Biography

Alpar is a lecturer and principle investigator at the school of Health Sciences with a strong research interest in the significance of human sleep and circadian rhythmicity in brain health. With more than 13 years of experience in sleep research Alpar has studied sleep and cognition in children and adults presenting normal and pathological development and aging. Following his PhD studies at Semmelweis University Budapest where he investigated the sleep physiological correlates of Asperger syndrome, he soon joined the Surrey Sleep Research Centre, UK where he studied the genetics of sleep-wake regulation and chronotype. His work has contributed to a better understanding of the impact of sleep-wake homeostasis and circadian rhythmicity on brain activity and cognition. As he gradually became more interested in pathological aging Alpar joined Cambridge University where he investigated the role of early sleep disturbances in Huntington’s disease (HD), an autosomal dominant neurodegenerative disorder and showed for the first time that sleep is one of the earliest homeostatic processes to go wrong in HD specific neurodegeneration. Alpar joined UEA by the end of 2016 and has been awarded a Wellcome trust seed award in science to establish his own group and study the impact of genetic risk factors for developing Alzheimer’s disease on sleep-wake regulation and cognition.

All Publications

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Simor, P., Harsányi, A., Csigó, K., Miklós, G., Lázár, A. S., Demeter, G.

(2018)

Eveningness is associated with poor sleep quality and negative affect in obsessive-compulsive disorder,

in Journal of Behavioral Addictions

7

(1)

pp. 10-20

Full Text UEA Repository

(Article)

(Published)


Ronai, K. Z., Szentkiralyi, A., Lazar, A. S., Lazar, Z. I., Papp, I., Gombos, F., Zoller, R., Czira, M. E., Lindner, A. V., Mucsi, I., Bodizs, R., Molnar, M. Z., Novak, M.

(2017)

Association of symptoms of insomnia and sleep parameters among kidney transplant recipients,

in Journal of Psychosomatic Research

99

pp. 95-104

Full Text UEA Repository

(Article)

(Published)


Ronai, K. Z., Szentkiralyi, A., Lazar, A. S., Ujszaszi, A., Turanyi, C., Gombos, F., Mucsi, I., Bodizs, R., Molnar, M. Z., Novak, M.

(2017)

Depressive symptoms are associated with objectively measured sleep parameters in kidney transplant recipients,

in Journal of Clinical Sleep Medicine

13

(4)

pp. 557–564

Full Text UEA Repository

(Article)

(Published)


Bartlett, D. M., Cruickshank, T. M., Hannan, A. J., Eastwood, P. R., Lazar, A. S., Ziman, M. R.

(2016)

Neuroendocrine and neurotrophic signaling in Huntington's disease: Implications for pathogenic mechanisms and treatment strategies,

in Neuroscience and Biobehavioral Reviews

71

pp. 444-454

Full Text UEA Repository

(Article)

(Published)


Atherton, K. E., Nobre, A. C., Lazar, A. S., Wulff, K., Whittaker, R. G., Dhawan, V., Lazar, Z. I., Zeman, A. Z., Butler, C. R.

(2016)

Slow wave sleep and accelerated forgetting,

in Cortex

84

pp. 80-89

Full Text UEA Repository

(Article)

(Published)


Santhi, N., Lazar, A. S., McCabe, P. J., Lo, J. C., Groeger, J. A., Dijk, D.

(2016)

Sex differences in the circadian regulation of sleep and waking cognition in humans,

in Proceedings of the National Academy of Sciences of the United States of America (PNAS)

113

(19)

pp. E2730-E2739

Full Text UEA Repository

(Article)

(Published)


Lazar, A. S., Panin, F., Goodman, A. O. G., Lazic, S. E., Lazar, Z. I., Mason, S. L., Rogers, L., Murgatroyd, P. R., Watson, L. P. E., Singh, P., Borowsky, B., Shneerson, J. M., Barker, R. A.

(2015)

Sleep deficits but no metabolic deficits in premanifest Huntington's disease,

in Annals of Neurology

78

(4)

pp. 630-648

Full Text UEA Repository

(Article)

(Published)


Kuan, W. L., Kasis, A., Yuan, Y., Mason, S. L., Lazar, A. S., Barker, R. A., Goncalves, J.

(2015)

Modelling the natural history of Huntington's disease progression,

in Journal of Neurology, Neurosurgery and Psychiatry

86

(10)

pp. 1143-1149

Full Text UEA Repository

(Article)

(Published)


Collins, L. M., Begeti, F., Panin, F., Lazar, A. S., Cruickshank, T., Ziman, M., Mason, S. L., Barker, R. A.

(2015)

Novel nut and bolt task quantifies motor deficits in premanifest and manifest Huntington's Disease,

in PLoS Currents Disasters

7

Full Text UEA Repository

(Article)

(Published)


Lazar, A. S., Lazar, Z. I., Dijk, D.

(2015)

Circadian regulation of slow waves in human sleep: Topographical aspects,

in NeuroImage

116

pp. 123-134

Full Text UEA Repository

(Article)

(Published)


Mason, S. L., Zhang, J., Begeti, F., Guzman, N. V., Lazar, A. S., Rowe, J. B., Barker, R. A., Hampshire, A.

(2015)

The role of the amygdala during emotional processing in Huntington's disease: From pre-manifest to late stage disease,

in Neuropsychologia

70

pp. 80-89

Full Text UEA Repository

(Article)

(Published)


Videnovic, A., Lazar, A. S., Barker, R. A., Overeem, S.

(2014)

'The clocks that time us' - circadian rhythms in neurodegenerative disorders,

in Nature Reviews Neurology

10

(12)

pp. 683-693

Full Text UEA Repository

(Article)

(Published)


Arbon, E. L., Lazar, A. S., Lo, J. C., Johnson, S., Dijk, D. -.

(2014)

Repeated sleep extension and sleep restriction in healthy young people leads to transient homeostatic responses in sleep and wake EEG,

in Journal of Sleep Research

23

(S1)

article no. P614

pp. 189

Full Text

(Abstract)

(Published)


Santhi, N., Lazar, A. S., Mccabe, P., Archer, S. N., Groeger, J. A., Dijk, D. -.

(2014)

Circadian regulation in cognition and subjective assessment of waking function in humans,

in Journal of Sleep Research

23

pp. 48

Full Text

(Abstract)

(Published)


Lazar, A. S., Lazar, Z. I., Dijk, D.

(2014)

Circadian regulation of EEG slow waves and phase coherence in human sleep,

in Journal of Sleep Research

23

(S1)

pp. 9

Full Text

(Abstract)

(Published)


Archer, S. N., Laing, E. E., Möller-Levet, C. S., van der Veen, D. R., Bucca, G., Lazar, A. S., Santhi, N., Slak, A., Kabiljo, R., von Schantz, M., Smith, C. P., Dijk, D.

(2014)

Mistimed sleep disrupts circadian regulation of the human transcriptome,

in Proceedings of the National Academy of Sciences of the United States of America (PNAS)

111

(6)

pp. E682-E691

Full Text UEA Repository

(Article)

(Published)


Lazar, A. S., Santhi, N., Hasan, S., Lo, J. C., Johnston, J. D., Von Schantz, M., Archer, S. N., Dijk, D.

(2013)

Circadian period and the timing of melatonin onset in men and women: Predictors of sleep during the weekend and in the laboratory,

in Journal of Sleep Research

22

(2)

pp. 155-159

Full Text UEA Repository

(Article)

(Published)


Arbon, E. L., Lazar, A. S., Lo, J. C., Slak, A., Mccabe, P. J., Boyle, J., Archer, S. N., Dijk, D.

(2012)

Individual differences in sleep revisited: Stability across sleep restriction, extension and total sleep loss,

in Journal of Sleep Research

21

(S1)

pp. 207-208

Full Text

(Abstract)

(Published)


Lo, J. C., Groeger, J. A., Santhi, N., Arbon, E. L., Lazar, A. S., Hasan, S., Von Schantz, M., Archer, S. N., Dijk, D. J.

(2012)

Effects of circadian phase and prior partial sleep deprivation on executive functions during total sleep deprivation are modulated by PER3 polymorphism,

in Journal of Sleep Research

21

(S1)

article no. O168

pp. 41

Full Text

(Abstract)

(Published)


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