- Senior Lecturer, University of East Anglia (2008-present)
- The Humane Research Trust Lecturer, University of East Anglia (2002-2008)
- Senior Research Associate - University of East Anglia (1997-2002)
- PhD - University of East Anglia (1997)
- BSc - Pharmacology, University of Portsmouth (1993)
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A direct comparison of linear and star-shaped poly(dimethylaminoethyl acrylate) polymers for polyplexation with DNA and cytotoxicity in cultured cell linesFull Text UEA Repository
Experimental models for posterior capsule opacification researchFull Text UEA Repository
Improving the drug development process by reducing the impact of adverse events: the case of cataracts consideredFull Text UEA Repository
AGEs in human lens capsule promote the TGFβ2-mediated EMT of lens epithelial cells: Implications for age-associated fibrosisFull Text UEA Repository
PARP-1 inhibition influences the oxidative stress response of the human lensFull Text UEA Repository
Growth factor restriction impedes progression of wound healing following cataract surgery: identification of VEGF as a putative therapeutic targetFull Text UEA Repository
Ku80 Counters Oxidative Stress-Induced DNA Damage and Cataract Formation in the Human LensFull Text UEA Repository
Effect of total lens epithelial cell destruction on intraocular lens fixation in the human capsular bagFull Text UEA Repository
An In Vitro Evaluation of the Anew Zephyr Open-Bag IOL in the Prevention of Posterior Capsule Opacification Using a Human Capsular Bag ModelFull Text UEA Repository
Fibrotic modifications of the lens epithelium
Sulforaphane Can Protect Lens Cells Against Oxidative Stress: Implications for Cataract PreventionFull Text UEA Repository
Serum Deprivation Can Suppress Receptor-Mediated Calcium Signaling in Pterygial-Derived FibroblastsFull Text UEA Repository
Age-related differences in signaling efficiency of human lens cells underpin differential wound healing response rates following cataract surgeryFull Text UEA Repository
A fully human in vitro capsular bag model to permit intraocular lens evaluationFull Text UEA Repository
MMP2 Activity is Critical for TGF 2-Induced Matrix Contraction--Implications for FibrosisFull Text UEA Repository
Activation of the innate immune response and interferon signalling in myotonic dystrophy type 1 and type 2 cataractsFull Text UEA Repository
Sigma 1 receptor stimulation protects against oxidative damage through suppression of the ER stress responses in the human lensFull Text UEA Repository
The lens as a model for fibrotic diseaseFull Text UEA Repository
ADAM and ADAMTS gene expression in native and wound healing human lens epithelial cellsUEA Repository
Posterior Capsule Opacification
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Key Research Interests
I am a biomedical scientist with primary interests in the use of human tissue to study human eye disease. In particular, I am interested in wound-healing events that follow cataract surgery, which lead to a secondary visual loss known as posterior capsule opacification (PCO). Through the use of human tissue the laboratory aims to further our understanding of the cell and molecular mechanisms underpinning PCO and identify novel targets for future therapeutic development.
Current Research Projects
- Investigation of TGFß signalling involvement in matrix contraction and cell transdifferentiation
- Gene expression and functional analysis of ocular cells
- Development of human disease models to serve as pre-clinical evaluation tools
- Optimise novel drug delivery mechanisms to prevent PCO
Life in our research group
The laboratory employs human ocular cell and tissue culture models as experimental systems to understand the human condition and develop appropriate therapies. The laboratory is equipped with dedicated state-of-the-art analysis tools that facilitate the research programme. There is a good blend of experienced post-doctoral scientists and enthusiastic students eager to learn. The group has international standing within our area of expertise and laboratory members get the opportunity to present their work across the world at meetings in North America, Asia and Europe. This experience is valuable to the development of individuals and the team as a whole.
Postdocs & Fellows
I am always happy to discuss possibilities for post-doctoral work and collaborations and Fellowship schemes with me acting as a sponsor.
- Foundations for Physiology (BIO-1A58)
- Skills for Biologists (BIO-1A4Y)
- Introduction to Biomedicine (BIO-1A57)
- Cell Biology (BIO-2B06)
- Human Physiology (BIO-2B05)
- Advanced Cell Biology (BIO-3C18)
- Research Project (BIO-3C32)
External Activities and Indicators of Esteem
- Industrial collaborations:Sugen Inc. - Fibroblast growth factor receptor inhibition; Cambridge Antibody Technology (now MedImmune) – Transforming growth factor beta inhibition;Milvella Ltd – Ocular drug delivery;Biologie Servier – Cytotoxicity testing; Anew Optics Inc– IOL development; Calpain Therapeutics – Drug development; Isarna Therapeutics – Drug development
- Review for: Investigative Ophthalmology and Visual Sciences; Experimental Eye Research; British Journal of Ophthalmology; American Journal of Pathology; Molecular Vision
- Co-inventor on three international patents. Use of calcium intracellular store inactivators and formulations thereof as cell growth inhibitors (#95 16458.8); Treatment of fibrotic eye disorders US 61/095547; Treatment of fibrotic eye disorders using an MMP2 inhibitor US 61/095554
- 1995 & 1996 AER-Chauvin Prize. Awarded for the best abstract by a presenting author, under 35, at the annual JERMOV meeting. In receiving these awards I became the only person ever to win the prize twice, and in successive years.
- 2008 Elected Fellow of the Royal Society of Medicine
- 2009 Honorary Chair of Harbin Medical University
- 2015 National Foundation for Eye Research (NFER) Cataract Research Award
- 2016 Made a Fellow of the Association for Research in Vision and Ophthalmology (ARVO)
- Editorial Board Member of IOVS
- Human Physiology (BIO-2B05) Module Organiser.
- Since January 2003-2005, I organised weekly seminars for the Cell Sector.
- I was a member of the Quinquennial review committee for the Biological Sciences degree course.
- From August 2006 to July 2011, I was Deputy Director of Teaching and Learning (School of Biological Sciences).
- From 2009-2011, I was Chair of the Assessment Working Group within the School of Biological Sciences.
- From August 2012-present, I am Senior Advisor with the School of Biological Sciences.