Career History
- Senior Lecturer in Cell Biology, University of East Anglia (2002-present; full-time since 2014)
- Lecturer in Cell Biology (75% time), University of East Anglia (1997-2002)
- Group Leader (60% time) Strangeways Research Laboratory (1994-1997)
- Post-doctoral Associate (50% time) , Strangeways Research Laboratory, Cambridge (1993-1994)
- One-year career break after birth of first child (1992-1993)
- Post-doctoral Fellow, University College London (1989-1992)
- Royal Society and EMBO Post-doctoral Fellow Ecole Normale Superieure, Paris, France(1987-1989)
- Ph.D. - Strangeways Research Laboratory, Cambridge (1987)
- B.Sc. - Cell Biology, University College London (1978)
All Publications
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(2018)
N-3 fatty acids combined with flavan-3-ols prevent steatosis and liver injury in a murine model of NAFLD,
in Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
1864
(1)
pp. 69-78
Full Text UEA Repository(Article)
(Published)
(2017)
Imaging of compartmentalised intracellular nitric oxide, induced during bacterial phagocytosis, using a metalloprotein–gold nanoparticle conjugate,
in Analyst
142
(21)
pp. 4099-4105
Full Text UEA Repository(Article)
(Published)
(2016)
Chondrocyte responses to neurovascular peptides, cytokines, and a 3D environment: focus on ADAMs,
in Metalloproteinases in Medicine
3
pp. 63-74
Full Text UEA Repository(Article)
(Published)
(2015)
Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs-15: ADAMTS-15 Inhibits Breast Cancer Cell Migration,
in International Journal of Cancer
136
(4)
pp. E14–E26
Full Text UEA Repository(Article)
(Published)
(2013)
Macrophage Migration and Invasion Is Regulated by MMP10 Expression,
in PLoS ONE
8
(5)
article no. e63555
Full Text UEA Repository(Article)
(Published)
(2012)
Dual regulation of metalloproteinase expression in chondrocytes by Wnt-1–inducible signaling pathway protein 3/CCN6,
in Arthritis & Rheumatism
64
(7)
pp. 2289–2299
Full Text UEA Repository(Article)
(Published)
(2008)
Spectroscopic studies of 1,2-diaminoanthraquinone (DAQ) as a fluorescent probe for the imaging of nitric oxide in live cells,
in Photochemical & Photobiological Sciences
7
(1)
pp. 126-130
Full Text UEA Repository(Article)
(Published)
(2008)
Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma,
in Molecular Cancer Research
6
pp. 383-394
Full Text UEA Repository(Article)
(Published)
(2007)
Low density lipoprotein from patients with Type 2 diabetes increases expression of monocyte matrix metalloproteinase and ADAM metalloproteinase genes,
in Cardiovascular Diabetology
6
(1)
pp. 21
Full Text UEA Repository(Article)
(Published)
(2006)
Monocyte matrix and ADAM metalloproteinase expression in type 2 diabetes after aspirin therapy.,
in Diabetes Research and Clinical Practice
71
pp. 45-51
Full Text UEA Repository(Article)
(Published)
(2006)
Intracellular Photodynamic Therapy with Photosensitizer-Nanoparticle Conjugates: Cancer Therapy Using a 'Trojan Horse',
in Photochemical & Photobiological Sciences
5
(8)
pp. 727-734
Full Text UEA Repository(Article)
(Published)
(2005)
Synthetic Macrocyclic Peptidomimetics as Tunable pH Probes for the Fluorescence Imaging of Acidic Organelles in Live Cells,
in Angewandte Chemie-International Edition
44
(40)
pp. 6504-6508
Full Text UEA Repository(Article)
(Published)
(2005)
Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3.,
in Cardiovascular Research
67
(1)
pp. 39-49
Full Text UEA Repository(Article)
(Published)
(2004)
Matrix metalloproteinase genes inXenopus development,
in Developmental Dynamics
231
(1)
pp. 214-220
Full Text UEA Repository(Article)
(Published)
(2004)
Plasma matrix metalloproteinases, low density lipoprotein oxidisability and soluble adhesion molecules after a glucose load in Type 2 diabetes,
in Cardiovascular Diabetology
3
pp. 7
Full Text UEA Repository(Article)
(Published)
(2003)
Monocyte matrix metalloproteinase production in Type 2 diabetes and controls - a cross sectional study.,
in Cardiovascular Diabetology
2
pp. 1-4
Full Text UEA Repository(Article)
(Published)
(2003)
Extracellular matrix and matrix metalloproteinases in sciatic nerve.,
in Journal of Neuroscience Research
74
(3)
pp. 417-429
Full Text UEA Repository(Article)
(Published)
(2003)
Metalloproteinase expression in PMA stimulated THP-1 cells: effects of peroxisome proliferator-activated receptor-y (PPARy) agonists and 9-cis-retionic acid.,
in Journal of Biological Chemistry
278
(51)
pp. 51340-51346
Full Text UEA Repository(Article)
(Published)
(2002)
Role of newly synthesized fibronectin in vascular smooth muscle cell migration on matrix-metalloproteinase-degraded collagen.,
in Biochemical Society Transactions
30
pp. 102-111
Full Text UEA Repository(Article)
(Published)
(2000)
Cellular mechanisms for focal proteolysis and the regulation of the microenvironment,
in Fibrinolysis and Proteolysis
14
(2-3)
pp. 165-174
Full Text UEA Repository(Article)
(Published)
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Key Research Interests
Our interests lie in cell-cell and cell-matrix interactions in health and disease, with an emphasis on inflammation. We have some focus on how metalloproteinases of the MMP, ADAM and ADAMTS families may modulate these interactions.
Current Research Projects
- Mechanisms underpinning breakdown of the blood brain barrier in Multiple sclerosis (collaboration with Martin Lee, NNUH and Mohammad Hajihosseini, Mette Mogensen and Matt Gage, BIO.)
- Norwich Skin Platform: exploring the effects of plant extracts on skin biology in health and disease (collaboration with Cathie Martin, JIC, Jeremy Turner, NNUH, Marc Moncrieff, NNUH).
- Role of WT1 in cell migration (collaboration with Nick Hastie, MRC HGU Edinburgh)
- Adipose tissue inflammation (collaborative project with Matt Fenech and Jeremy Turner, MED and NNUH)
Life in our research group
We are cell biologists studying several key disease processes. Using in vivo and in vitro approaches and state-of-the-art imaging techniques we work to unravel the complex mechanisms involved in inflammation in health and disease. We also have interests in modelling in vivo disease scenarios by growing cells in a 3-dimensional matrix and at appropriate oxygen tension. Our work benefits from collaborations within BIO and with colleagues across the Norwich Research Park and across the UK, Europe and the USA and in pharmaceutical companies.
PhD Positions
Click here for current PhD opportunities in Biological Sciences. But feel free to email me to discuss projects outside these areas and alternative sources of funding.
Postdocs & Fellows
I am always happy to discuss possibilities for postdoctoral work and collaborations.
Teaching Interests
- I teach Cell Biology in second and third year modules and on Biomedicine modules and Masters Medical Biotechnology module
External Activities and Indicators of Esteem
- Editorial Board Member "Metalloproteinases in Medicine"
- Co-organiser "Metalloproteinases: beginnings, present and future" Oxford, August 2016
- British Society of Matrix Biology Committee Member 2006-2010.
- Organiser of BSMB meeting at UEA September 6th/7th 2010 “Inflammation Meets Matrix Biology”.
Administrative Posts
- Module Organiser for second year Cell Biology (5005B)
- Previously:
- Director of Enterprise for School of Biological Sciences, UEA
- Director of Postgraduate Research, School of Biological Sciences, UEA