Primary Supervisor: Dr Mark Webber - firstname.lastname@example.org
Secondary Supervisor: Gemma Langridge (QIB)
Bacterial genomes have evolved over billions of years to allow the efficient expression of the right genes at the right times. It has become clear that the same gene, placed in different locations around a bacterial chromosome can display very different levels of expression. The rules which govern this are however not fully understood. This project aims to examine how position within a genome can affect gene expression, this will help us both understand how genomes work and evolve, and allow us to rationally design synthetic chromosomes which will deliver an optimised expression of important genes.
The project will compare the expression of millions of copies of the same gene promoters in both Salmonella and E. coli - two related species which share some genome organisation but control gene expression differently. The project will make use of tools already developed to allow expression to be measured under different conditions and will involve a mix of molecular microbiology, transcriptomics and informatics.
The student will join a large community of molecular microbiologists within the Quadram Institute in a brand new, purpose-built building with state of the art facilities. The Quadram Institute is based on the Norwich Research Park - home to one of the largest groups of microbiologists in Europe and the student will join a large cohort of graduate researchers with exceptional training opportunities.
You can email Dr Mark Webber for informal enquiries.
The Norwich Research Park Biosciences Doctoral Training Partnership (NRPDTP) is open to UK and international candidates for entry in October 2022 and offers postgraduates the opportunity to undertake a 4-year PhD research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers.
All NRPDTP students undertake a three-month professional internship placement (PIPS) during their study. The placement offers exciting and invaluable work experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team. Students with, or expecting to attain, at least an upper second class honours degree, or equivalent, are invited to apply.
This project has been shortlisted for funding by the NRPDTP programme. Shortlisted applicants will be interviewed on Tuesday 25th January, Wednesday 26th January and Thursday 27th January 2022.
You can visit the Norwich Research Park Biosciences Doctoral Training Partnership pages for further information on eligibility and the application process.
Our partners value diverse and inclusive work environments that are positive and supportive. Students are selected for admission without regard to gender, marital or civil partnership status, disability, race, nationality, ethnic origin, religion or belief, sexual orientation, age or social background.