Professional Qualifications and professional memberships
- PhD in Chemical and Biological Sciences for Health, Faculty of Pharmacy, University Montpellier 1, France
- MSc in Biological and Medical Sciences, Faculty of Pharmacy, University Bordeaux 2, France
- BSc in Molecular and Cellular Biochemistry/Pharmacology, Faculty of Medicine, University Bordeaux 2, France
- Member of The Groupe Polyphenols
- Member of the Biochemical Society
Research Fellow, University of East Anglia, UK (2011-present) Post-Doctoral Research Fellow, University of Reading, UK (2008-2011) (BBSRC Fellowship)Post-Doctoral Research Fellow, University of Reading, UK (2005-2008) (MRC Fellowship)
<- Page 1 of 4 ->
Inhibition of PP2A by hesperetin contributes to Akt and ERK1/2 activation in primary cortical neurons,
in Archives of Biochemistry and Biophysics
pp. 14-21Full Text UEA Repository
(E-pub ahead of print)
Impact of Flavonoids on Cellular and Molecular Mechanisms Underlying Age-Related Cognitive Decline and Neurodegeneration,
in Current Nutrition ReportsFull Text UEA Repository
Poor cognitive ageing: Vulnerabilities, mechanisms and the impact of nutritional interventions,
in Ageing Research Reviews
pp. 40–55Full Text UEA Repository
N-3 fatty acids combined with flavan-3-ols prevent steatosis and liver injury in a murine model of NAFLD,
in Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
pp. 69-78Full Text UEA Repository
Nutrition for the ageing brain: towards evidence for an optimal diet,
in Ageing Research Reviews
pp. 222–240Full Text
The effect of dietary fish oil on weight gain and insulin sensitivity is dependent on APOE genotype in humanized targeted replacement mice,
in The FASEB Journal
pp. 989-997Full Text UEA Repository
Polyphenols and brain health,
article no. A202Full Text UEA Repository
Neuroprotective Effects of Polyphenols in Aging and Age-Related Neurological Disorders,
in Neuroprotective Effects of Phytochemicals in Neurological Disorders.
ISBN 978-1-119-15514-0Full Text
High-flavonoid intake induces cognitive improvements linked to changes in serum brain-derived neurotrophic factor: Two randomised, controlled trials,
in Nutrition and Healthy Aging
pp. 81-93Full Text UEA Repository
Differential effects of EPA vs. DHA on postprandial vascular function and the plasma oxylipin profile in men,
in The Journal of Lipid Research
pp. 1720-1727Full Text UEA Repository
Neuroprotective Effects Associated with Wine and Its Phenolic Constituents,
in Wine Safety, Consumer Preference, and Human Health.
Springer International Publishing
ISBN 978-3-319-24512-6Full Text UEA Repository
Polyphenols and non-alcoholic fatty liver disease: impact and mechanisms: impact and mechanisms,
in Proceedings of the Nutrition Society.
ISBN 0029-6651Full Text
A transgenic Camelina sativa seed oil effectively replaces fish oil as a dietary source of eicosapentaenoic acid in mice,
in Journal of Nutrition
pp. 227-235Full Text UEA Repository
Low-grade inflammation, diet composition and health: Current research evidence and its translation,
in British Journal of Nutrition
pp. 999-1012Full Text UEA Repository
Neuroinflammatory processes in cognitive disorders: Is there a role for flavonoids and n-3 polyunsaturated fatty acids in counteracting their detrimental effects?,
in Neurochemistry International
pp. 63-74Full Text UEA Repository
Anthocyanins do not influence long-chain n-3 fatty acid status: Studies in cells, rodents and humans,
in Journal of Nutritional Biochemistry
pp. 211-218Full Text UEA Repository
Do anthocyanins in purple tomatoes reduce the risk of cardiovascular disease?,
in Proceedings of the Nutrition Society
pp. E85Full Text UEA Repository
Dietary Polyphenols and Their Effects on Cell Biochemistry and Pathophysiology 2014,
in Oxidative Medicine and Cellular Longevity
article no. 782424Full Text
The neurotoxicity of 5-S-cysteinyldopamine is mediated by the early activation of ERK1/2 followed by the subsequent activation of ASK-1/JNK1/2 pro-apoptotic signalling,
in Biochemical Journal
pp. 41-52Full Text UEA Repository
Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update,
in Archives of Toxicology
pp. 1803-1853Full Text UEA Repository
<- Page 1 of 4 ->
Key Research Interests
- Neurodegenerative disorders
- Memory, learning and neuro-cognitive performances
- Molecular mechanisms
- Association between the APOE4 genotype and chronic disease risk
My research interest is to develop novel dietary or therapeutic strategies to delay brain ageing, cognitive decline and cardiovascular disease, including stroke and vascular dementia and involves the fields of oxidative stress, free radical biochemistry, neurodegeneration and the health effects of dietary polyphenols, such as flavonoids. Concurrently, my major research interests centre on two functionally associated fields of biomedical sciences: 1) The elucidation of cellular and molecular mechanisms underlying the toxicity exerted by endogenously formed compounds, as well as exogenous agents, believed to be involved in various degenerative diseases; 2) The cellular and molecular principles involved in the protective effects evoked by potentially beneficial natural compounds.
Using a variety of experimental models including primary brain cell culture, age-related cognitive decline rodents and human intervention trials, my initial work has provided further insights into the potential for phytochemicals and their in vivo metabolites to promote human vascular function, decrease (neuro)inflammation, enhance memory, learning and neuro-cognitive performances and to slow the progression of Alzheimer’s and Parkinson’s disease pathophysiology. This work has led to substantial knowledge of potential mechanisms of action of phytochemicals based on their modulation of intracellular signalling pathways. In particular, my major contribution has been to show that phytochemicals exert such diverse biological effects through their modulation of intracellular signalling pathways (MAP kinases, PI3 kinase/Akt and Keap-1/Nrf2). My recent interests concern the investigation of the aetiological basis of APOEgenotype-disease associations, and the impact of this common genotype on responsiveness to dietary changes. This work is very much at the translational end of the research spectrum and aligned with the current move towards a more personalised approach to disease prevention and therapeutics.
Selected recent publications
Vauzour, D. (2012) Dietary Polyphenols as Modulators of Brain Functions: Biological Actions and Molecular Mechanisms Underpinning Their Beneficial Effects. Oxid Med Cell Longev. doi:10.1155/2012/914273
Rendeiro, C, Vauzour, D, Kean, RJ, Butler, LT, Rattray, M, Spencer, JPE and Williams, CM (2012) Blueberry supplementation induces spatial memory improvements and region-specific regulation of hippocampal BDNF mRNA expression in young rats. Psychopharmacology. 223(3). Pp 319-330
Spencer, JPE, Vafeiadou, K, Williams, RJ and Vauzour, D (2012) Neuroinflammation: Modulation by flavonoids and mechanisms of action. Molecular Aspects of Medicine, 33 (1). pp. 83-97.
Spilsbury, A, Vauzour, D, Spencer, JPE and Rattray, M (2012) Regulation of NF-κB activity in astrocytes: Effects of flavonoids at dietary-relevant concentrations. Biochemical and Biophysical Research Communications. 418(3). pp. 578-583
Vauzour, D and Minihane, A-M (2012) Neuroinflammation and the APOε genotype: Implications for Alzheimer's disease and modulation by dietary flavonoids and n-3 polyunsaturated fatty acids. Nutrition and Aging, 1 (1). pp. 41-53.
Vauzour, D, Buonfiglio, M, Corona, G, Chirafisi, J, Vafeiadou, K, Angeloni, C, Hrelia, S, Hrelia, P and Spencer, JPE (2010) Sulforaphane protects cortical neurons against 5-S-cysteinyl-dopamine-induced toxicity through the activation of ERK1/2, Nrf-2 and the upregulation of detoxification enzymes. Molecular Nutrition & Food Research, 54 (4). pp. 532-42.
Vauzour, D, Corona, G and Spencer, JPE (2010) Caffeic acid, tyrosol and p-coumaric acid are potent inhibitors of 5-S-cysteinyl-dopamine induced neurotoxicity. Archives of Biochemistry and Biophysics, 501 (1). pp. 106-11.
Vauzour, D, Houseman, ej, George, TW, Corona, G, Garnotel, R, Jackson, KG, Sellier, C, Gillery, P, Kennedy, OB, Lovegrove, JA and Spencer, JPE (2010) Moderate Champagne consumption promotes an acute improvement in acute endothelIal-independent vascular function in healthy human volunteers. The British Journal of Nutrition, 103 (8). pp. 1168-78.
Vauzour, D, Ravaioli, G, Vafeiadou, K, Rodriguez-Mateos, A, Angeloni, C and Spencer, JPE (2008) Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: implications for Parkinson's disease and protection by polyphenols. Archives of Biochemistry and Biophysics, 476 (2). pp. 145-51.
Vauzour, D, Vafeiadou, K, Rodriguez-Mateos, A, Rendeiro, C and Spencer, JPE (2008) The neuroprotective potential of flavonoids: a multiplicity of effects. Genes & Nutrition, 3 (3-4). pp. 115-26.
Williams, CM, El Mohsen, MA, Vauzour, D, Rendeiro, C, Butler, LT, Ellis, JA, Whiteman, M and Spencer, JPE (2008) Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels. Free Radical Biology & Medicine, 45 (3). pp. 295-305.
Vauzour, D, Vafeiadou, K, Rice-Evans, C, Williams, RJ and Spencer, JPE (2007) Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons. Journal of Neurochemistry, 103 (4). pp. 1355-67.
External Activities and Indicators of Esteem
- Invited and current member of the editorial board of: Nutrition and Aging; Neuroscience & Medicine; Journal of Food Science and Engineering
- Member of the “Groupe Polyphenols” Board Committee (http://www.groupepolyphenols.com/)
- Member of the Alcohol in Moderation’s Social, Scientific and Medical Council (http://www.aim-digest.com/)
- Invited and chartered member of the IFSAR (International Scientific Forum on Alcohol Research) (http://www.bu.edu/alcohol-forum/)
- Referee for research proposals submitted to the Alzheimer’s Association and the French National Research Agency (ANR).
- I regularly review manuscripts for the Journal of Cellular and Molecular Medicine, Free Radicals in Biology and Medicine; European Journal of Nutrition; Journal of neurochemistry, Food and chemical Toxicology, Food & Function; British Journal of Pharmacology; Neuropharmacology; Brain Research, Genes & Nutrition; Journal of Wine Research; Cell Biology and Toxicology; British Journal of Nutrition; Nutrition and Cancer, Cellular & Molecular Biology Letters and Archives of Biochemistry and Biophysics.
- Invited speaker Nov 2011: 6th International Wine and Heart Health Summit, Newberg, Oregon
- Outreach July 2010: “Antioxidants and brain health benefits” (Decision News Media, Brussels); http://www.nutraingredients.com/Research/Antioxidants-demonstrate-brain-health-benefits
- Invited speaker June 2010: Antioxidants 2010: Science, testing and regulation, Brussels, Belgium
- Invited speaker Jan 2009: National Institute of Human Nutrition (IRNHA), Bordeaux, France
- Invited speaker Sept 2009: 5th Probiotics, Prebiotics & New Foods Meeting, Rome, Italy
- Invited speaker Dec 2006: International Networking for Young Scientists (INYS), Lund, Sweden