Career History

  • Senior Lecturer, University of East Anglia (2008-present)
  • The Humane Research Trust Lecturer, University of East Anglia (2002-2008)
  • Senior Research Associate - University of East Anglia (1997-2002)
  • PhD - University of East Anglia (1997)
  • BSc - Pharmacology, University of Portsmouth (1993)

All Publications

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Wormstone, I. M., Eldred, J. A.

(2016)

Experimental models for posterior capsule opacification research

in Experimental Eye Research

142.

pp. 2-12

Full Text UEA Repository

(Article)


Smith, A. F., Klotz, A., Wormstone, I. M.

(2016)

Improving the drug development process by reducing the impact of adverse events: the case of cataracts considered

in Drug Discovery Today

21.

pp. 510-516

Full Text UEA Repository

(Article)


Raghavan, C., Smuda, M., Smith, A., Howell, S., Smith, D., Singh, A., Gupta, P., Glomb, M., Wormstone, I., Nagaraj, R.

(2016)

AGEs in human lens capsule promote the TGFβ2-mediated EMT of lens epithelial cells: Implications for age-associated fibrosis

in Aging Cell

15.

pp. 465–476

Full Text UEA Repository

(Article)


Smith, A., Ball, S., Bowater, R., Wormstone, I.

(2016)

PARP-1 inhibition influences the oxidative stress response of the human lens

in Redox Biology

8.

pp. 354-362

Full Text UEA Repository

(Article)


Eldred, J. A., McDonald, M., Wilkes, H. S., Spalton, D. J., Wormstone, I. M.

(2016)

Growth factor restriction impedes progression of wound healing following cataract surgery: identification of VEGF as a putative therapeutic target

in Scientific Reports

6.

Full Text UEA Repository

(Article)


Smith, A. J. O., Ball, S. S. R., Manzar, K., Bowater, R. P., Wormstone, I. M.

(2015)

Ku80 Counters Oxidative Stress-Induced DNA Damage and Cataract Formation in the Human Lens

in Investigative Ophthalmology and Visual Science

56.

pp. 7868-7874

Full Text UEA Repository

(Article)


Spalton, D. J., Russell, S. L., Evans-Gowing, R., Eldred, J. A., Wormstone, I. M.

(2014)

Effect of total lens epithelial cell destruction on intraocular lens fixation in the human capsular bag

in Journal of Cataract and Refractive Surgery

40.

pp. 306-312

Full Text UEA Repository

(Article)


Eldred, J. A., Spalton, D. J., Wormstone, I. M.

(2014)

An In Vitro Evaluation of the Anew Zephyr Open-Bag IOL in the Prevention of Posterior Capsule Opacification Using a Human Capsular Bag Model

in Investigative Ophthalmology and Visual Science

55.

pp. 7057-7064

Full Text UEA Repository

(Article)


Wormstone, I., Eldred, J., Dawes, L.

(2014)

Fibrotic modifications of the lens epithelium

Springer

pp. 143-158

ISBN 978-4-431-54299-5

(Chapter (peer-reviewed))


Liu, H., Smith, A. J., Lott, M. C., Bao, Y., Bowater, R. P., Reddan, J. R., Wormstone, I. M.

(2013)

Sulforaphane Can Protect Lens Cells Against Oxidative Stress: Implications for Cataract Prevention

in Investigative Ophthalmology & Visual Science

54.

pp. 5236-5248

Full Text UEA Repository

(Article)


Fang, C., Illingworth, C. D., Qian, L., Wormstone, I. M.

(2013)

Serum Deprivation Can Suppress Receptor-Mediated Calcium Signaling in Pterygial-Derived Fibroblasts

in Investigative Ophthalmology & Visual Science

54.

pp. 4563-4570

Full Text UEA Repository

(Article)


Dawes, L. J., Duncan, G., Wormstone, I. M., Cells, Cultured, Lens, Crystalline

(2013)

Age-related differences in signaling efficiency of human lens cells underpin differential wound healing response rates following cataract surgery

in Investigative Ophthalmology & Visual Science

54.

pp. 333-42

Full Text UEA Repository

(Article)


Dawes, L., Illingworth, C., Wormstone, I.

(2012)

A fully human in vitro capsular bag model to permit intraocular lens evaluation

in Investigative Ophthalmology & Visual Science

53.

pp. 23-29

Full Text UEA Repository

(Article)


Eldred, J., Hodgkinson, L., Dawes, L., Reddan, J., Edwards, D., Wormstone, I.

(2012)

MMP2 Activity is Critical for TGF 2-Induced Matrix Contraction--Implications for Fibrosis

in Investigative Ophthalmology & Visual Science

53.

pp. 4085-4098

Full Text UEA Repository

(Article)


Rhodes, J., Lott, M., Russell, S., Moulton, V., Sanderson, J., Wormstone, I., Broadway, D.

(2012)

Activation of the innate immune response and interferon signalling in myotonic dystrophy type 1 and type 2 cataracts

in Human Molecular Genetics

21.

pp. 852-862

Full Text UEA Repository

(Article)


Wang, L., Eldred, J. A., Sidaway, P., Sanderson, J., Smith, A. J. O., Bowater, R. P., Reddan, J. R., Wormstone, I. M.

(2012)

Sigma 1 receptor stimulation protects against oxidative damage through suppression of the ER stress responses in the human lens

in Mechanisms of Ageing and Development

133.

pp. 665-674

Full Text UEA Repository

(Article)


Eldred, J., Dawes, L., Wormstone, I.

(2011)

The lens as a model for fibrotic disease

in Philosophical Transactions of the Royal Society B: Biological Sciences

366.

pp. 1301-1319

Full Text UEA Repository

(Article)


Hodgkinson, L., Wang, L., Duncan, G., Edwards, D., Wormstone, I.

(2010)

ADAM and ADAMTS gene expression in native and wound healing human lens epithelial cells

in Molecular Vision

16.

pp. 2765-2776

UEA Repository

(Article)


Wormstone, I.

(2010)

Posterior Capsule Opacification

Academic Press

pp. 469-475

ISBN 9780123742032

(Chapter (peer-reviewed))


Rhodes, J., Russell, S., Illingworth, C., Duncan, G., Wormstone, I.

(2009)

Regional Differences in Store-Operated Ca2+ Entry in the Epithelium of the Intact Human Lens

in Investigative Ophthalmology & Visual Science

50.

pp. 4330-4336

Full Text UEA Repository

(Article)


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Key Research Interests

I am a biomedical scientist with primary interests in the use of human tissue to study human eye disease. In particular, I am interested in wound-healing events that follow cataract surgery, which lead to a secondary visual loss known as posterior capsule opacification (PCO). Through the use of human tissue the laboratory aims to further our understanding of the cell and molecular mechanisms underpinning PCO and identify novel targets for future therapeutic development.

Video

Current Research Projects

  • Investigation of TGFß signalling involvement in matrix contraction and cell transdifferentiation
  • Gene expression and functional analysis of ocular cells
  • Development of human disease models to serve as pre-clinical evaluation tools
  • Optimise novel drug delivery mechanisms to prevent PCO

 

Life in our research group

The laboratory employs human ocular cell and tissue culture models as experimental systems to understand the human condition and develop appropriate therapies. The laboratory is equipped with dedicated state-of-the-art analysis tools that facilitate the research programme. There is a good blend of experienced post-doctoral scientists and enthusiastic students eager to learn. The group has international standing within our area of expertise and laboratory members get the opportunity to present their work across the world at meetings in North America, Asia and Europe. This experience is valuable to the development of individuals and the team as a whole.

PhD Positions 

Click here for current PhD opportunities in Biological Sciences. But feel free to email me to discuss projects outside these areas and alternative sources of funding.

Postdocs & Fellows

I am always happy to discuss possibilities for post-doctoral work and collaborations and Fellowship schemes with me acting as a sponsor.

External Activities and Indicators of Esteem

  • Industrial collaborations:Sugen Inc. - Fibroblast growth factor receptor inhibition; Cambridge Antibody Technology (now MedImmune) – Transforming growth factor beta inhibition;Milvella Ltd – Ocular drug delivery;Biologie Servier – Cytotoxicity testing; Anew Optics Inc– IOL development; Calpain Therapeutics – Drug development; Isarna Therapeutics – Drug development
  • Review for: Investigative Ophthalmology and Visual Sciences; Experimental Eye Research; British Journal of Ophthalmology; American Journal of Pathology; Molecular Vision
  • Co-inventor on three international patents. Use of calcium intracellular store inactivators and formulations thereof as cell growth inhibitors (#95 16458.8); Treatment of fibrotic eye disorders US 61/095547; Treatment of fibrotic eye disorders using an MMP2 inhibitor US 61/095554
  • 1995 & 1996 AER-Chauvin Prize. Awarded for the best abstract by a presenting author, under 35, at the annual JERMOV meeting. In receiving these awards I became the only person ever to win the prize twice, and in successive years.
  • 2008 Elected Fellow of the Royal Society of Medicine
  • 2009 Honorary Chair of Harbin Medical University
  • 2015 National Foundation for Eye Research (NFER) Cataract Research Award
  • 2016 Made a Fellow of the Association for Research in Vision and Ophthalmology (ARVO)
  • Editorial Board Member of IOVS

Administrative Posts

  • Human Physiology (BIO-2B05) Module Organiser.
  • Since January 2003-2005, I organised weekly seminars for the Cell Sector.
  • I was a member of the Quinquennial review committee for the Biological Sciences degree course.
  • From August 2006 to July 2011, I was Deputy Director of Teaching and Learning (School of Biological Sciences).
  • From 2009-2011, I was Chair of the Assessment Working Group within the School of Biological Sciences.
  • From August 2012-present, I am Senior Advisor with the School of Biological Sciences.