Primary Supervisor: Dr Stephen Robinson - email@example.com
Secondary Supervisor: Samuel Fountain (UEA, BIO)
Angiogenesis is the formation of blood vessels from pre-exisitng vessels. It is essential for maintaining healthy physiological processes and for the revascularisation of tissues following an injury. Our research group focuses on investigating the molecular basis of angiogenesis and we have recently identified a novel interaction between three cell surface proteins expressed by endothelial cells involved in this process.
The goal of this studentship is to take a genetics approach to determine how endothelial alpha5-integrin, neuropilin-1, and neuropilin-2 proteins interact with one another to regulate angiogenesis at the molecular, cellular and organismal levels. We have generated conditionally knocked out mice deficient in their ability to express one or more of these proteins in endothelial cells. Working with these mice, or cells derived from these mice, the project would give the student experience in a wide range of cross-disciplinary techniques:
- Using the mouse retina as a model system to study angiogenesis in vivo.
- Working with endothelial cells in culture, learning how to study their angiogenic behaviour in vitro.
Techniques learned will include whole tissue imaging via confocal microscopy, Western blotting, adhesion and migration assays, immunocytochemistry, and biochemical assays to determine physical interactions between the three proteins.
The project offers students an opportunity to work in a dynamic environment, in a research institute with excellent facilities and resources for undertaking a wide variety of studies in the life-sciences. This opportunity is available for enthusiastic candidates with an interest in cell biology, molecular biology, developmental biology, and/or vascular biology.
The Norwich Research Park Biosciences Doctoral Training Partnership (NRPDTP) is open to the UK and international candidates for entry in October 2022 and offers postgraduates the opportunity to undertake a 4-year PhD research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers.
All NRPDTP students undertake a three-month professional internship placement (PIPS) during their study. The placement offers exciting and invaluable work experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team. Students with, or expecting to attain, at least an upper second class honours degree, or equivalent, are invited to apply.
This project has been shortlisted for funding by the NRPDTP programme. Shortlisted applicants will be interviewed on Tuesday 25th January, Wednesday 26th January and Thursday 27th January 2022.
You can visit the Norwich Research Park Biosciences Doctoral Training Partnership pages for further information on eligibility and the application process.
Our partners value diverse and inclusive work environments that are positive and supportive. Students are selected for admission without regard to gender, marital or civil partnership status, disability, race, nationality, ethnic origin, religion or belief, sexual orientation, age or social background.