All Publications

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Williams, D., Fothergill, J. L., Evans, B., Caples, J., Haldenby, S., Walshaw, M. J., Brockhurst, M. A., Winstanley, C., Paterson, S.

(2018)

Transmission and lineage displacement drive rapid population genomic flux in cystic fibrosis airway infections of a Pseudomonas aeruginosa epidemic strain,

in Microbial Genomics

4

Full Text UEA Repository

(Article)

(Published)


Miller, E., Evans, B. A., Cornejo, O. E., Roberts, I. S., Rozen, D. E.

(2017)

Pherotype polymorphism in Streptococcus pneumoniae has no obvious effects on population structure and recombination,

in Genome Biology and Evolution

9

(10)

pp. 2546–2559

Full Text UEA Repository

(Article)

(Published)


AbuHassan, K., Bakhori, N., Kusnin, N., Azmi, U., Tania, M., Evans, B., Yusof, N., Hossain, A.

(2017)

Automatic diagnosis of tuberculosis disease based on Plasmonic ELISA and color-based image classification,

in Engineering in Medicine and Biology Society (EMBC), 2017 39th Annual International Conference of the IEEE .

The Institute of Electrical and Electronics Engineers (IEEE)

ISBN 978-1-5090-2810-8

Full Text

(Conference contribution)

(Published)


Evans, B. A.

(2016)

Comment on: Resistance gene naming and numbering: is it a new gene or not?,

in Journal of Antimicrobial Chemotherapy

71

(6)

pp. 1742-1743

Full Text

(Comment/debate)

(Published)


Vali, L., Dashti, K., Opazo-Capurro, A. F., Dashti, A. A., Al Obaid, K., Evans, B. A.

(2015)

Diversity of multi-drug resistant Acinetobacter baumannii population in a major hospital in Kuwait,

in Frontiers in Microbiology

6

article no. 743

Full Text UEA Repository

(Article)

(Published)


Al-Sultan, A. A., Evans, B. A., Aboulmagd, E., Al-Qahtani, A. A., Bohol, M. F. F., Al-Ahdal, M. N., Opazo, A. F., Amyes, S. G. B.

(2015)

Dissemination of multiple carbapenem-resistant clones of Acinetobacter baumannii in the Eastern District of Saudi Arabia,

in Frontiers in Microbiology

6

article no. 634

Full Text UEA Repository

(Article)

(Published)


Williams, D., Evans, B., Haldenby, S., Walshaw, M. J., Brockhurst, M. A., Winstanley, C., Paterson, S.

(2015)

Divergent, coexisting Pseudomonas aeruginosa lineages in chronic cystic fibrosis lung infections,

in American Journal of Respiratory and Critical Care Medicine

191

(7)

pp. 775-785

Full Text UEA Repository

(Article)

(Published)


Alsultan, A. A., Aboulmagd, E., Evans, B. A., Amyes, S. G. B.

(2014)

Clonal diversity of Acinetobacter baumannii from diabetic patients in Saudi Arabian hospitals,

in Journal of Medical Microbiology

63

pp. 1460-1466

Full Text UEA Repository

(Article)

(Published)


Evans, B. A., Amyes, S. G. B.

(2014)

OXA β-lactamases,

in Clinical Microbiology Reviews

27

(2)

pp. 241-263

Full Text UEA Repository

(Article)

(Published)


Amyes, S. G. B., Evans, B. A.

(2014)

Molecular Epidemiology of Antibiotic Resistance in Humans and Animals,

in Molecular Medical Microbiology .

Elsevier

pp. 599-609

ISBN 978-0-12-397169-2

UEA Repository

(Chapter)

(Published)


Alsultan, A. A., Evans, B. A., Elsayed, E. A., Al-Thawadi, S. I., Al-Taher, A. Y., Amyes, S. G. B., Al-Dughaym, A. M., Hamouda, A.

(2013)

High frequency of carbapenem-resistant Acinetobacter baumannii in patients with diabetes mellitus in Saudi Arabia,

in Journal of Medical Microbiology

62

pp. 885-888

Full Text UEA Repository

(Article)

(Published)


Evans, B. A., Rozen, D. E.

(2013)

Significant variation in transformation frequency in Streptococcus pneumoniae,

in The ISME Journal

7

pp. 791-799

Full Text UEA Repository

(Article)

(Published)


Evans, B. A., Hamouda, A., Amyes, S. G. B.

(2013)

The rise of carbapenem-resistant Acinetobacter baumannii,

in Current Pharmaceutical Design

19

(2)

pp. 223-238

Full Text UEA Repository

(Article)

(Published)


Evans, B. A., Rozen, D. E.

(2012)

A Streptococcus pneumoniae infection model in larvae of the wax moth Galleria mellonella,

in European Journal of Clinical Microbiology & Infectious Diseases

31

(10)

pp. 2653-2660

Full Text UEA Repository

(Article)

(Published)


Lopes, B. S., Evans, B. A., Amyes, S. G. B.

(2012)

Disruption of the blaOXA-51-like gene by ISAba16 and activation of the blaOXA-58 gene leading to carbapenem resistance in Acinetobacter baumannii Ab244,

in Journal of Antimicrobial Chemotherapy

67

(1)

pp. 59-63

Full Text UEA Repository

(Article)

(Published)


Evans, B. A., Hamouda, A., Abbasi, S. A., Khan, F. A., Amyes, S. G. B.

(2011)

High prevalence of unrelated multidrug-resistant Acinetobacter baumannii isolates in Pakistani military hospitals,

in International Journal of Antimicrobial Agents

37

(6)

pp. 580-581

Full Text

(Letter)

(Published)


Towner, K. J., Evans, B., Villa, L., Levi, K., Hamouda, A., Amyes, S. G. B., Carattoli, A.

(2011)

Distribution of intrinsic plasmid replicase genes and their association with carbapenem-hydrolyzing class D beta-lactamase genes in European clinical isolates of Acinetobacter baumannii,

in Antimicrobial Agents and Chemotherapy

55

(5)

pp. 2154-2159

Full Text UEA Repository

(Article)

(Published)


Yang, J., Evans, B. A., Rozen, D. E.

(2010)

Signal diffusion and the mitigation of social exploitation in pneumococcal competence signalling,

in Proceedings of the Royal Society B: Biological Sciences

277

(1696)

pp. 2991-2999

Full Text UEA Repository

(Article)

(Published)


Hamouda, A., Evans, B. A., Towner, K. J., Amyes, S. G. B.

(2010)

Characterization of epidemiologically unrelated Acinetobacter baumannii isolates from four continents by use of multilocus sequence typing, pulsed-field gel electrophoresis, and sequence-based typing of bla(OXA-51-like) genes,

in Journal of Clinical Microbiology

48

(7)

pp. 2476-2483

Full Text UEA Repository

(Article)

(Published)


Jiricny, N., Diggle, S. P., West, S. A., Evans, B. A., Ballantyne, G., Ross-Gillespie, A., Griffin, A. S.

(2010)

Fitness correlates with the extent of cheating in a bacterium,

in Journal of Evolutionary Biology

23

(4)

pp. 738-747

Full Text UEA Repository

(Article)

(Published)


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Key Research Interests

  • Evolution of bacterial drug resistance mechanisms
  • Transmission of drug resistance in bacterial populations
  • Population dynamics of bacterial pathogens

The evolution and spread of antibiotic resistance

Bacteria can become resistant to antibiotics through a number of different mechanisms. These include intrinsic mechanism that all members of the bacterial species posses and that they switch on or ‘ramp up’ when exposed to antibiotics, and mechanisms that the bacteria acquire from external sources that can then be exchanged between bacteria.
 
My work centres on understanding which mechanisms bacteria are using to become resistant to antibiotics, and how these are evolving and being transferred in bacterial populations. An example of current work is investigating the effect of non-antibiotic drugs, such as cancer chemotherapies, on promoting antibiotic resistance. Many drugs used in healthcare coincidently have antibacterial properties, and therefore bacteria develop resistance against these. However, in doing so, some bacteria can become more resistant to antibiotics at the same time, even without having been exposed to any antibiotics. This ‘cross-resistance’, where exposure to one drug (e.g. a cancer chemotherapy) causes resistance to a different drug (e.g. an antibiotic) is not well understood despite its potential to have a major impact on the evolution and spread of antibiotic resistance. By understanding how different drugs cause cross-resistance to antibiotics we will gain a more holistic view of antibiotic resistance that can be exploited in the design and development of new drugs, and in the management and use of existing drugs.