Key research interests and themes Key research interests and themes

89% of the Department’s research was recently rated as world leading/internationally excellent in the Research Excellence Framework (REF2014) and our research publications were rated 6th in the UK (Sub-panel 6, REF2014). 

Key Research Interests include:

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  • Flavonoids and cardiometabolic health
  • n-3 fatty acids and the cardiometabolic phenotype
  • Phytochemical metabolites as potential therapeutic targets
  • Diet and age-related cognitive decline
  • Biomarkers of dietary exposure
  • Diet-gene interactions 
  • APOE genotype, health and response to dietary change
  • Determinants of flavonoid absorption and metabolism
  • Benefits and risks of dietary isothiocyanates


On-going projects include research on:

  • Impact of flavonoids and other bioactives on cardiometabolic health (including trials and prospective studies with the Harvard T. H. Chan School of Public Health)
  • Factors affecting the in vivo bioavailability of flavonoids
  • Molecular mechanisms of flavonoids and their metabolites
  • Effects of genotype on flavonoid metabolism 
  • Independent and interactive impact of select dietary components (in particular n-3 fatty acids and flavonoids) and common gene variants on cardiometabolic health
  • Impact of flavonoids and n-3 fatty acids on age-related cognitive decline 
  • Dietary n-3 fatty acids and cardiometabolic health with a focus on lipoprotein metabolism, vascular function and adipose tissue and liver inflammation
  • Aetiology of the association between the APOE4 genotype and chronic disease risk
  • Synergistic interactions between phytochemicals in relation to gene expression and miRNAs