Primary Supervisor: Dr Yiliang Ding - Yiliang.Ding@jic.ac.uk
Secondary Supervisor: Anthony dodd (JIC, BIO)
The diversity of RNA structure is wide and varied, from hairpins and bulges through to triplex and quadruplexes. These structures are able to control numerous biological functions from sensing of messenger compounds to dictating whether genes are switched on or off. This project will focus in particular on G-quadruplexes, four-stranded RNA structures which are formed from sequences that contain a lot of the base guanine. This project will aim to reveal some of the RNA-based mechanisms which alter gene regulation in plants in response to stress (for example during periods of drought).
This PhD project will involve using biophysical and molecular biology techniques to determine the type of structures which the RNA is able to fold into, how they change in response to the environment and what happens to the biology when they form. The project will be highly interdisciplinary and will involve training in a wide range of techniques, from biophysical and physiological characterisation to in vivo testing in plants. Led by Dr Yiliang Ding and Dr Antony Dodd at the John Innes Centre along with Prof. Zoë Waller in the University College London, the successful applicant will enjoy the benefits of working in both a University environment and research institute.
The student will have, or expect to obtain a first class, 2(i) or equivalent Honours degree in Biology, Chemistry, Biochemistry, Pharmacy or a related area. Informal enquiries are welcomed; for further information please contact Dr Yiliang Ding (Yiliang.Ding@jic.ac.uk).
The Norwich Research Park Biosciences Doctoral Training Partnership (NRPDTP) is open to the UK and international candidates for entry in October 2022 and offers postgraduates the opportunity to undertake a 4-year PhD research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP students undertake a three-month professional internship placement (PIPS) during their study. The placement offers exciting and invaluable work experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team. Students with, or expecting to attain, at least an upper second class honours degree, or equivalent, are invited to apply.
This project has been shortlisted for funding by the NRPDTP programme. Shortlisted applicants will be interviewed on Tuesday 25th January, Wednesday 26th January and Thursday 27th January 2022.
You can visit the Norwich Research Park Biosciences Doctoral Training Partnership pages for further information on eligibility and the application process.
Our partners value diverse and inclusive work environments that are positive and supportive. Students are selected for admission without regard to gender, marital or civil partnership status, disability, race, nationality, ethnic origin, religion or belief, sexual orientation, age or social background.