Career History

  • Post Doctoral Researcher 2004 - 2005 EBV Group, Dept. of Medicine and Therapeutics, University of Aberdeen, Scotland.
  • Post Doctoral Researcher 2001 - 2004 Dept. of Medicine and Therapeutics, University of Aberdeen, Scotland.
  • Research Assistant 1998 - 1998 Dept. of Medicine and Therapeutics, University of Aberdeen, Scotland.

Academic Background

  • Ph.D. in Medicine. 1998 – 2001 University of Aberdeen, Scotland.
  • M.Sc. (Distinction) in Biomedical Sciences 1996 – 1997
    University Of Ulster, Coleraine, Northern Ireland
  • B.Sc. Hons Biotechnology 1992 – 1996
    Dublin City University, Ireland.

All Publications

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Dubourg, A., Xia, D., Winpenny, J. P., Al Naimi, S., Bouzid, M., Sexton, D. W., Wastling, J. M., Hunter, P. R., Tyler, K. M.

(2018)

Giardia secretome highlights secreted tenascins as a key component of pathogenesis,

in GigaScience

7

(3)

pp. 1-13

Full Text UEA Repository

(Article)

(Published)


Hanson, K., Robinson, S., Al-Yousuf, K., Hendry, A., Sexton, D., Sherwood, V., Wheeler, G.

(2018)

The anti-rheumatic drug, leflunomide, synergizes with MEK inhibition to suppress melanoma growth,

in Oncotarget

9

pp. 3815-3829

Full Text UEA Repository

(Article)

(Published)


Kotecha, J., Shulgina, L., Sexton, D. W., Atkins, C. P., Wilson, A. M.

(2016)

Plasma Vascular Endothelial Growth Factor Concentration and Alveolar Nitric Oxide as Potential Predictors of Disease Progression and Mortality in Idiopathic Pulmonary Fibrosis,

in Journal of Clinical Medicine

5

(9)

article no. 80

Full Text UEA Repository

(Article)

(Published)


Steverding, D., Tyler, K. K., Sexton, D. W.

(2016)

Evaluation of marking of peer-marking in oral presentation,

in Perspectives on Medical Education

5

(2)

pp. 103-107

Full Text UEA Repository

(Article)

(Published)


Bidula, S., Sexton, D. W., Schelenz, S.

(2016)

Serum opsonin ficolin-A enhances host–fungal interactions and modulates cytokine expression from human monocyte-derived macrophages and neutrophils following Aspergillus fumigatus challenge,

in Medical Microbiology and Immunology

205

(2)

pp. 133-142

Full Text UEA Repository

(Article)

(Published)


Bidula, S., Sexton, D. W., Yates, M., Abdolrasouli, A., Shah, A., Wallis, R., Reed, A., Armstrong-James, D., Schelenz, S.

(2015)

H-ficolin binds Aspergillus fumigatus leading to activation of the lectin complement pathway and modulation of lung epithelial immune responses,

in Immunology

146

(2)

pp. 281-291

Full Text UEA Repository

(Article)

(Published)


Wang, W., He, Y., Yu, G., Li, B., Sexton, D. W., Wileman, T., Roberts, A. A., Hamilton, C. J., Liu, R., Chao, Y., Shan, Y., Bao, Y.

(2015)

Sulforaphane protects the liver against CdSe quantum dot-induced cytotoxicity,

in PLoS ONE

10

(9)

article no. e0138771

Full Text UEA Repository

(Article)

(Published)


Jacques, R. O., Mills, S. C., Cazzonatto Zerwes, P., Fagade, F. O., Green, J. E., Downham, S., Sexton, D. W., Mueller, A.

(2015)

Dynamin function is important for CC-chemokine receptor induced cell migration,

in Cell Biochemistry and Function

33

(6)

pp. 407-414

Full Text UEA Repository

(Article)

(Published)


Bidula, S., Sexton, D. W., Abdolrasouli, A., Shah, A., Reed, A., Armstrong-James, D., Schelenz, S.

(2015)

The Serum Opsonin L-ficolin Is Detected in Lungs of Human Transplant Recipients Following Fungal Infections and Modulates Inflammation and Killing of Aspergillus fumigatus,

in Journal of Infectious Diseases

212

(2)

pp. 234-246

Full Text UEA Repository

(Article)

(Published)


Ellis, S., Sexton, D., Steverding, D.

(2015)

Trypanotoxic activity of thiosemicarbazone iron chelators,

in Experimental Parasitology

150

pp. 7-12

Full Text UEA Repository

(Article)

(Published)


Campwala, H., Sexton, D. W., Crossman, D. C., Fountain, S. J.

(2014)

P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells,

in Journal of Cell Science

127

(22)

pp. 4964-4973

Full Text UEA Repository

(Article)

(Published)


Wills, Q. F., Livak, K. J., Tipping, A. J., Enver, T., Goldson, A. J., Sexton, D. W., Holmes, C.

(2013)

Single-cell gene expression analysis reveals genetic associations masked in whole-tissue experiments,

in Nature Biotechnology

31

(8)

pp. 748-52

Full Text UEA Repository

(Article)

(Published)


Bidula, S., Kenawy, H., Ali, Y. M., Sexton, D., Schwaeble, W. J., Schelenz, S.

(2013)

Role of ficolin-A and lectin complement pathway in the innate defense against pathogenic Aspergillus species,

in Infection and Immunity

81

(5)

pp. 1730-40

Full Text UEA Repository

(Article)

(Published)


Kerr, J., Jacques, R., Moyano Cardaba, C., Tse, T., Sexton, D., Mueller, A.

(2013)

Differential regulation of chemotaxis: Role of Gβγ in chemokine receptor-induced cell migration,

in Cellular Signalling

25

(4)

pp. 729-735

Full Text UEA Repository

(Article)

(Published)


Schelenz, S., Kirchhof, N., Bidula, S., Wallis, R., Sexton, D.

(2013)

Opsonizing properties of rat ficolin-A in the defence against Cryptococcus neoformans.,

in Immunobiology

218

(4)

pp. 477-83

UEA Repository

(Article)

(Published)


Livak, K. J., Wills, Q. F., Tipping, A. J., Datta, K., Mittal, R., Goldson, A. J., Sexton, D. W., Holmes, C. C.

(2013)

Methods for qPCR gene expression profiling applied to 1440 lymphoblastoid single cells,

in Methods

59

(1)

pp. 71-9

Full Text UEA Repository

(Article)

(Published)


Steverding, D., Sexton, D. W.

(2013)

Trypanocidal activity of salinomycin is due to sodium influx followed by cell swelling,

in Parasites & Vectors

6

article no. 78

Full Text UEA Repository

(Article)

(Published)


Phillips, E. A., Sexton, D. W., Steverding, D.

(2013)

Bitter melon extract inhibits proliferation of Trypanosoma brucei bloodstream forms in vitro,

in Experimental Parasitology

133

(3)

pp. 353-6

Full Text UEA Repository

(Article)

(Published)


Steverding, D., Sexton, D. W., Chrysochoidi, N., Cao, F.

(2012)

Trypanosoma brucei transferrin receptor can bind C-lobe and N-lobe fragments of transferrin,

in Molecular and Biochemical Parasitology

185

(2)

pp. 99-105

Full Text UEA Repository

(Article)

(Published)


Steverding, D., Sexton, D. W., Wang, X., Gehrke, S. S., Wagner, G. K., Caffrey, C. R.

(2012)

Trypanosoma brucei: chemical evidence that cathepsin L is essential for survival and a relevant drug target,

in International Journal for Parasitology

42

(5)

pp. 481-8

Full Text UEA Repository

(Article)

(Published)


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Key Research Interests

My research focuses on airway inflammation resolution. I have an interest in the induction of apoptosis in granulocytes and their subsequent removal via phagocytosis by airway epithelial cells and alveolar macrophages. In trying to elucidate the mechanisms of recognition of apoptotic cells by phagocytes I have begun to focus on sugar changes on the apoptotic cell surface and how these are identified. Siglecs and ficolins are presently being studied to explicate their role in airway homeostasis and disease aetiology.  The pro-active role of the epithelium in airway inflammation continues to burgeon and I continue to examine immunomodulatory activity following epithelial cell phagocytic activity and the introduction of drugs, such as Thalidomide.

I work closely with Dr Andrew Wilson, Senior Respiratory Consultant, at the NNUH and Lecturer in MED, who has engaged several pharmaceutical companies to perform clinical trials based here at UEA.

Research Group Membership

Biomedicine

Teaching Interests

My teaching interests are in providing medical students with an understanding of the basic sciences and immunology.

Within my teaching remit I perform the following duties.

  1. MB/BS Unit 3 Academic Lead & part of MB/BS Year 2 Academic team.
  2. Member of the Curriculum Design and Development (CDD) team.
  3. MB/BS SSS Year 1 Biochemistry and Cellular Pathology Domain Lead.
  4. MB/BS PBL Tutor
  5. MB/BS OSCE assessor
  6. Interviewer and UCAS applications assessor for MB/BS course.
  7. Lecturer and seminar giver on MB/BS medical degree course (all years).
  8. Unit 4 (Research Funding) Lead on the newly instigated MSc in Health Research.

External Activities and Indicators of Esteem

  • Published two invited editorials for the Journal of Clinical and Experimental Allergy
  • Reviewer/Referee for Journal of Clinical and Experimental Allergy
  • Reviewer/Referee for British Journal of Pharmacology
  • Reviewer/Referee for Cell Death and Differentiation
  • Reviewer/Referee for Current Drug Targets - Inflammation and Allergy
  • Grant Referee for BBSRC

Administrative Posts

  • MB/BS Unit 3 Academic Lead & part of MB/BS Year 2 Academic team
  • Member of the Curriculum Design and Development (CDD) team
  • MB/BS SSS Year 1 Biochemistry and Cellular Pathology Domain Lead
  • MB/BS PBL Tutor
  • MB/BS OSCE assessor
  • Interviewer and UCAS applications assessor for MB/BS course
  • Academic representative on the School of Medicine’s Health and Safety Committee
  • Lecturer and seminar giver on MB/BS course (all years)
  • Unit 4 (Research Funding) Lead on the newly MSc in Health Research