Biography

Click here for current PhD opportunities in CHE. But feel free to email me to discuss projects outside these areas and alternative sources of funding.

1987. BSc. University of Bath.
1990. PhD. University of Warwick
1990 – 1991. Alexander von Humboldt Fellow, University of Heidelberg
1992 – 2001. Lecturer and Senior Lecturer, Cardiff University
2001 – 2007. Reader, Queen Mary, University of London. 

 

Catalysis is a key technology that will enable the sustainable discovery, synthesis and manufacture of new pharmaceuticals, agrochemicals and materials. My approach to achieving these goals involves the design and synthesis of novel organometallic compounds, and to investigate these as catalysts for the efficient enantioselective synthesis of high value chiral organic compounds from low value starting materials. These products are then used to generate new and potentially bioactive chiral heterocycles for application in drug-discovery programmes.

More information is available on the group website.

 

Selected Recent Publications

Deuterium as a Stereochemically Invisible Blocking Group for Chiral Ligand Synthesis

R. A. Arthurs and C. J. Richards, Org. Lett. 2017, 19, 702.

DOI: 10.1021/acs.orglett.6b03874

 

Metallocene to Metallocene Conversion. Synthesis of an Oxazoline-Substituted Pentamethyliridocenium Cation from a Ferrocenyloxazoline
R.  A. Arthurs, P. N. Horton, S. J. Coles and C.  J. Richards, Chem. Commun. 2016, 52, 7024.
DOI: 10.1039/C6CC01959E

 

Enantiopure ferrocene-based planar-chiral iridacycles: stereospecific control of iridium-centred chirality
R. A. Arthurs, M.  Ismail, C. C. Prior, V. S. Oganesyan, P. N. Horton, S. J. Coles and C. J. Richards, Chem. Eur. J. 2016, 22, 3065.
DOI: 10.1002/chem.201504458

 

Chirality Control in Planar Chiral Cobalt Oxazoline Palladacycles
D. J. Cassar, H. Roghzai, D. Villemin, P. N. Horton, S. J. Coles and Christopher J. Richards, Organometallics201534, 2953.
DOI: 10.1021/acs.organomet.5b00282



Enantioselective Synthesis and Application to the Allylic Imidate Rearrangement of Amine-Coordinated Palladacycle Catalysts of Cobalt Sandwich Complexes
D. J. Cassar, G. Ilyashenko, M. Ismail, J. Woods, D. L. Hughes and C. J. Richards, Chem. Eur. J.201319, 17951.
DOI: 10.1002/chem.201302922


Diastereoselective Synthesis of Half-Sandwich Chiral-at-Metal Cobaltacycles by Oxidative Cyclisation
J. Amin and C. J. Richards, Chem. Commun201248, 10192.

DOI: 10.1039/C2CC34837C

Regioselective, Stereoselective and Conformationally Controlled Synthesis of (eta4-Tetraarylcyclo-butadiene)(eta5-carbomethoxycyclopentadienyl)cobalt Metallocenes
D. Cassar, E. Nagaradja, D. C. D. Butler, D. Villemin and C. J. Richards, Org. Lett. 2012, 14, 894.
DOI: 10.1021/ol203415r



Synthesis of a [2.2]Paracyclophane Based Planar Chiral Palladacycle by a Highly Selective Kinetic Resolution/C-H Activation Reaction
N. Dendele, F. Bisaro, A.-C. Gaumont, S. Perrio and C. J. Richards, Chem. Commun. 2012, 48, 1991.
DOI: 10.1039/C2CC16864B

 

All Publications

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Richards, C. J., Arthurs, R.

(2017)

Catalyst optimisation for asymmetric synthesis by ligand chirality element addition - a perspective on stereochemical cooperativity,

in Chemistry - A European Journal

23

(48)

pp. 11460–11478

Full Text UEA Repository

(Article)

(Published)


Arthurs, R. A., Richards, C. J.

(2017)

Deuterium as a Stereochemically Invisible Blocking Group for Chiral Ligand Synthesis,

in Organic Letters

19

(3)

pp. 702-705

Full Text UEA Repository

(Article)

(Published)


Arthurs, R. A., Horton, P. N., Coles, S. J., Richards, C. J.

(2017)

Phenyl vs. Ferrocenyl Cyclometallation Selectivity: Diastereoselective Synthesis of an Enantiopure Iridacycle,

in European Journal of Inorganic Chemistry

2017

(2)

pp. 229–232

Full Text UEA Repository

(Article)

(Published)


Vincent, A., Deschamps, D., Martzel, T., Lohier, J. -., Richards, C. J., Gaumont, A., Perrio, S.

(2016)

Enantiomerically Pure [2.2]Paracyclophane-4-thiol: A Planar Chiral Sulfur-Based Building Block Readily Available by Resolution with an Amino Acid Chiral Auxiliary,

in Journal of Organic Chemistry

81

(9)

pp. 3961-3966

Full Text

(Comment/debate)

(Published)


Arthurs, R. A., Horton, P. N., Coles, S. J., Richards, C. J.

(2016)

Metallocene to metallocene conversion. Synthesis of an oxazoline-substituted pentamethyliridocenium cation from a ferrocenyloxazoline,

in Chemical Communications

52

(43)

pp. 7024-7027

Full Text UEA Repository

(Article)

(Published)


Arthurs, R. A., Ismail, M., Prior, C. C., Oganesyan, V. S., Horton, P. N., Coles, S. J., Richards, C. J.

(2016)

Enantiopure Ferrocene-Based Planar-Chiral Iridacycles: Stereospecific Control of Iridium-Centred Chirality,

in Chemistry - A European Journal

22

(9)

pp. 3065-3072

Full Text UEA Repository

(Article)

(Published)


Cassar, D. J., Roghzai, H., Villemin, D., Horton, P. N., Coles, S. J., Richards, C. J.

(2015)

Chirality Control in Planar Chiral Cobalt Oxazoline Palladacycles,

in Organometallics

34

(12)

pp. 2953-2961

Full Text UEA Repository

(Article)

(Published)


Amin, J., Motevalli, M., Richards, C. J.

(2015)

Application of the Nicholas reaction to the synthesis of dicobalt hexacarbonyl complexed diyne ethers,

in Journal of Organometallic Chemistry

776

pp. 43-50

Full Text UEA Repository

(Article)

(Published)


Panchal, K., Amin, J., Roca, F. X., Motevalli, M., Horton, P. N., Coles, S. J., Richards, C. J.

(2015)

Synthesis of racemic palladacycles from 2-ferrocenylphenylphosphines,

in Journal of Organometallic Chemistry

775

pp. 12-19

Full Text UEA Repository

(Article)

(Published)


Cassar, D. J., Ilyashenko, G., Ismail, M., Woods, J., Hughes, D. L., Richards, C. J.

(2013)

Enantioselective Synthesis and Application to the Allylic Imidate Rearrangement of Amine-Coordinated Palladacycle Catalysts of Cobalt Sandwich Complexes,

in Chemistry - A European Journal

19

(52)

pp. 17951-17962

Full Text UEA Repository

(Article)

(Published)


Richards, C., Hassan, J.

(2012)

α-Formylation of α-Substituted Ketones,

in Synlett

2012

(02)

pp. 239-242

Full Text UEA Repository

(Article)

(Published)


Amin, J., Richards, C.

(2012)

Diastereoselective synthesis of half-sandwich chiral-at-metal cobaltacycles by oxidative cyclisation,

in Chemical Communications

48

pp. 10192-10194

Full Text UEA Repository

(Article)

(Published)


Cassar, D., Nagaradja, E., Butler, D., Villemin, D., Richards, C.

(2012)

Regioselective, Stereoselective, and Conformationally Controlled Synthesis of (η4-Tetraarylcyclobutadiene)(η5-carbomethoxycyclopentadienyl)cobalt Metallocenes,

in Organic Letters

14

(3)

pp. 894-897

Full Text UEA Repository

(Article)

(Published)


Dendele, N., Bisaro, F., Gaumont, A., Perrio, S., Richards, C.

(2012)

Synthesis of a [2.2]paracyclophane based planar chiral palladacycle by a highly selective kinetic resolution/C–H activation reaction,

in Chemical Communications

48

(14)

pp. 1991-1993

Full Text UEA Repository

(Article)

(Published)


Gunay, M. E., Hughes, D., Richards, C. J.

(2011)

Diastereoselective Synthesis of Planar Chiral Cobalt Metallocene Based Oxazoline Platinacycles,

in Organometallics

30

(14)

pp. 3901-3904

Full Text UEA Repository

(Article)

(Published)


Spencer, J., Amin, J., Coxhead, P., McGeehan, J., Richards, C. J., Tizzard, G. J., Coles, S. J., Bingham, J. P., Hartley, J. A., Feng, L., Meggers, E., Guille, M.

(2011)

Size Does Matter. Sterically Demanding Metallocene-Substituted 3-Methylidene-Oxindoles Exhibit Poor Kinase Inhibitory Action,

in Organometallics

30

(11)

pp. 3177-3181

Full Text UEA Repository

(Article)

(Published)


Nomura, H., Richards, C. J.

(2010)

Allylic Imidate Rearrangements Catalyzed by Planar Chiral Palladacycles,

in Chemistry - An Asian Journal

5

(8)

pp. 1726-1740

Full Text UEA Repository

(Article)

(Published)


Bergin, E., Hughes, D., Richards, C. J.

(2010)

Application of the Suzuki reaction to the asymmetric desymmetrisation of 1,2-and 1,3-disubstituted bulky cobalt metallocenes,

in Tetrahedron: Asymmetry

21

(11-12)

pp. 1619-1623

Full Text UEA Repository

(Article)

(Published)


Gunay, M. E., Ilyashenko, G., Richards, C. J.

(2010)

Models for the basis of enantioselection in palladium mediated C-H activation reactions,

in Tetrahedron: Asymmetry

21

(23)

pp. 2782-2787

Full Text UEA Repository

(Article)

(Published)


El-Fayyoumy, S., Todd, M. H., Richards, C.

(2009)

Can we measure catalyst efficiency in asymmetric chemical reactions? A theoretical approach,

in Beilstein Journal of Organic Chemistry

5

(8)

pp. 1726-1740

Full Text UEA Repository

(Article)

(Published)


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Key Research Interests

 

Asymmetric organometallic chemistry - synthesis of metallocenes and metallacycles

A key activity in the group is the development of methodology for the stereoselective synthesis of chiral non-racemic organometallic complexes. Previous work has included the synthesis of ferrocene-based ligands (e.g. 1) and pincer metallacycles (e.g. 2). Existing work focuses on combining these themes with metallacycle-based metallocenes and related sandwich complexes containing two metals (e.g. 3). In particular, enantioselective C-H activation is being utilised for the simple one-step step synthesis of additional two-metal compounds (e.g. 4 and 5). The potential of novel reactivity and stereochemical control in these complexes as a consequence of metal-metal interaction is under investigation.

 

 

Asymmetric catalysis and the discovery of new bioactive compounds.

The catalytic potential of the complexes synthesised in the group is explored to enable the straightforward generation of valuable chiral compounds in high enantiomeric excess (e.g. the use of 3 for the multigram synthesis of protected allylic amines 6). The methodologies developed are incorporated into sequentially-catalysed reaction protocols for the synthesis of bioactive compounds for collaborative drug discovery programmes.