- Senior Lecturer, University of East Anglia (2008-present)
- The Humane Research Trust Lecturer, University of East Anglia (2002-2008)
- Senior Research Associate - University of East Anglia (1997-2002)
- PhD - University of East Anglia (1997)
- BSc - Pharmacology, University of Portsmouth (1993)
Key Research Interests
I am a biomedical scientist with primary interests in the use of human tissue to study human eye disease. In particular, I am interested in wound-healing events that follow cataract surgery, which lead to a secondary visual loss known as posterior capsule opacification (PCO). Through the use of human tissue the laboratory aims to further our understanding of the cell and molecular mechanisms underpinning PCO and identify novel targets for future therapeutic development.
Current Research Projects
- Investigation of TGFß signalling involvement in matrix contraction and cell transdifferentiation
- Gene expression and functional analysis of ocular cells
- Development of human disease models to serve as pre-clinical evaluation tools
- Optimise novel drug delivery mechanisms to prevent PCO
Life in our research group
The laboratory employs human ocular cell and tissue culture models as experimental systems to understand the human condition and develop appropriate therapies. The laboratory is equipped with dedicated state-of-the-art analysis tools that facilitate the research programme. There is a good blend of experienced post-doctoral scientists and enthusiastic students eager to learn. The group has international standing within our area of expertise and laboratory members get the opportunity to present their work across the world at meetings in North America, Asia and Europe. This experience is valuable to the development of individuals and the team as a whole.
Postdocs & Fellows
I am always happy to discuss possibilities for post-doctoral work and collaborations and Fellowship schemes with me acting as a sponsor.
- Foundations for Physiology (BIO-1A58)
- Skills for Biologists (BIO-1A4Y)
- Introduction to Biomedicine (BIO-1A57)
- Cell Biology (BIO-2B06)
- Human Physiology (BIO-2B05)
- Advanced Cell Biology (BIO-3C18)
- Research Project (BIO-3C32)
External Activities and Indicators of Esteem
- Industrial collaborations: Cambridge Antibody Technology - Transforming growth factor beta inhibition; Milvella Ltd - drug delivery; Biologie Servier
- Review for: Investigative Ophthalmology and Visual Sciences; Experimental Eye Research; British Journal of Ophthalmology; American Journal of Pathology; Molecular Vision
- 1995 & 1996 AER-Chauvin Prize. Awarded for the best abstract by a presenting author, under 35, at the annual JERMOV meeting. In receiving these awards I became the only person ever to win the prize twice, and in successive years.
- 2008 Elected Fellow of the Royal Society of Medicine
- 2009 Honorary Chair of Harbin Medical University
- Co-inventor on three international patents. Use of calcium intracellular store inactivators and formulations thereof as cell growth inhibitors (#95 16458.8); Treatment of fibrotic eye disorders US 61/095547; Treatment of fibrotic eye disorders using an MMP2 inhibitor US 61/095554
- Human Physiology (BIO-2B05) Module Organiser.
- Since January 2003-2005, I organised weekly seminars for the Cell Sector.
- I was a member of the Quinquennial review committee for the Biological Sciences degree course.
- Since August 2006, I have been Deputy Head of Teaching and Learning (BIO)
- I am currently a member of working group for the Natural Sciences degree programme.