Career History

  • Senior Lecturer, University of East Anglia (2008-present)
  • The Humane Research Trust Lecturer, University of East Anglia (2002-2008)
  • Senior Research Associate - University of East Anglia (1997-2002)
  • PhD - University of East Anglia (1997)
  • BSc - Pharmacology, University of Portsmouth (1993)

All Publications

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Liu, H., Smith, A. J. O., Lott, M. C., Bao, Y., Bowater, R. P., Reddan, J. R., Wormstone, I. M.

(2013)

Sulforaphane Can Protect Lens Cells Against Oxidative Stress: Implications for Cataract Prevention

in Investigative Ophthalmology & Visual Science

54.

pp. 5236-5248

Full Text UEA Repository

(Article)


Fang, C., Illingworth, C. D., Qian, L., Wormstone, I. M.

(2013)

Serum Deprivation Can Suppress Receptor-Mediated Calcium Signaling in Pterygial-Derived Fibroblasts

in Investigative Ophthalmology & Visual Science

54.

pp. 4563-4570

Full Text UEA Repository

(Article)


Dawes, L. J., Duncan, G., Wormstone, I. M., Cells, Cultured, Lens, Crystalline

(2013)

Age-related differences in signaling efficiency of human lens cells underpin differential wound healing response rates following cataract surgery

in Investigative Ophthalmology & Visual Science

54.

pp. 333-42

Full Text UEA Repository

(Article)


Dawes, L., Illingworth, C., Wormstone, I.

(2012)

A fully human in vitro capsular bag model to permit intraocular lens evaluation

in Ophthalmology and Visual Sciences

53.

pp. 23-29

Full Text UEA Repository

(Article)


Eldred, J., Hodgkinson, L., Dawes, L., Reddan, J., Edwards, D., Wormstone, I.

(2012)

MMP2 Activity is Critical for TGF 2-Induced Matrix Contraction--Implications for Fibrosis

in Investigative Ophthalmology & Visual Science

53.

pp. 4085-4098

Full Text UEA Repository

(Article)


Rhodes, J., Lott, M., Russell, S., Moulton, V., Sanderson, J., Wormstone, I., Broadway, D.

(2012)

Activation of the innate immune response and interferon signalling in myotonic dystrophy type 1 and type 2 cataracts

in Human Molecular Genetics

21.

pp. 852-862

Full Text UEA Repository

(Article)


Wang, L., Eldred, J., Smith, A., Bowater, R., Wormstone, M., Sidaway, P., Sanderson, J., Reddan, J.

(2012)

Sigma 1 receptor stimulation protects against oxidative damage through suppression of the ER stress responses in the human lens

in Mechanisms of Ageing and Development

133.

pp. 665-674

Full Text UEA Repository

(Article)


Eldred, J., Dawes, L., Wormstone, I.

(2011)

The lens as a model for fibrotic disease

in Philosophical Transactions of the Royal Society B: Biological Sciences

366.

pp. 1301-1319

Full Text UEA Repository

(Article)


Hodgkinson, L., Wang, L., Duncan, G., Edwards, D., Wormstone, I.

(2010)

ADAM and ADAMTS gene expression in native and wound healing human lens epithelial cells

in Molecular Vision

16.

pp. 2765-2776

UEA Repository

(Article)


Wormstone, I.

(2010)

Posterior Capsule Opacification

In: Encyclopedia of the Eye.

Academic Press

pp. 469-475

ISBN 9780123742032

UEA Repository

(Chapter)


Rhodes, J., Russell, S., Illingworth, C., Duncan, G., Wormstone, I.

(2009)

Regional Differences in Store-Operated Ca2+ Entry in the Epithelium of the Intact Human Lens

in Investigative Ophthalmology & Visual Science

50.

pp. 4330-4336

Full Text UEA Repository

(Article)


Dawes, L., Sleeman, M. A., Anderson, I. K., Reddan, J. R., Wormstone, M.

(2009)

TGF /Smad4-Dependent and -Independent Regulation of Human Lens Epithelial Cells

in Investigative Ophthalmology & Visual Science

50.

pp. 5318-5327

Full Text UEA Repository

(Article)


Wormstone, M., Wang, L., Liu, C. S.

(2009)

Posterior capsule opacification

in Experimental Eye Research

88.

pp. 257-269

Full Text UEA Repository

(Article)


Dawes, L., Eldred, J., Anderson, I., Sleeman, M., Reddan, J., Duncan, G., Wormstone, I.

(2008)

TGF -Induced Contraction Is Not Promoted by Fibronectin-Fibronectin Receptor Interaction, or SMA Expression

in Investigative Ophthalmology & Visual Science

49.

pp. 650-661

Full Text UEA Repository

(Article)


Dawes, L., Ellliott, R., Reddan, J., Wormstone, Y., Wormstone, I.

(2007)

Oligonucleotide regulated gene microarray analysis of human lens epithelial cells: TGF expresion

in Molecular Vision

13.

pp. 1181-1197

UEA Repository

(Article)


Dawes, L., Angell, H., Sleeman, M., Reddan, J., Wormstone, I.

(2007)

TGFbeta isoform dependent Smad2/3 kinetics in human lens epithelial cells: A Cellomics analysis.

in Experimental Eye Research

UEA Repository

(Article)


Duncan, G., Wang, L., Neilson, G., Wormstone, I.

(2007)

Lens cell survival after exposure to stress in the closed capsular bag.

in Investigative Ophthalmology and Visual Science

48.

pp. 2701-2707

Full Text UEA Repository

(Article)


Hodgkinson, L., Duncan, G., Wang, L., Pennington, C., Edwards, D., Wormstone, I.

(2007)

MMP and TIMP expression in quiescent, dividing and differentiating human lens cells

in Investigative Ophthalmology and Visual Science

48.

pp. 4192-4199

Full Text UEA Repository

(Article)


Zhang, H., Duncan, G., Wang, L., Liu, P., Cui, H., Reddan, J., Yang, B., Wormstone, M.

(2007)

Arsenic trioxide initiates ER stress responses, perturbs calcium signalling and promotes apoptosis in human lens epithelial cells☆

in Experimental Eye Research

85.

pp. 825-835

Full Text UEA Repository

(Article)


Grocott, T., Frost, V., Maillard, M., Johansen, T., Wheeler, G. N., Dawes, L. J., Wormstone, I. M., Chantry, A.

(2007)

The MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoter

in Nucleic Acids Research

35.

pp. 890-901

Full Text UEA Repository

(Article)


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Key Research Interests

I am a biomedical scientist with primary interests in the use of human tissue to study human eye disease. In particular, I am interested in wound-healing events that follow cataract surgery, which lead to a secondary visual loss known as posterior capsule opacification (PCO). Through the use of human tissue the laboratory aims to further our understanding of the cell and molecular mechanisms underpinning PCO and identify novel targets for future therapeutic development.

Video

Current Research Projects

  • Investigation of TGFß signalling involvement in matrix contraction and cell transdifferentiation
  • Gene expression and functional analysis of ocular cells
  • Development of human disease models to serve as pre-clinical evaluation tools
  • Optimise novel drug delivery mechanisms to prevent PCO

 

Life in our research group

The laboratory employs human ocular cell and tissue culture models as experimental systems to understand the human condition and develop appropriate therapies. The laboratory is equipped with dedicated state-of-the-art analysis tools that facilitate the research programme. There is a good blend of experienced post-doctoral scientists and enthusiastic students eager to learn. The group has international standing within our area of expertise and laboratory members get the opportunity to present their work across the world at meetings in North America, Asia and Europe. This experience is valuable to the development of individuals and the team as a whole.

PhD Positions 

Click here for current PhD opportunities in Biological Sciences. But feel free to email me to discuss projects outside these areas and alternative sources of funding.

Postdocs & Fellows

I am always happy to discuss possibilities for post-doctoral work and collaborations and Fellowship schemes with me acting as a sponsor.

Teaching Interests

  • Foundations for Physiology (BIO-1A58)
  • Skills for Biologists (BIO-1A4Y)
  • Introduction to Biomedicine (BIO-1A57)
  • Cell Biology (BIO-2B06)
  • Human Physiology (BIO-2B05)
  • Advanced Cell Biology (BIO-3C18)
  • Research Project (BIO-3C32)

External Activities and Indicators of Esteem

  • Industrial collaborations: Cambridge Antibody Technology - Transforming growth factor beta inhibition; Milvella Ltd - drug delivery; Biologie Servier
  • Review for: Investigative Ophthalmology and Visual Sciences; Experimental Eye Research; British Journal of Ophthalmology; American Journal of Pathology; Molecular Vision
  • 1995 & 1996 AER-Chauvin Prize. Awarded for the best abstract by a presenting author, under 35, at the annual JERMOV meeting. In receiving these awards I became the only person ever to win the prize twice, and in successive years.
  • 2008 Elected Fellow of the Royal Society of Medicine
  • 2009 Honorary Chair of Harbin Medical University
  • Co-inventor on three international patents. Use of calcium intracellular store inactivators and formulations thereof as cell growth inhibitors (#95 16458.8); Treatment of fibrotic eye disorders US 61/095547; Treatment of fibrotic eye disorders using an MMP2 inhibitor US 61/095554

Administrative Posts

  • Human Physiology (BIO-2B05) Module Organiser.
  • Since January 2003-2005, I organised weekly seminars for the Cell Sector.
  • I was a member of the Quinquennial review committee for the Biological Sciences degree course.
  • Since August 2006, I have been Deputy Head of Teaching and Learning (BIO)
  • I am currently a member of working group for the Natural Sciences degree programme.