Over the last decade, several antibody-based biotherapeutics have been developed for the treatment of cancer. These antibodies, often marketed as “targeted therapeutics”, bind to cell surface receptors on cancer cells and direct them towards apoptosis (programmed cell death). However, the same cell surface receptors are also present on healthy cells, leading to severe side effects. If the binding of an antibody to its antigen could be activated at the site of cancer cells, it would reduce the side effects of antibody-based therapeutics. The long-term goal of this project is to develop antibodies that can be activated by light at the site of cancer cells, thereby reducing the side effects of therapeutic antibodies.
The successful applicant will be a talented biochemist or chemist with enthusiasm for chemistry, chemical biology, and molecular biology. The candidate will work at the forefront of chemical and synthetic biology and will develop advanced skills in chemical synthesis, various molecular biology and analytical techniques, including molecular cloning, protein expression and purification, gel electrophoresis, western blotting, and HPLC. The research work will be performed in the Chemical and Synthetic Biology laboratories housed in the School of Chemistry, the University of East Anglia under the supervision of Dr Amit Sachdeva and Dr Maria J. Marin.
The Norwich Research Park Biosciences Doctoral Training Partnership (NRPDTP) is open to the UK and international candidates for entry in October 2022 and offers postgraduates the opportunity to undertake a 4-year PhD research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP students undertake a three-month professional internship placement (PIPS) during their study. The placement offers exciting and invaluable work experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team. Students with, or expecting to attain, at least an upper second class honours degree, or equivalent, are invited to apply.
This project has been shortlisted for funding by the NRPDTP programme. Shortlisted applicants will be interviewed on Tuesday 25th January, Wednesday 26th January and Thursday 27th January 2022.
You can visit the Norwich Research Park Biosciences Doctoral Training Partnership for further information on eligibility and the application process.
Our partners value diverse and inclusive work environments that are positive and supportive. Students are selected for admission without regard to gender, marital or civil partnership status, disability, race, nationality, ethnic origin, religion or belief, sexual orientation, age or social background.