Career History

  • 1991 to 1994 University of Portsmouth. BSc (Hons) Biology. First Class
  • 1994 to 1998 University of Southampton. Ph.D
  • 1998 to 2001 University of East Anglia. Senior Research Associate
  • 2001 to 2005 John Innes Centre. Project Scientist
  • 2006 to 2010 University of East Anglia. RCUK Fellow
  • 2011 to 2012 Lecturer
  • 2012 to 2013 Senior Lecturer
  • 2013 to 2016 Reader
  • 2016 onwards Professor of Molecular Microbiology

 


ResearcherID


http://www.researcherid.com/rid/D-1923-2009

Academic Background

I moved to UEA as an Research Councils UK Fellow in January 2006 after a four year postdoc on Streptomyces cell signalling in Mark Buttner's laboratory at the John Innes Centre. I was appointed Professor of Molecular Microbiology in April 2016. 

All Publications

<- Page 1 of 3 ->

Volbeda, A., Dodd, E. L., Darnault, C., Crack, J. C., Renoux, O., Hutchings, M. I., Le Brun, N. E., Fontecilla-Camps, J. C.

(2017)

Crystal structures of the NO sensor NsrR reveal how its iron-sulfur cluster modulates DNA binding,

in Nature Communications

8

article no. 15052

Full Text UEA Repository

(Article)

(Published)


Qin, Z., Munnoch, J. T., Devine, R., Holmes, N. A., Seipke, R. F., Wilkinson, K. A., Wilkinson, B., Hutchings, M. I.

(2017)

Formicamycins, antibacterial polyketides produced by Streptomyces formicae isolated from African Tetraponera plant-ants,

in Chemical Science

8

(4)

pp. 3218-3227

Full Text UEA Repository

(Article)

(Published)


Crack, J., Hutchings, M., Thomson, A., Le Brun, N.

(2016)

Biochemical properties of Paracoccus denitrificans FnrP: Reactions with molecular oxygen and nitric oxide,

in JBIC Journal of Biological Inorganic Chemistry

21

(1)

pp. 71-82

Full Text UEA Repository

(Article)

(Published)


Crack, J., Svistunenko, D. A., Munnoch, J., Thomson, A., Hutchings, M., Le Brun, N.

(2016)

Differentiated, promoter-specific response of [4Fe-4S] NsrR DNA-binding to reaction with nitric oxide,

in Journal of Biological Chemistry

291

pp. 8663-8672

Full Text UEA Repository

(Article)

(Published)


Munnoch, J. T., Widdick, D. A., Chandra, G., Sutcliffe, I. C., Palmer, T., Hutchings, M. I.

(2016)

Cosmid based mutagenesis causes genetic instability in Streptomyces coelicolor, as shown by targeting of the lipoprotein signal peptidase gene,

in Scientific Reports

6

article no. 29495

Full Text UEA Repository

(Article)

(Published)


Munnoch, J. T., Pellicer Martinez, M. T., Svistunenko, D. A., Crack, J. C., Le Brun, N. E., Hutchings, M. I.

(2016)

Characterization of a putative NsrR homologue in Streptomyces venezuelae reveals a new member of the Rrf2 superfamily,

in Scientific Reports

6

article no. 31597

Full Text UEA Repository

(Article)

(Published)


Serrano, P. N., Wang, H., Crack, J. C., Prior, C., Hutchings, M. I., Thomson, A. J., Kamali, S., Yoda, Y., Zhao, J., Hu, M. Y., Alp, E. E., Oganesyan, V. S., Le Brun, N. E., Cramer, S. P.

(2016)

Nitrosylation of Nitric-Oxide-Sensing Regulatory Proteins Containing [4Fe-4S] Clusters Gives Rise to Multiple Iron-Nitrosyl Complexes,

in Angewandte Chemie International Edition

55

(47)

Full Text UEA Repository

(Article)

(Published)


Holmes, N. A., Innocent, T. M., Heine, D., Al-Bassam, M., Worsley, S. F., Trottman, F., Patrick, E. H., Yu, D. W., Murrell, J. C., Schiott, M., Wilkinson, B., Boomsma, J. J., Hutchings, M. I.

(2016)

Genome analysis of two Pseudonocardia phylotypes associated with Acromyrmex leafcutter ants reveals their biosynthetic potential,

in Frontiers in Microbiology

7

article no. 2073

Full Text UEA Repository

(Article)

(Published)


Crack, J., Munnoch, J. T., Dodd, E., Knowles, F., Al-Bassam, M., Kamali, S., Holland, A., Cramer, S., Hamilton, C., Johnson, M., Thomson, A., Hutchings, M., Le Brun, N.

(2015)

NsrR from Streptomyces coelicolor Is a Nitric Oxide-sensing [4Fe-4S] Cluster Protein with a Specialized Regulatory Function,

in The Journal of Biological Chemistry

290

pp. 12689-12704

Full Text UEA Repository

(Article)

(Published)


Seipke, R. F., Patrick, E., Hutchings, M. I., Hutchings, M.

(2014)

Regulation of antimycin biosynthesis by the orphan ECF RNA polymerase sigma factor σ (AntA.),

in PeerJ

2

pp. e253

Full Text UEA Repository

(Article)

(Published)


Gao, H., Grüschow, S., Barke, J., Seipke, R. F., Hill, L. M., Orivel, J., Yu, D. W., Hutchings, M., Goss, R. J. M.

(2014)

Filipins: the first antifungal “weed killers” identified from bacteria isolated from the trap-ant,

in RSC Advances

4

(100)

pp. 57267-57270

Full Text UEA Repository

(Article)

(Published)


Clark, L., Seipke, R., Prieto, P., Willemse, J., van Wezel, G., Hutchings, M., Hoskisson, P.

(2013)

Mammalian cell entry genes in Streptomyces may provide clues to the evolution of bacterial virulence,

in Scientific Reports

3

article no. 1109

Full Text UEA Repository

(Article)

(Published)


Seipke, R. F., Hutchings, M. I.

(2013)

The regulation and biosynthesis of antimycins,

in Beilstein Journal of Organic Chemistry

9

pp. 2556-2563

Full Text UEA Repository

(Article)

(Published)


Seipke, R. F., Barke, J., Heavens, D., Yu, D. W., Hutchings, M. I.

(2013)

Analysis of the bacterial communities associated with two ant-plant symbioses,

in MicrobiologyOpen

2

(2)

pp. 276-283

Full Text UEA Repository

(Article)

(Published)


Crack, J., Green, J., Hutchings, M., Thomson, A., Le Brun, N.

(2012)

Bacterial iron-sulfur regulatory proteins as biological sensor-switches,

in Antioxidants & Redox Signaling

17

pp. 1215-1231

Full Text UEA Repository

(Article)

(Published)


Seipke, R., Barke, J., Ruiz-Gonzalez, M., Orivel, J., Yu, D., Hutchings, M.

(2012)

Fungus-growing Allomerus ants are associated with antibiotic-producing Actinobacteria,

in Antonie van Leeuwenhoek

101

pp. 443-447

Full Text UEA Repository

(Article)

(Published)


Willemse, J., Ruban-osmialowska, B., Widdick, D., Celler, K., Hutchings, M. I., Van Wezel, G. P., Palmer, T.

(2012)

Dynamic Localization of Tat Protein Transport Machinery Components in Streptomyces coelicolor,

in Journal of Bacteriology

194

(22)

pp. 6272-6281

Full Text UEA Repository

(Article)

(Published)


Sutcliffe, I. C., Harrington, D. J., Hutchings, M. I.

(2012)

A phylum level analysis reveals lipoprotein biosynthesis to be a fundamental property of bacteria,

in Protein & Cell

3

(3)

pp. 163-170

Full Text UEA Repository

(Article)

(Published)


Seipke, R., Gruschow, S., Goss, R., Hutchings, M.

(2012)

Isolating antifungals from fungus-growing ant symbionts using a genome-guided chemistry approach,

in Methods in Enzymology

517

pp. 47-70

Full Text UEA Repository

(Article)

(Published)


Moore, J., Bradshaw, E., Seipke, R., Hutchings, M., McArthur (JIC), M.

(2012)

Use and discovery of chemical elicitors that stimulate biosynthetic gene clusters in Streptomyces bacteria,

in Methods in Enzymology

517

pp. 367-385

Full Text UEA Repository

(Article)

(Published)


<- Page 1 of 3 ->

Key Research Interests

My research interests include:

  • Analysis and rewiring of conserved and essential signal tranduction pathways in Streptomyces bacteria to activate antibiotic production.
  • Developing synthetic biology tools to unlock and discover new antibiotics in filamentous actinomycetes.
  • Understanding how nitric oxide gas acts as a signal to trigger cell division and antibiotic production in Streptomyces species.
  • Understanding the formation or protective symbioses between plant roots and Streptomyces bacteria.
  • Understanding microbiome formation using leafcutter ants as a model.  

Life in our research group 

We are bacteriologists and we use a range of approaches to understand how antibiotic-prioducing actinomycete bacteria survive in complex environments, most notably the soil and on (and inside) eukaryotic host organisms. A big focus of our research is to discover novel natural products from these bacteria which can be developed as antibiotics for clinical use but we are also interested in how these antibiotics are used in nature (by the bacteria and by host like plants and insects). We use genome and metagenome sequencing, molecular genetics, protein purification and biochemistry, immunochemistry, microscopy, spectroscopy and LC MS. We have well equipped lab space in the School of Biological Sciences which is a vibrant, enjoyable and stimulating environment with a mix of national and international students and postdocs. We also have strong links and collaborations with scientists at our partner institutes on the Norwich Research Park, the John Innes Centre and the Genome Analysis Centre. Research is shared at regular lab meetings and theme seminars and there are many opportunities to attend national and international conferences to present data.


PhD Positions

Click here for current PhD opportunities in Biological Sciences. But feel free to email me to discuss projects outside these areas and alternative sources of funding.


Postdocs & Fellows

I welcome enquiries from motivated postdocs who are interested in applying for their own funding to come and work in my lab.

Video

Teaching Interests

I am passionate about microbiology and teach mostly on third year undergraduate and MSc microbiology and biotechnology modules. I also supervise undergraduate and postgraduate research projects and PhD students in my research laboratory.

Teaching Activities

  • BIO-3C6Y
  • BIO-3C10
  • BIO-3C28
  • BIO-3C41
  • BIO-3C57
  • M105 (MSc in Biotechnology)

Professional Activities

  • Member of the BBSRC Pool of Experts (January 2014 onwards)
  • Associate Dean for Enterprise and Engagement, Science Faculty (January 2014 onwards)
  • Member of the Peer J Editorial Board (2013 onwards)
  • Fellow of the Higher Education Academy
  • Two invited seminars at the Society for General Microbiology Spring conference (2013)
  • Invited seminar at the Society for Applied Microbiology summer conference (2013)
  • Invited seminar at the Gordon Research Conference on Bacterial Cell Surfaces (2012)
  • Editor Microbiology Today (2006-2009)
  • Member of Council for Society for General Microbiology (2006-2009)

Administrative Posts

Associate Dean for Enterprise, Science Faculty