A selection of our key publications A selection of our key publications


Steri, V, Ellison, TS, Gontarczyk, AM, Weilbaecher, KN, Schneider, JG, Edwards, DR, Fruttiger, M, Hodivala-Dilke, KM, and Robinson, SD (2013) Acute depletion of endothelial 3-integrin transiently inhibits tumour growth and angiogenesis in mice. Circulation Research, in press
Rose Davidson, Orla Jupp, Rachel de Ferrars, Colin Kay, Kirsty Culley, Rosemary Norton, Clare Driscoll, Tonia Vincent, Simon Donell, Yongping Bao, Ian Clark (2013) Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo. Arthritis & Rheumatism, in press
Culley KL, Hui W, Barter MJ, Davidson RK, Swingler TE, Destrument AP, Scott JL, Donell ST, Fenwick S, Rowan AD, Young DA, Clark IM.  Arthritis Rheum. 2013 Apr 10. doi: 10.1002/art.37965 
Haan N, Goodman T, Najdi-Samiei A, Stratford CM, Rice R, El Agha E, Bellusci S, Hajihosseini MK. (2013) Fgf10-expressing tanycytes add new neurons to the appetite/energy-balance regulating centres of the postnatal and adult hypothalamus. J Neurosci. 33(14):6170-80. doi: 10.1523/JNEUROSCI.2437-12.2013 
The microtubule end-binding protein EB2 is a central regulator of microtubule reorganisation in apico-basal epithelial differentiation. Deborah A Goldspink, Jonathan R Gadsby, Gemma Bellett, Jennifer Keynton, Benjamin J Tyrrell, Elizabeth K Lund, Penny P Powell, Paul Thomas and Mette M Mogensen. J Cell Science in press
Reynolds A, Wharton N, Parris A, Mitchell E, Sobolewski A, Kam C, Bigwood L, El Hadi A, Munsterberg A, Lewis M, Speakman C, Stebbings W, Wharton R, Sargen K, Tighe R, Jamieson C, Hernon J, Kapur S, Oue N, Yasui W and Williams M (2013). Canonical Wnt signals combined with suppressed TGF/BMP pathways promote renewal of the native human colonic epithelium. Gut (in press) 


Sivaramakrishnan, V, Bidula, S, Campwala H, Katikaneni, D and Fountain, SJ (2012).  Constitutive lysosome exocytosis releases ATP and engages P2Y receptors in human monocytes.  Journal of Cell Science,125. Pp 4567 – 75 
Katarzyna Goljanek-Whysall, K., Pais, H., Rathjen, T., Sweetman, D.,  Dalmay, T. and  Münsterberg, A. (2012) Regulation of multiple target genes by miR-1/miR-206 is pivotal for C2C12 myogenesis, Journal of Cell Science 125, pp. 3590–3600 
Baker, N, Sharpe, P, Culley, K, Otero, M, Bevan, D, Newham, P, Barker, W, Clements, KM, Langham, CJ, Goldring, MB and Gavrilovic, J (2012)Dual regulation of metalloproteinase expression in chondrocytes by WISP3/CCN6. Arthritis & Rheumatism. 64(7):2289-99. doi: 10.1002/art.34411 


Goljanek-Whysall, K, Sweetman, D, Abu-Elmagd, M, Chapnik, E, Dalmay, T, Hornstein, E and Munsterberg, A (2011) MicroRNA regulation of the paired-box transcription factor Pax3 confers robustness to developmental timing of myogenesis. Proceedings of the National Academy of Sciences, 108 (29). pp. 11936-11941. ISSN 0027-8424 
White, RM, Cech, J, Ratanasirintrawoot, S, Lin, CY, Rahl, PB, Burke, CJ, Langdon, E, Tomlinson, ML, Mosher, J, Kaufman, C, Chen, F, Long, HK, Kramer, M, Datta, S, Neuberg, D, Granter, S,Young, RA, Morrison, S, Wheeler, GN and Zon, LI (2011) DHODH modulates transcriptional elongation in the neural crest and melanoma. Nature, 471 (7339). pp. 518-522. ISSN 0028-0836 
Swingler, TE, Wheeler, G, Carmont, V, Elliott, HR, Barter, MJ, Abu-Elmagd, M, Donell, ST, Boot-Handford, RP, Hajihosseini, MK,Munsterberg, A, Dalmay, T, Young, DA and Clark, IM (2011) The expression and function of microRNAs in chondrogenesis and osteoarthritis. Arthritis & Rheumatism 
Soond, SM and Chantry, A (2011) Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT. Oncogene, 30. pp. 2451-2462. ISSN 0950-9232 
Bass, R, Wagstaff, L, Ravenhill, L and Ellis, V (2009) Binding of Extracellular Maspin to 1 Integrins Inhibits Vascular Smooth Muscle Cell Migration. Journal of Biological Chemistry, 284 (40). pp. 27712-27720. ISSN 0021-9258 
Grocott, T, Johnson, S, Bailey, AP and Streit, A (2011) Neural crest cells organize the eye via TGF-β and canonical Wnt signalling. Nature Communications, 2. p. 265. ISSN 2041-1723 
Bouter, A, Gounou, C, Bérat, R, Tan, S, Gallois, B, Granier, T, d'Estaintot, BL, Pöschl, E, Brachvogel, B and Brisson, AR (2011) Annexin-A5 assembled into two-dimensional arrays promotes cell membrane repair. Nature Communications, 2. p. 274. ISSN 2041-1723 


Cooley LS, Handsley MM, Zhou Z, Lafleur MA, Pennington CJ, Thompson, EW, Pöschl E and Edwards DR. (2010 ) Reversible trans-differentiation of blood vascular endothelial cells to a lymphatic-like phenotype in vitro. J. Cell Sci. 123: 3808-3816.
Atkinson, J.M., Falconer, R.A., Edwards, D.R., Pennington, C.J., Siller, C.S., Shnyder, S.D., Bibby, M.C., Patterson, L.H., Loadman, P.M. and Gill, J.H. (2010) Development of a Novel Tumor-Targeted Vascular Disrupting Agent Activated by Membrane-Type Matrix Metalloproteinases. Cancer Research, 70 (17). pp. 6902-6912. ISSN 0008-5472


Tomlinson, M.L., Guan, P., Morris, R.J., Fidock, M., Rejzek, M., Garcia-Morales, C., Field, R.A. and Wheeler, G.N. (2009) A chemical genomic approach identifies matrix metalloptroteinases as playing an essential and specific role in Xenopus melanophore migration. Chemistry and Biology, 16 (1). pp. 93-104 
Maretzky, T., Le Gall, S.M., Worpenberg, S., Eder, J., Overall, C., Huang, X-Y., Poghosyan, Z., Edwards, D.R. and Blobel, C.P. (2009) Src stimulates FGFR2 shedding by an ADAM15 splice variant linked to breast cancer. Cancer Research, 69. pp. 4573-4576.
Overly long centrioles and defective cell division upon excess of the SAS-4-related protein CPAP. Kohlmaier G, Loncarek J, Meng X, McEwen BF, Mogensen MM, Spektor A, Dynlacht BD, Khodjakov A, Gönczy P. Curr Biol. 2009 Jun 23;19(12):1012-8 (4*)
Reynolds, AR, Hart, IT, Watson, AR, Welti, JC, Silva, RG, Robinson, SD, Da Violante, G, Gourlaouen, M, Salih, M, Jones, MC, Jones, DT,Saunders, G, Kostourou, V, Perron-Sierra, F, Norman, JC, Tucker, GC and Hodivala-Dilke, KM (2009) Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors. Nature Medicine, 15 (4). pp. 392-400. ISSN 1078-8956 (4*)


Yue, Q., Wagstaff, L., Yang, X., Weijer, C. and Munsterberg, A. (2008) Wnt3a mediated chemorepulsion controls movement patterns of cardiac progenitors and requires RhoA function. Development, 135. pp. 1029-1037. 
Clark, J, Attard, G, Jhavar, S, Flohr, P, Reid, A, De-Bono, J and Cooper, CS (2008) Complex patterns of ETS gene alteration arise during cancer development in the human prostate. Oncogene, 27. pp. 1993-2003. 
Attard, G, Clark, J, Ambroisine, L, Fisher, G, Kovacs, G, Flohr, P and Cooper, CS (2008) Duplication of the fusion of TMPRSS2 to ERG sequences identifies fatal human prostate cancer. Oncogene, 27. pp. 253-263. 
Eeles, and Cooper, CS (2008) Multiple newly identified loci associated with prostate cancer susceptibility. Nature Genetics, 40 (3). pp. 316-321. 
Gutierrez-Fernandez, A, Fueyo, A, Folgueras, AR, Garabaya, C, Pennington, CJ, Pilgrim, S, Edwards, DR, Holliday, DL, Jones, JL, Span, PN, Sweep, FCGJ, Puente, XS and Lopez-Otin, C (2008) Matrix Metalloproteinase-8 functions as a metastasis suppressor through modulation of tumour cell adhesion and invasion. Cancer Research, 68. pp. 2755-2763.
Wang, H., Chang, L., Brixius, K., Wickstrom, S.A., Montanez, E., Thievessen, I., Schwander, M., Muller, U., Bloch, W., Mayer, U. and Fassler, R. (2008) Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage. Journal of Cell Biology, 180. pp. 1037-1049.