All Publications

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Alshaker, H., Wang, Q., Srivats, S., Chao, Y., Cooper, C., Pchejetski, D.

(2017)

New FTY720-docetaxel nanoparticle therapy overcomes FTY720-induced lymphopenia and inhibits metastatic breast tumour growth,

in Breast Cancer Research and Treatment

165

(3)

pp. 531–543

Full Text UEA Repository

(Article)

(Published)


Camacho, N., Van Loo, P., Edwards, S., Kay, J., Matthews, L., Haase, K., Clark, J., Dennis, N., Thomas, S., Kremeyer, B., Zamora, J., Butler, A., Gundem, G., Merson, S., Luxton, H., Hawkins, S., Ghori, M., Marsden, L., Lambert, A., Karaszi, K., Pelvender, G., Massie, C., Kote-Jarai, Z., Raine, K., Jones, D., Howat, W., Hazell, S., Livni, N., Fisher, C., Ogden, C., Kumar, P., Thompson, A., Nicol, D., Mayer, E., Dudderidge, T., Yu, Y., Zhang, H., Shah, N., Gnanapragasam, V., Isaacs, W., Visakorpi, T., Hamdy, F., Berney, D., Verrill, C., Warren, A., Wedge, D., Lynch, A., Foster, C., Lu, Y. J., Bova, G. S., Whitaker, H., McDermott, U., Neal, D., Eeles, R., Cooper, C., Brewer, D.

(2017)

Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data,

in PLoS Genetics

13

(9)

article no. e1007001

Full Text UEA Repository

(Article)

(Published)


Wang, Q., Alshaker, H., Böhler, T., Srivats, S., Chao, Y., Cooper, C., Pchejetski, D.

(2017)

Core shell lipid-polymer hybrid nanoparticles with combined docetaxel and molecular targeted therapy for the treatment of metastatic prostate cancer,

in Scientific Reports

7

article no. 5901

Full Text UEA Repository

(Article)

(Published)


Stankiewicz, E., Mao, X., Mangham, D. C., Xu, L., Yeste-Velasco, M., Fisher, G., North, B., Chaplin, T., Young, B., Wang, Y., Kaur Bansal, J., Kudahetti, S., Spencer, L., Foster, C. S., Møller, H., Scardino, P., Oliver, R. T., Shamash, J., Cuzick, J., Cooper, C. S., Berney, D. M., Lu, Y.

(2017)

Identification of FBXL4 as a Metastasis Associated Gene in Prostate Cancer,

in Scientific Reports

7

article no. 5124

Full Text UEA Repository

(Article)

(Published)


Pellegrini, K. L., Patil, D., Douglas, K. J., Lee, G., Wehrmeyer, K., Torlak, M., Clark, J., Cooper, C. S., Moreno, C. S., Sanda, M. G.

(2017)

Detection of prostate cancer-specific transcripts in extracellular vesicles isolated from post-DRE urine,

in The Prostate

77

(9)

pp. 990-999

Full Text UEA Repository

(Article)

(Published)


Luca, B., Brewer, D. S., Edwards, D. R., Edward, S., Whitaker, H. C., Merson, S., Denis, N., Cooper, R. A., Hazell, S., Warren, A. Y., Eeles, R., Lynch, A. G., Ross-Adams, H., Lamb, A. D., Neal, D. E., Sethia, K., Mills, R. D., Ball, R. Y., Curley, H., Clark, J., Moulton, V., Cooper, C. S.

(2017)

DESNT: a poor prognosis category of human prostate cancer,

in European Urology Focus

Full Text UEA Repository

(Article)

(E-pub ahead of print)


Luedeke, M., Rinckleb, A. E., Fitzgerald, L. M., Geybels, M. S., Schleutker, J., Eeles, R. A., Teixeira, M. R., Cannon-Albright, L., Ostrander, E. A., Weikert, S., Herkommer, K., Wahlfors, T., Visakorpi, T., Leinonen, K. A., Tammela, T. L., Cooper, C. S., Kote-Jarai, Z., Edwards, S., Goh, C. L., McCarthy, F., Parker, C., Flohr, P., Paulo, P., Jerónimo, C., Henrique, R., Krause, H., Wach, S., Lieb, V., Rau, T. T., Vogel, W., Kuefer, R., Hofer, M. D., Perner, S., Rubin, M. A., Agarwal, A. M., Easton, D. F., Amin Al Olama, A., Benlloch, S., Hoegel, J., Stanford, J. L., Maier, C.

(2016)

Prostate cancer risk regions at 8q24 and 17q24 are differentially associated with somatic TMPRSS2:ERG fusion status,

in Human Molecular Genetics

25

(24)

pp. 5490-5499

Full Text UEA Repository

(Article)

(Published)


Alshaker, H., Wang, Q., Kawano, Y., Arafat, T., Böhler, T., Winkler, M., Cooper, C., Pchejetski, D.

(2016)

Everolimus (RAD001) sensitizes prostate cancer cells to docetaxel by down-regulation of HIF-1α and sphingosine kinase 1,

in Oncotarget

7

(49)

pp. 80943-80956

Full Text UEA Repository

(Article)

(Published)


Behjati, S., Gundem, G., Wedge, D. C., Roberts, N. D., Tarpey, P. S., Cooke, S. L., Van Loo, P., Alexandrov, L. B., Ramakrishna, M., Davies, H., Nik-Zainal, S., Hardy, C., Latimer, C., Raine, K. M., Stebbings, L., Menzies, A., Jones, D., Shepherd, R., Butler, A. P., Teague, J. W., Jorgensen, M., Khatri, B., Pillay, N., Shlien, A., Futreal, P. A., Badie, C., Cooper, C. S., Eeles, R. A., Easton, D., Foster, C., Neal, D. E., Brewer, D. S., Hamdy, F., Lu, Y., Lynch, A. G., Massi, C. E., Ng, A., Whitaker, H. C., Yu, Y., Zhang, H., Bancroft, E., Berney, D., Camacho, N., Corbishley, C., Dadaev, T., Dennis, N., Dudderidge, T., Edwards, S., Fisher, C., Ghori, J., Gnanapragasam, V. J., Greenman, C., Hawkins, S., Hazell, S., Howat, W., Karaszi, K., Kay, J., Kote-Jarai, Z., Kremeyer, B., Kumar, P., Lambert, A., Leongamornlert, D., Livni, N., Luxton, H., Matthews, L., Mayer, E., Merson, S., Nicol, D., Ogden, C., O’Meara, S., Pelvender, G., Shah, N. C., Tavare, S., Thomas, S., Thompson, A., Verrill, C., Warren, A., Zamora, J., McDermott, U., Bova, G. S., Richardson, A. L., Flanagan, A. M., Stratton, M. R., Campbell, P. J.

(2016)

Mutational signatures of ionizing radiation in second malignancies,

in Nature Communications

7

article no. 12605

Full Text UEA Repository

(Article)

(Published)


Pal, R. P., Kockelbergh, R. C., Pringle, J. H., Cresswell, L., Hew, R., Dormer, J. P., Cooper, C., Mellon, J. K., Barwell, J. G., Hollox, E. J.

(2016)

Immunocytochemical detection of ERG expression in exfoliated urinary cells identifies with high specificity patients with prostate cancer,

in BJU International

117

(4)

pp. 686-696

Full Text UEA Repository

(Article)

(Published)


White, C., Alshaker, H., Cooper, C., Winkler, M., Pchejetski, D.

(2016)

The emerging role of FTY720 (Fingolimod) in cancer treatment,

in Oncotarget

7

(17)

pp. 23106-23127

Full Text

(Literature review)

(Published)


Cooper, C. S., Clark, J., Brewer, D. S., Edwards, D. R.

(2016)

Prostate Single Nucleotide Polymorphism Provides a Crucial Clue to Cancer Aggression in Active Surveillance Patients,

in European Urology

69

(2)

pp. 229-30

Full Text

(Editorial)

(Published)


Ross-Adams, H., Lamb, A., Dunning, M., Halim, S., Lindberg, J., Massie, C., Egevad, L., Russell, R., Ramos-Montoya, A., Vowler, S., Sharma, N., Kay, J., Whitaker, H., Clark, J., Hurst, R., Gnanapragasam, V., Shah, N., Warren, A., Cooper, C., Lynch, A., Stark, R., Mills, I., Groenberg, H., Neal, D.

(2015)

Integration of copy number and transcriptomics provides risk stratification in prostate cancer: A discovery and validation cohort study,

in EBioMedicine

2

(9)

pp. 1133–1144

Full Text UEA Repository

(Article)

(Published)


Gundem, G., Van loo, P., Kremeyer, B., Alexandrov, L., Tubio, J. M. C., Papaemmanuil, E., Brewer, D., Kallio, H., Högnäs, H., Annala, M., Kivinummi, K., Goody, V., Latimer, C., O'Meara, S., Dawson, K., Isaacs, W., Emmert-Buck, M. R., Nykter, M., Foster, C. S., Kote-Jarai, Z., Easton, D. F., Whitaker, H. C., Neal, D. E., Cooper, C., Eeles, R. A., Visakorpi, T., Campbell, P., Mcdermott, U., Wedge, D. C., Bova, G. S.

(2015)

The Evolutionary History of Lethal Metastatic Prostate Cancer,

in Nature

520

(7547)

pp. 353–357

Full Text

(Letter)

(Published)


Massie, C. E., Spiteri, I., Ross-Adams, H., Luxton, H. J., Kay, J., Whitaker, H. C., Dunning, M. J., Lamb, A. D., Ramos-Montoya, A., Brewer, D., Cooper, C., Eeles, R. A., Warren, A. Y., Tavaré, S., Neal, D. E., Lynch, A. G.

(2015)

HES5 silencing is an early and recurrent change in prostate tumourigenesis,

in Endocrine-Related Cancer (ERC)

22

(2)

pp. 131-144

Full Text UEA Repository

(Article)

(Published)


Cooper, C., Eeles, R. A., Wedge, D. C., Van loo, P., Gundem, G., Alexandrov, L., Kreymer, B., Butler, A., Lynch, A., Edwards, S. E., Camacho, N., Massie, C. E., Kote-Jarai, Z., Dennis, N., Merson, S., Leongamornlert, D. A., Zamora, J., Kay, J., Luxton, H. J., Corbishley, C., Thomas, S., Nik-zainal, S., O'Meara, S., Matthews, L., Clark, J., Hurst, R., Mithen (IFR), R., Bristow (Ontario Cancer Inst. CA), R., Boutros, P. C., Fraser, M., Cooke, S., Raine, K., Jones, D., Menzies, A., Stebbings, L., Hinton, J., Teague, J., Mclaren, S., Mudie, L., Hardy, C., Anderson, E., Joseph, O., Goody, V., Robinson, B., Maddison, M., Gamble, S., Greenman, C., Berney, D., Hazell, S., Livni, N., Fisher, C., Ogden, C., Kumar, P., Thompson, A., Woodhouse, C. J., Nicol, D., Mayer, E., Dudderidge, T., Shah, N., Gnanapragasam (Cambridge), V., Voet, T., Campbell, P., Futreal, P. A., Easton, D. F., Warren, A. Y., Foster, C. S., Stratton, M. R., Whitaker, H. C., Mcdermott, U., Brewer, D., Neal, D. E.

(2015)

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue,

in Nature Genetics

47

pp. 367–372

Full Text

(Letter)

(Published)


Alshaker, H., Wang, Q., Frampton, A. E., Krell, J., Waxman, J., Winkler, M., Stebbing, J., Cooper, C., Yaguee, E., Pchejetski, D.

(2015)

Sphingosine kinase 1 contributes to leptin-induced STAT3 phosphorylation through IL-6/gp130 transactivation in oestrogen receptor-negative breast cancer,

in Breast Cancer Research and Treatment

149

(1)

pp. 59-67

Full Text UEA Repository

(Article)

(Published)


Manson-Bahr, D., Ball, R., Gundem, G., Mills, R., Rochester, M., Goody, V., O'Meara, S., Flather, M., Keeling, M., Yazbek Hanna, M., Hurst, R., Curley, H., Clark, J., Brewer, D., Mcdermott, U., Cooper, C.

(2015)

Mutation detection in formalin-fixed prostate cancer biopsies taken at the time of diagnosis using next generation DNA sequencing,

in Journal of Clinical Pathology

68

pp. 212-217

Full Text UEA Repository

(Article)

(Published)


Ju, Y. S., Tubio, J. M., Mifsud, W., Fu, B., Davies, H. R., Ramakrishna, M., Li, Y., Yates, L., Gundem, G., Tarpey, P. S., Behjati, S., Papaemmanuil, E., Martin, S., Fullam, A., Gerstung, M., Nangalia, J., Green, A. R., Caldas, C., Borg, Å., Tutt, A., Lee, M. T. M., Van't Veer, L. J., Tan, B. K., Aparicio, S., Span, P. N., Martens, J. W., Knappskog, S., Vincent-salomon, A., Børresen-dale, A., Eyfjörd, J. E., Flanagan, A. M., Foster, C., Neal, D. E., Cooper, C., Eeles, R., Lakhani, S. R., Desmedt, C., Thomas, G., Richardson, A. L., Purdie, C. A., Thompson, A. M., Mcdermott, U., Yang, F., Nik-zainal, S., Campbell, P. J., Stratton, M. R.

(2015)

Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells,

in Genome Research

25

(6)

pp. 814-824

Full Text UEA Repository

(Article)

(Published)


Boutros, P. C., Fraser, M., Harding, N. J., De Borja, R., Trudel, D., Lalonde, E., Meng, A., Hennings-yeomans, P. H., Mcpherson, A., Sabelnykova, V. Y., Zia, A., Fox, N. S., Livingstone, J., Shiah, Y., Wang, J., Beck, T. A., Have, C. L., Chong, T., Sam, M., Johns, J., Timms, L., Buchner, N., Wong, A., Watson, J. D., Simmons, T. T., P'ng, C., Zafarana, G., Nguyen, F., Luo, X., Chu, K. C., Prokopec, S. D., Sykes, J., Dal Pra, A., Berlin, A., Brown, A., Chan-seng-yue, M. A., Yousif, F., Denroche, R. E., Chong, L. C., Chen, G. M., Jung, E., Fung, C., Starmans, M. H. W., Chen, H., Govind, S. K., Hawley, J., D'costa, A., Pintilie, M., Waggott, D., Hach, F., Lambin, P., Muthuswamy, L. B., Cooper, C., Eeles, R., Neal, D., Tetu, B., Sahinalp, C., Stein, L. D., Fleshner, N., Shah, S. P., Collins, C. C., Hudson, T. J., Mcpherson, J. D., Van Der Kwast, T., Bristow, R. G.

(2015)

Spatial genomic heterogeneity within localized, multifocal prostate cancer,

in Nature Genetics

47

pp. 736–745

Full Text UEA Repository

(Article)

(Published)


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