as well as National Hospital for Nervous Diseases, Queen Square, London

  • House Officer posts at Westminster Hospital

  • Pre-clinical studies at King’s College, London and clinical studies at Westminster Medical School, qualifying in 1980; awarded the University of London Gold Medal

 

Professional Qualifications:

  • MB BS (Hons), London University 1980 and University Gold Medallist
  • MD University of London, 1991
  • MRCP (UK), 1983
  • FRACP, 1987
  • FRCP, London 1998, Edinburgh 2009
  • Fellowship of the American College of Cardiology, 1993
  • Fellowship of the European Society of Cardiology, 1998
  • Fellowship of the Academy of Medical Sciences, 2008

All Publications

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Ormerod, J. O., Evans, J. D., Contractor, H., Beretta, M., Arif, S., Fernandez, B. O., Feelisch, M., Mayer, B., Kharbanda, R. K., Frenneaux, M. P., Ashrafian, H.

(2017)

Human Second Window Pre-Conditioning and Post-Conditioning by Nitrite Is Influenced by a Common Polymorphism in Mitochondrial Aldehyde Dehydrogenase

Full Text UEA Repository

(Article)


Halliday, B., Gulati, A., Ali, A., Guha, K., Newsome, S. J., Arzanauskaite, M., Vassiliou, V. S., Lota, A. S., Izgi, C., Tayal, U., Khalique, Z., Stirrat, C., Auger, D., Pareek, N., Ismail, T. F., Rosen, S. D., Vazir, A., Alpendurada, F., Gregson, J., Frenneaux, M. P., Cowie, M. R., Cleland, J. G. F., Cook, S. A., Pennell, D. J., Prasad, S. K.

(2017)

Association Between Mid-Wall Late Gadolinium Enhancement and Sudden Cardiac Death in Patients with Dilated Cardiomyopathy and Mild and Moderate Left Ventricular Systolic Dysfunction

Full Text UEA Repository

(Article)


Tseng, C., Noordali, H., Sani, M., Madhani, M., Grant, D. M., Frenneaux, M. P., Zanda, M., Greig, I. R.

(2017)

Development of Fluorinated Analogues of Perhexiline with Improved Pharmacokinetic Properties and Retained Efficacy

Full Text UEA Repository

(Article)


Loudon, B. L., Noordali, H., Gollop, N. D., Frenneaux, M. P., Madhani, M.

(2016)

Present and future pharmacotherapeutic agents in heart failure: an evolving paradigm

Full Text UEA Repository

(Article)


Pal, N., Sivaswamy, N., Mahmod, M., Yavari, A., Rudd, A., Singh, S., Dawson, D. K., Francis, J. M., Dwight, J. S., Watkins, H., Neubauer, S., Frenneaux, M., Ashrafian, H.

(2016)

Response to Letter Regarding Article, “The Effect of Selective Heart Rate Slowing in Heart Failure With Preserved Ejection Fraction”

Full Text

(Comment/debate)


Leyva, F., Umar, F., Taylor, R. J., Steeds, R. P., Frenneaux, M. P.

(2016)

The clinical outcome of cardiac resynchronization therapy in post-surgical valvular cardiomyopathy

Full Text UEA Repository

(Article)


Bowater, S., Weaver, R., Beadle, R., Frenneaux, M., Marshall, J., Clift, P.

(2016)

Assessment of the Physiological Adaptations to Chronic Hypoxemia in Eisenmenger Syndrome

Full Text UEA Repository

(Article)


Parasuraman, S., Walker, S., Loudon, B. L., Gollop, N. D., Wilson, A. M., Lowery, C., Frenneaux, M. P.

(2016)

Assessment of pulmonary artery pressure by echocardiography—A comprehensive review

Full Text UEA Repository

(Article)


Ormerod, J. O. M., Frenneaux, M. P., Sherrid, M. V.

(2016)

Myocardial energy depletion and dynamic systolic dysfunction in hypertrophic cardiomyopathy

Full Text UEA Repository

(Article)


Raphael, C. E., Cooper, R., Parker, K. H., Collinson, J., Vassiliou, V., Pennell, D. J., de Silva, R., Hsu, L. Y., Greve, A. M., Nijjer, S., Broyd, C., Ali, A., Keegan, J., Francis, D. P., Davies, J. E., Hughes, A. D., Arai, A., Frenneaux, M., Stables, R. H., Di Mario, C., Prasad, S. K.

(2016)

Mechanisms of Myocardial Ischemia in Hypertrophic Cardiomyopathy : Insights From Wave Intensity Analysis and Magnetic Resonance

Full Text UEA Repository

(Article)


Schwarz, K., Singh, S., Parasuraman, S. K., Bruce, M., Shepstone, L., Feelisch, M., Minnion, M., Ahmad, S., Horowitz, J., Dawson, D. K., Frenneaux, M. P.

(2016)

A randomized double-blind placebo-controlled crossover trial of sodium nitrate in patients with stable angina INAS

Full Text UEA Repository

(Article)


Raphael, C. E., Keegan, J., Parker, K. H., Simpson, R., Collinson, J., Vassiliou, V., Wage, R., Drivas, P., Strain, S., Cooper, R., de Silva, R., Stables, R. H., Di Mario, C., Frenneaux, M., Pennell, D. J., Davies, J. E., Hughes, A. D., Firmin, D., Prasad, S. K.

(2016)

Feasibility of cardiovascular magnetic resonance derived coronary wave intensity analysis

Full Text UEA Repository

(Article)


Beadle, R. M., Williams, L. K., Kuehl, M., Bowater, S., Abozguia, K., Leyva, F., Yousef, Z., Wagenmakers, A. J., Thies, F., Horowitz, J., Frenneaux, M. P.

(2015)

Improvement in Cardiac Energetics by Perhexiline in Heart Failure Due to Dilated Cardiomyopathy

Full Text UEA Repository

(Article)


Senanayake, E. L., Howell, N. J., Ranasinghe, A. M., Drury, N. E., Freemantle, N., Frenneaux, M., Oelofse, T., Green, D., Wilson, I. C., Rooney, S. J., Mascaro, J., Graham, T. R., Bhudia, S., Lewis, M., Pagano, D.

(2015)

Multicentre double-blind randomized controlled trial of perhexiline as a metabolic modulator to augment myocardial protection in patients with left ventricular hypertrophy undergoing cardiac surgery

Full Text UEA Repository

(Article)


Dawson, D. K., Neil, C. J., Henning, A., Cameron, D., Jagpal, B., Bruce, M., Horowitz, J., Frenneaux, M. P.

(2015)

Tako-Tsubo Cardiomyopathy: A Heart Stressed Out of Energy?

Full Text UEA Repository

(Article)


Drury, N. E., Howell, N. J., Calvert, M. J., Weber, R. J. M., Senanayake, E. L., Lewis, M. E., Hyde, J. A. J., Green, D. H., Mascaro, J. G., Wilson, I. C., Graham, T. R., Rooney, S. J., Viant, M. R., Freemantle, N., Frenneaux, M. P., Pagano, D.

(2015)

The effect of perhexiline on myocardial protection during coronary artery surgery: a two-centre, randomized, double-blind, placebo-controlled trial

Full Text UEA Repository

(Article)


Cameron, D., Higgins, D. M., Stehning, C., Kouwenhoven, M., Bouhrara, M., Frenneaux, M. P., Dawson, D. K., Redpath, T. W.

(2015)

Selection of magnetization catalyzation and readout methods for modified Look–Locker inversion recovery: A T1 mapping primer

Full Text UEA Repository

(Article)


Alhous, M. H. A., Small, G. R., Hannah, A., Hillis, G. S., Frenneaux, M., Broadhurst, P. A.

(2015)

Right ventricular septal pacing as alternative for failed left ventricular lead implantation in cardiac resynchronization therapy candidates

Full Text UEA Repository

(Article)


Ormerod, J. O. M., Arif, S., Mukadam, M., Evans, J. D. W., Beadle, R., Fernandez, B. O., Bonser, R. S., Feelisch, M., Madhani, M., Frenneaux, M. P.

(2015)

Short-Term Intravenous Sodium Nitrite Infusion Improves Cardiac and Pulmonary Hemodynamics in Heart Failure Patients

Full Text UEA Repository

(Article)


Beadle, R. M., Frenneaux, M. P.

(2015)

Reply: Perhexiline, cardiac energetics, and heart failure: lessons from the first law of thermodynamics

Full Text

(Letter)


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Key Research Interests

I am a translational integrated cardiovascular physiologist. My major areas of interest are:

  • cardiac energetic impairment and the role of novel therapies targeting this energetic impairment in heart muscle diseases

  • ventriculo-ventricular and ventriculo-vascular interaction as well as their role in cardiac dysfunction in the failing heart

  • the epidemiology, pathophysiology and therapy of Heart Failure with Preserved Left Ventricular Ejection Fraction

Professional Activities

  • Member of the BHF Chair and Programme Grants Committee, Academy of Medical Sciences Starter Grants Panel (and previously, sectional committee for award of Fellowships)

  • Previous member of the MRC Population and Systems Medicine Board and current member of the MRC Oversight Group of the UK Dementia Platform

  • Medical Schools Council representative on the Clinical Staff Advisory Group of the University and College Employers Association

  • Cardiovascular Editor, Journal of Physiology

Administrative Posts

  • Head of School, 2015-present
  • Member of the BHF Chair and Programme Grants Committee, Academy of Medical Sciences Starter Grants Panel (and previously, sectional committee for award of Fellowships)

  • Previous member of the MRC Population and Systems Medicine Board and current member of the MRC Oversight Group of the UK Dementia Platform

  • Medical Schools Council representative on the Clinical Staff Advisory Group of the University and College Employers Association

  • Cardiovascular Editor, Journal of Physiology