Career History

  • Operations Manager, Norwich Clinical Trials Unit (April 2015 to Current)
  • Clinical Trials Project Manager/QA Lead, Norwich Clinical Trials Unit (March 2015 to April 2015)
  • Senior Researcher, Research in Real Life Ltd and Optimum Patient Care Ltd (November 2007 to February 2015)
  • Research Associate and UK CF Database Fellow, Institute of Health, University of East Anglia, 2004 to October 2007.
  • UK CF Database Fellow, Maternal & Child Health Sciences, University of Dundee, 2001 to 2004
  • Postdoctoral Research Fellow and Clinical Trials Coordinator, Asthma & Allergy Research Group, University of Dundee. 2000 to 2001
  • Research Assistant and Clinical Trials Coordinator, Asthma & Allergy Research Group, University of Dundee. 1997 to 2000
  • Research Assistant on project entitled ‘Predicting Drug Absorption From the Gastrointestinal Tract’, University of Manchester. 1993 to 1997

Academic Background

  • BSc(Hons) in Biomedical Technology, Sheffield Hallam University, 1993
  • PhD entitled ‘Regulation of Epithelial Tight Junctions’, Schools of Medicine and Pharmacy, University of Manchester, 2000.

Highlighted Publications

See All

Price, D., Musgrave, S., Shepstone, L., Hillier, E., Sims, E., Gilbert, R., Juniper, E., Ayres, J., Kemp, L., Blyth, A., Wilson, E., Wolfe, S., Freeman, D., Mugford, M., Murdoch, J., Harvey, I.

(2011)

Leukotriene antagonists as first-line or add-on asthma controller therapy,

in New England Journal of Medicine

364.

pp. 1695-1707

Full Text UEA Repository

(Article)

(Published)


Wilson, E., Price, D., Musgrave, S., Sims, E., Shepstone, L., Murdoch, J., Mugford, M., Blyth, A., Juniper, E., Ayres, J., Wolfe, S., Freeman, D., Gilbert, R., Hillyer, E., Harvey, I.

(2010)

The cost effectiveness of leukotriene receptor antagonists versus long acting beta-2 agonists as add-on therapy to inhaled corticosteroids for asthma: a pragmatic trial,

in Pharmacoeconomics

28.

pp. 597-608

Full Text UEA Repository

(Article)

(Published)


Wilson, E., Sims, E., Musgrave, S., Shepstone, L., Blyth, A., Murdoch, J., Mugford, M., Juniper, E., Ayres, J., Wolfe, S., Freeman, D., Gilbert, R., Harvey, I., Hillyer, E., Price, D.

(2010)

The cost effectiveness of leukotriene receptor antagonists versus inhaled corticosteroids for initial asthma controller therapy: a pragmatic trial,

in Pharmacoeconomics

28.

pp. 585-595

Full Text UEA Repository

(Article)

(Published)


Sims, E., Clark, A., McCormick, J., Metha, G., Connett, G., Metha, A.

(2007)

Cystic fibrosis diagnosed after two months of age leads to worse outcomes and requires more therapy,

in Pediatrics

119.

pp. 19-28

Full Text UEA Repository

(Article)

(Published)


Sims, E., Mugford, M., Clark, A., Aitken, D., McCormick, J., Mehta, G., Mehta, A.

(2007)

Economic implications of newborn screening for cystic fibrosis: a cost of illness retrospective cohort study,

in The Lancet

369.

pp. 1187-1195

Full Text UEA Repository

(Article)

(Published)


All Publications

See Highlights
<- Page 1 of 3 ->

Hammond, S. P., Cross, J. L., Shepstone, L., Backhouse, T., Henderson, C., Poland, F., Sims, E., MacLullich, A., Penhale, B., Howard, R., Lambert, N., Varley, A., Smith, T. O., Sahota, O., Donell, S., Patel, M., Ballard, C., Young, J., Knapp, M., Jackson, S., Waring, J., Leavey, N., Howard, G., Fox, C.

(2017)

PERFECTED enhanced recovery (PERFECT-ER) care versus standard acute care for patients admitted to acute settings with hip fracture identified as experiencing confusion: study protocol for a feasibility cluster randomized controlled trial,

in Trials

18

article no. 583

Full Text UEA Repository

(Article)

(Published)


Chrystyn, H., Price, D. B., Molimard, M., Haughney, J., Bosnic-Anticevich, S., Lavorini, F., Efthimiou, J., Shan, D., Sims, E., Burden, A., Hutton, C., Roche, N.

(2016)

Comparison of serious inhaler technique errors made by device-naïve patients using three different dry powder inhalers: a randomised, crossover, open-label study,

in BMC Pulmonary Medicine

16

article no. 12

Full Text UEA Repository

(Article)

(Published)


Jones, R. C. M., Price, D., Ryan, D., Sims, E. J., von Ziegenweidt, J., Mascarenhas, L., Burden, A., Halpin, D. M. G., Winter, R., Hill, S., Kearney, M., Holton, K., Moger, A., Freeman, D., Chisholm, A., Bateman, E. D.

(2014)

Opportunities to diagnose chronic obstructive pulmonary disease in routine care in the UK: a retrospective study of a clinical cohort,

in The Lancet Respiratory Medicine

2

(4)

pp. 267-276

Full Text UEA Repository

(Article)

(Published)


Price, D., Musgrave, S., Shepstone, L., Hillier, E., Sims, E., Gilbert, R., Juniper, E., Ayres, J., Kemp, L., Blyth, A., Wilson, E., Wolfe, S., Freeman, D., Mugford, M., Murdoch, J., Harvey, I.

(2011)

Leukotriene antagonists as first-line or add-on asthma controller therapy,

in New England Journal of Medicine

364

(18)

pp. 1695-1707

Full Text UEA Repository

(Article)

(Published)


Price, D., Musgrave, S., Wilson, E., Sims, E., Shepstone, L., Blyth, A., Murdoch, J., Mugford, M., Juniper, E., Ayres, J., Wolfe, S., Freeman, D., Lipp, A., Gilbert, R., Harvey, I.

(2011)

A pragmatic single-blind randomised controlled trial and economic evaluation of the use of leukotriene receptor antagonists in primary care at steps 2 and 3 of the national asthma guidelines (ELEVATE study),

in Health Technology Assessment

15

(21)

pp. 1-132

Full Text UEA Repository

(Article)

(Published)


Wilson, E., Price, D., Musgrave, S., Sims, E., Shepstone, L., Murdoch, J., Mugford, M., Blyth, A., Juniper, E., Ayres, J., Wolfe, S., Freeman, D., Gilbert, R., Hillyer, E., Harvey, I.

(2010)

The cost effectiveness of leukotriene receptor antagonists versus long acting beta-2 agonists as add-on therapy to inhaled corticosteroids for asthma: a pragmatic trial,

in Pharmacoeconomics

28

(7)

pp. 597-608

Full Text UEA Repository

(Article)

(Published)


Wilson, E., Sims, E., Musgrave, S., Shepstone, L., Blyth, A., Murdoch, J., Mugford, M., Juniper, E., Ayres, J., Wolfe, S., Freeman, D., Gilbert, R., Harvey, I., Hillyer, E., Price, D.

(2010)

The cost effectiveness of leukotriene receptor antagonists versus inhaled corticosteroids for initial asthma controller therapy: a pragmatic trial,

in Pharmacoeconomics

28

(7)

pp. 585-595

Full Text UEA Repository

(Article)

(Published)


Sims, E., Clark, A., McCormick, J., Metha, G., Connett, G., Metha, A.

(2007)

Cystic fibrosis diagnosed after two months of age leads to worse outcomes and requires more therapy,

in Pediatrics

119

(1)

pp. 19-28

Full Text UEA Repository

(Article)

(Published)


Sims, E., Mugford, M., Clark, A., Aitken, D., McCormick, J., Mehta, G., Mehta, A.

(2007)

Economic implications of newborn screening for cystic fibrosis: a cost of illness retrospective cohort study,

in The Lancet

369

(9568)

pp. 1187-1195

Full Text UEA Repository

(Article)

(Published)


McCormick, J., Sims, E., Mehta, A.

(2006)

A delayed diagnosis of females with respiratory presentation of cystic fibrosis did not segregate with poorer clinical outcome,

in Journal of Clinical Epidemiology

59

(3)

pp. 315-322

UEA Repository

(Article)

(Published)


Lipworth, B., Sims, E., Das, S., Buck, H., Paterson, M.

(2005)

Dose-response comparison of budesonide dry powder inhalers using adenosine monophosphate bronchial challenge,

in Annals of Allergy, Asthma & Immunology

94

(6)

pp. 675-681

UEA Repository

(Article)

(Published)


Lipworth, B., Sims, E., Das, S., Morice, A., O'Connor, B.

(2005)

Bronchoprotection with formoterol via dry powder and metered-dose inhalers in patients with asthma,

in Annals of Allergy, Asthma & Immunology

95

(3)

pp. 283-290

UEA Repository

(Article)

(Published)


Lipworth, B., Sims, E., Taylor, K., Cockburn, W., Fishman, R.

(2005)

Dose-response to albutamol via a novel palm sized nebuliser (Aerodose Inhaler), conventional nebuliser (Pari LC Plus) and metered dose inhaler (Ventolin Evohaler) in moderate to severe asthmatics,

in British Journal of Clinical Pharmacology

59

(1)

pp. 5-13

UEA Repository

(Article)

(Published)


McCormick, J., Ogston, S., Sims, E., Mehta, A.

(2005)

Asians with cystic fibrosis in the UK have worse disease outcomes than clinic matched white homozygous delta F508 controls,

in Journal of Cystic Fibrosis

4

(1)

pp. 53-58

UEA Repository

(Article)

(Published)


McCormick, J., Sims, E., Green, M., Mehta, G., Culross, F., Mehta, A.

(2005)

Comparative analysis of Cystic Fibrosis Registry data from the UK with USA, France and Australasia,

in Journal of Cystic Fibrosis

4

(2)

pp. 115-122

UEA Repository

(Article)

(Published)


Sims, E., Green, M., Mehta, A.

(2005)

Decreased Lung Function in Female but not Male Subjects With Established Cystic Fibrosis-Related Diabetes,

in Diabetes Care

28

(7)

pp. 1581-1587

UEA Repository

(Article)

(Published)


Sims, E., McCormick, J., Mehta, G., Mehta, A.

(2005)

Newborn screening for cystic fibrosis is associated with reduced treatment intensity,

in Pediatrics

147

(3)

pp. 306-311

UEA Repository

(Article)

(Published)


Mehta, G., Sims, E., Culross, F., McCormick, J., Mehta, A.

(2004)

Potential benefits of the UK Cystic Fibrosis Database,

in Royal Society of Medicine

97

(Suppl 44)

pp. 60-71

UEA Repository

(Article)

(Published)


Sims, E., Lipworth, B.

(2004)

Concomitant occasional use of salbutamol influences bronchoprotective responsiveness afforded by formoterol in patients with the glycine-16 genotype,

in European Journal of Clinical Pharmacology

59

(11)

pp. 791-795

UEA Repository

(Article)

(Published)


Lee, D., Robb, F., Sims, E., Currie, G., McFarlane, L., Lipworth, B.

(2003)

Systemic bioactivity of intranasal triamcinolone and mometasone in perennial allergic rhinitis,

in British Journal of Clinical Pharmacology

55

(3)

pp. 310-313

UEA Repository

(Article)

(Published)


<- Page 1 of 3 ->

Key Research Interests

My research interests are:

  1. Efficient trial delivery methodology with specific interest in research delivery methods in primary care, care home and transitional care environments
  2. Health policy related to diagnosis and management of chronic disease

Research Group Membership

Population Health, Health Economics, BioMed

Teaching Interests

I deliver the 'Research Design Service and Clinical Trial Units and the Role of the PI’ lecture for the Foundations of Clinical Research module of the UEA MSc in Clinical Research

 

External Activities and Indicators of Esteem

Provide mentoring support on QA and Operational issues for CTUs seeking Provisional or Full Accreditation

Professional Activities

  • Norwich Clinical Trials Unit representative on NNUH/UEA Joint Research Office Research Governance Committee (February 2018 onwards)

  • Norwich Clinical Trials Unit representative on UKCRC CTU QA Forum (March 2015 onwards)

  • Norwich Clinical Trials Unit lead representative on NNUH/UEA Joint Research Office Research Governance Operations Group (March 2015 onwards)

  • Norwich Clinical Trials Unit lead representative on NNUH/UEA Joint Research Office Operations Group (March 2015 onwards)
  • RA Representative on IOH Executive Committee (October 2006 to October 2007)