Biography

Graham Riley is a biochemist with a research focus on the molecular pathology of tendon. A graduate of the University of Bristol, he has worked in a number of research areas in both academia and industry, including muscular dystrophy (Pasteur Institute, Paris), haemopoeitic stem cells (Institute of Cancer Research, London) and parasitology (Wellcome Laboratories, Beckenham). He completed his PhD at the Rheumatology Research Unit in Cambridge, investigating the biochemical changes that underlie chronic tendon pathology in the rotator cuff tendons of the shoulder. In 1996 he was appointed Head of the Soft Tissue Research Group at the Rheumatology Research Unit, and formed his own research group to investigate the cell and molecular pathology of tendons, ligaments and fascia.

Graham has an international reputation in the field of tendon pathology, and has published a number of key papers. In particular, his work on the role and regulation of metalloproteinases in tendon matrix turnover has resulted in several well-cited publications, and his contribution to the field was recognised by the award of a Senior Research Fellowship from Arthritis Research UK in 2007. He brought his research group to UEA the same year.

Career History

  • Arthritis Research UK Senior Research Fellow, University of East Anglia (2007-2012)
  • Head of Soft Tissue Injury and Repair Group, Rheumatology Research Unit (RRU) Addenbrooke’s Hospital, Cambridge (1996-2007)
  • Post-doctoral Research Assistant, RRU, Addenbrooke’s Hospital, Cambridge (1993-1996)
  • Research Assistant, RRU, Addenbrooke’s Hospital, Cambridge (1988-1993)
  • PhD – RRU, Addenbrooke’s Hospital, Cambridge (1993)
  • Research Assistant, Wellcome Laboratories, Beckenham, Kent (1987)
  • Research Assistant, Leukaemia Research Fund Laboratories, London (1984-1986)
  • Research Assistant, Pasteur Institute, Paris, France (1982-1984)
  • BSc - Biochemistry, University of Bristol (1981)

 

ResearcherID 

http://www.researcherid.com/rid/D-3809-2009

ResearchGate

https://www.researchgate.net/profile/Graham_Riley2/?ev=hdr_xprf

 

Highlighted Publications

See All

Thorpe, C. T., Riley, G. P., Birch, H. L., Clegg, P. D., Screen, H. R.

(2016)

Fascicles and the interfascicular matrix show adaptation for fatigue resistance in energy storing tendons,

in Acta Biomaterialia

42.

pp. 308–315

Full Text UEA Repository

(Article)

(Published)


Thorpe, C., Karunaseelan, K., Ng, J., Riley, G., Birch, H., Clegg, P., Screen, H. R. C.

(2016)

Distribution of proteins within different compartments of tendon varies according to tendon type,

in Journal of Anatomy

229.

pp. 450–458

Full Text UEA Repository

(Article)

(Published)


Thorpe, C. T., Godinho, M. S., Riley, G. P., Birch, H. L., Clegg, P. D., Screen, H. R.

(2015)

The interfascicular matrix enables fascicle sliding and recovery in tendon, and behaves more elastically in energy storing tendons,

in Journal of the Mechanical Behavior of Biomedical Materials

52.

pp. 85-94

Full Text UEA Repository

(Article)

(Published)


Spiesz, E. M., Thorpe, C. T., Chaudhry, S., Riley, G. P., Birch, H. L., Clegg, P. D., Screen, H. R. C.

(2015)

Tendon extracellular matrix damage, degradation and inflammation in response to in-vitro overload exercise,

in Journal of Orthopaedic Research

33.

pp. 889–897

Full Text UEA Repository

(Article)

(Published)


Waugh, C., Morrissey, D., Jones, E., Riley, G., Langberg, H., Screen, H.

(2015)

In vivo biological response to extracorporeal shockwave therapy in human tendinopathy: Response of tendinopathy to shockwave therapy ,

in European Cells and Materials 3

29.

pp. 268-280

UEA Repository

(Article)

(Published)


Shepherd, J., Riley, G., Screen, H.

(2014)

Early stage fatigue damage occurs in bovine tendon fascicles in the absence of changes in mechanics at either the gross or micro-structural level,

in Journal of the Mechanical Behavior of Biomedical Materials

38.

pp. 163-172

Full Text UEA Repository

(Article)

(Published)


Thorpe, C., Riley, G., Birch, H., Clegg, P., Screen, H.

(2014)

Fascicles from energy-storing tendons show an age-specific response to cyclic fatigue loading,

in Journal of The Royal Society Interface

11.

Full Text UEA Repository

(Article)

(Published)


Jones, E. R., Jones, G. C., Legerlotz, K., Riley, G. P.

(2013)

Cyclical strain modulates metalloprotease and matrix gene expression in human tenocytes via activation of TGFβ,

in Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

1833.

pp. 2596-2607

Full Text UEA Repository

(Article)

(Published)


Thorpe, C., Klemt, C., Riley, G., Birch, H., Clegg, P., Screen, H.

(2013)

Helical sub-structures in energy storing tendons provide a possible mechanism for efficient energy storage and return,

in Acta Biomaterialia

9.

pp. 7948-7956

Full Text UEA Repository

(Article)

(Published)


Legerlotz, K., Jones, G., Screen, H., Riley, G.

(2013)

Cyclic loading of tendon fascicles using a novel fatigue loading system increases interleukin-6 expression by tenocytes,

in Scandinavian Journal of Medicine & Science in Sports

23.

pp. 31-37

Full Text UEA Repository

(Article)

(Published)


Legerlotz, K., Jones, E., Screen, H., Riley, G.

(2012)

Increased expression of IL-6 family members in tendon pathology,

in Rheumatology

51.

pp. 1161-1165

Full Text UEA Repository

(Article)

(Published)


Corps, A., Robinson, A., Harrall, R., Avery, N., Curry, V., Hazleman, B., Riley, G.

(2012)

Changes in matrix protein biochemistry and the expression of mRNA encoding matrix proteins and metalloproteinases in posterior tibialis tendinopathy,

in Annals of the Rheumatic Diseases

71.

pp. 746-52

Full Text UEA Repository

(Article)

(Published)


Riley, G.

(2008)

Tendinopathy—from basic science to treatment,

in Nature Clinical Practice Rheumatology

4.

pp. 82-89

Full Text UEA Repository

(Article)

(Published)


Jones, G., Corps, A., Pennington, C., Clark, I., Edwards, D., Bradley, M., Hazleman, B., Riley, G.

(2006)

Expression profiling of metalloproteinases and tissue inhibitors of metalloproteinases in normal and degenerate human achilles tendon,

in Arthritis & Rheumatism

54.

pp. 832-842

Full Text UEA Repository

(Article)

(Published)


All Publications

See Highlights
<- Page 1 of 3 ->

Thorpe, C. T., Riley, G. P., Birch, H. L., Clegg, P. D., Screen, H. R. C.

(2017)

Fascicles and the interfascicular matrix show decreased fatigue life with ageing in energy storing tendons,

in Acta Biomaterialia

56

pp. 58–64

Full Text UEA Repository

(Article)

(Published)


Liao, X., Walden, G., Falcon, N. D., Donell, S., Raxworthy, M., Wormstone, M., Riley, G. P., Saeed, A.

(2017)

A direct comparison of linear and star-shaped poly(dimethylaminoethyl acrylate) polymers for polyplexation with DNA and cytotoxicity in cultured cell lines,

in European Polymer Journal

87

pp. 458–467

Full Text UEA Repository

(Article)

(Published)


Walden, G., Liao, X., Donell, S., Raxworthy, M. J., Riley, G., Saeed, A.

(2017)

A Clinical, Biological, and Biomaterials Perspective into Tendon Injuries and Regeneration,

in Tissue Engineering Part B: Reviews

23

(1)

pp. 44-58

Full Text

(Literature review)

(Published)


Thorpe, C. T., Riley, G. P., Birch, H. L., Clegg, P. D., Screen, H. R.

(2016)

Fascicles and the interfascicular matrix show adaptation for fatigue resistance in energy storing tendons,

in Acta Biomaterialia

42

pp. 308–315

Full Text UEA Repository

(Article)

(Published)


Thorpe, C., Karunaseelan, K., Ng, J., Riley, G., Birch, H., Clegg, P., Screen, H. R. C.

(2016)

Distribution of proteins within different compartments of tendon varies according to tendon type,

in Journal of Anatomy

229

(3)

pp. 450–458

Full Text UEA Repository

(Article)

(Published)


Thorpe, C. T., Godinho, M. S., Riley, G. P., Birch, H. L., Clegg, P. D., Screen, H. R.

(2015)

The interfascicular matrix enables fascicle sliding and recovery in tendon, and behaves more elastically in energy storing tendons,

in Journal of the Mechanical Behavior of Biomedical Materials

52

pp. 85-94

Full Text UEA Repository

(Article)

(Published)


English, A., Azeem, A., Spanoudes, K., Jones, E., Tripathi, B., Basu, N., McNamara, K., Tofail, S. A., Rooney, N., Riley, G., O'Riordan, A., Cross, G., Hutmacher, D., Biggs, M., Pandit, A., Zeugolis, D.

(2015)

Data on in vitro and in vivo cell orientation on substrates with different topographies,

in Data in Brief

5

pp. 379-382

Full Text UEA Repository

(Article)

(Published)


English, A., Azeem, A., Spanoudes, K., Jones, E., Tripathi, B., Basu, N., McNamara, K., Tofail, S. A., Rooney, N., Riley, G., O'Riordan, A., Cross, G., Hutmacher, D., Biggs, M., Pandit, A., Zeugolis, D.

(2015)

Substrate topography: A valuable in vitro tool, but a clinical red herring for in vivo tenogenesis,

in Acta Biomaterialia

27

pp. 3-12

Full Text UEA Repository

(Article)

(Published)


Thorpe, C. T., Chaudhry, S., Lei, I. I., Varone, A., Riley, G. P., Birch, H. L., Clegg, P. D., Screen, H. R. C.

(2015)

Tendon overload results in alterations in cell shape and increased markers of inflammation and matrix degradation,

in Scandinavian Journal of Medicine & Science in Sports

25

(4)

pp. e381–e391

Full Text UEA Repository

(Article)

(Published)


Spiesz, E. M., Thorpe, C. T., Chaudhry, S., Riley, G. P., Birch, H. L., Clegg, P. D., Screen, H. R. C.

(2015)

Tendon extracellular matrix damage, degradation and inflammation in response to in-vitro overload exercise,

in Journal of Orthopaedic Research

33

(6)

pp. 889–897

Full Text UEA Repository

(Article)

(Published)


Azeem, A., English, A., Kumar, P., Satyam, A., Biggs, M., Jones, E., Tripathi, B., Basu, N., Henkel, J., Vaquette, C., Rooney, N., Riley, G., O'Riordan, A., Cross, G., Ivanovski, S., Hutmacher, D., Pandit, A., Zeugolis, D.

(2015)

The influence of anisotropic nano- to micro-topography on in vitro and in vivo osteogenesis,

in Nanomedicine

10

(5)

pp. 693-711

Full Text UEA Repository

(Article)

(Published)


Waugh, C., Morrissey, D., Jones, E., Riley, G., Langberg, H., Screen, H.

(2015)

In vivo biological response to extracorporeal shockwave therapy in human tendinopathy: Response of tendinopathy to shockwave therapy ,

in European Cells and Materials 3

29

pp. 268-280

UEA Repository

(Article)

(Published)


Prideaux, M., Staines, K., Jones, E., Riley, G., Pitsillides, A., Farquharson, C.

(2015)

MMP and TIMP temporal gene expression during osteocytogenesis,

in Gene Expression Patterns

18

(1-2)

pp. 29–36

Full Text UEA Repository

(Article)

(Published)


Shepherd, J., Riley, G., Screen, H.

(2014)

Early stage fatigue damage occurs in bovine tendon fascicles in the absence of changes in mechanics at either the gross or micro-structural level,

in Journal of the Mechanical Behavior of Biomedical Materials

38

pp. 163-172

Full Text UEA Repository

(Article)

(Published)


Thorpe, C. T., Riley, G. P., Birch, H. L., Clegg, P. D., Screen, H. R. C.

(2014)

Effect of fatigue loading on structure and functional behaviour of fascicles from energy-storing tendons,

in Acta Biomaterialia

10

(7)

pp. 3217-3224

Full Text UEA Repository

(Article)

(Published)


Jones, E. R., Legerlotz, K., Riley, G. P.

(2014)

The effect of the matrix on mechanical regulation in human tenocytes,

in International Journal of Experimental Pathology

95

(3)

pp. A17-A18

(Abstract)

(Published)


Shepherd, J. H., Riley, G. P., Screen, H. R. C.

(2014)

Matrix damage as a result of cyclic creep loading occurs in the absence of changes in tendon mechanics at either the gross or micro-structural level,

in International Journal of Experimental Pathology

95

(3)

pp. A29-A30

(Abstract)

(Published)


Thorpe, C., Riley, G., Birch, H., Clegg, P., Screen, H.

(2014)

Fascicles from energy-storing tendons show an age-specific response to cyclic fatigue loading,

in Journal of The Royal Society Interface

11

(92)

article no. 20131058

Full Text UEA Repository

(Article)

(Published)


Shepherd, J. H., Legerlotz, K., Demirci, T., Klemt, C., Riley, G. P., Screen, H. R.

(2014)

Functionally distinct tendon fascicles exhibit different creep and stress relaxation behaviour,

in Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine

228

(1)

pp. 49-59

Full Text UEA Repository

(Article)

(Published)


Jones, E. R., Jones, G. C., Legerlotz, K., Riley, G. P.

(2013)

Cyclical strain modulates metalloprotease and matrix gene expression in human tenocytes via activation of TGFβ,

in Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

1833

(12)

pp. 2596-2607

Full Text UEA Repository

(Article)

(Published)


<- Page 1 of 3 ->

Key Research Interests

My primary research interest is the molecular pathology of soft connective tissues such as tendon and ligament. These tissues are common sites of injury, often affected by long-term pain and prone to rupture, even in non-athletic individuals. Our research uses techniques of cell and molecular biology, histology, immunohistochemistry and biochemistry. We collaborate with clinicians and surgeons at the Norfolk and Norwich Hospital, in particular the Institute of Orthopaedics, to obtain human tissue samples for analysis.

Current Research Projects

These include: 1) the development of in vitro models to study tendon cell biology 2) mechanobiology: investigating the mechanism of the cell response to applied mechanical load 3) tendon biomechanics: investigating the physical properties of the tendon extracellular matrix 4) clinical tissue studies: investigating cell and molecular changes in human connective tissue pathology.

Life in our research group

We investigate a number of questions relating to the causes of tendon pain and rupture. We occupy space in the Biomedical Research Centre, a modern purpose-built research building that is well equipped for cell and molecular biology. The open-plan laboratory brings us into everyday contact with other researchers with similar interests. We are part of the Cellular Protease Group (CPG), which has a broad interest in the role of proteases in a variety of different diseases. We are also an integral part of the Musculoskeletal Research Group, which has research interests in cartilage, bone, tendon, ligament and fascia, all common sites of joint disease. We collaborate with scientists and clinicians in UEA and the Norfolk and Norwich University Hospital, as well as colleagues outside the Norwich Research Park. For example, we have a major and growing collaboration with a team of biomedical engineers from Queen Mary, University of London. Our work is funded by major charities, such as Arthritis Research UK and The Wellcome Trust, as well as local charities such as Action Arthritis. We have regular lab meetings, attend seminars, and engage with other scientists from a range of disciplines at national and international research meetings. In a typical year we will present our work at the biannual conferences of the British Society for Matrix Biology and the annual conference of the British Society for Rheumatology. Highlights in 2013 include a plenary lecture at the Combined Orthopaedic Research Society meeting in Venice, Italy, and a keynote lecture at the International Symposium on Ligaments and Tendons in Arezzo, Italy.

PhD Positions

Click here for current PhD opportunities in Biological Sciences. But feel free to email me to discuss projects outside these areas and alternative sources of funding.

Postdocs & Fellows

I am always pleased to discuss possible research collaborations, grant applications and opportunities for graduate and postdoctoral appointments in my group. We can explore potential funding routes such as project grant applications and fellowships from bodies such as Arthritis Research UK, MRC, BBSRC, and the Wellcome Trust.

Teaching Interests

My teaching is largely in the area of ‘biomedicine’, the molecular basis of disease, at both undergraduate and post-graduate level. My lectures cover the composition and function of the extracellular matrix, and the cell and molecular changes which underlie different connective tissue diseases.

In addition, I particularly like to be involved in small group teaching, and participate in a variety of seminars that are designed to support student learning in subjects such as mathematics, chemistry, human physiology, cell biology and cancer biology.

I teach undergraduates and postgraduates on the following modules:

  • Skills for Biologists (4008Y)
  • Foundations for Chemistry and Physiology (4009Y)
  • Investigation of Human Disease (2B30)
  • Cell Biology (2B06)
  • Human Physiology (2B05)
  • Biomedicine (3C34)
  • Cancer Biology (3C27)
  • Frontiers in Molecular Medicine - MSc (M201)
  • Experimental Techniques in Molecular Medicine - MSc (M203)
  • Postgraduate Employability Programme (M82Y)
  • Research Skills (M64Y)
  • MBBS Module 02 - Locomotion (MED undergraduate teaching)
  • MSc Physiotherapy

External Activities and Indicators of Esteem

  • Scientific Organizer: First BSDB/BSMB joint meeting on "The Musculoskeletal System: from Development to Disease", September 2014, Norwich
  • Organiser of UEA symposia on tendon physiology and pathology, UEA (2010, 2012)
  • Treasurer of British Society for Matrix Biology (2004 - 2010)
  • Chair, British Society for Matrix Biology Young Investigator Award Committee, BSMB (2010 - present)
  • Member of Editorial Board, Scandinavian Journal of Medicine and Science in Sports (2008 - present)
  • Member of International Programme Committee, International Symposium on Ligament and Tendon (2010 - present)
  • Session Chair - Combined Orthopaedic Research Society (CORS) Venice, Italy (2013)
  • Session Chair - International Symposium on Ligaments and Tendon Arezzo, Italy (2013)

Enterprise and Engagement

  • Consultant for Wyeth Laboratories, Cambridge, USA (2006 - 2009)
  • Consultant for Syntaxin Ltd, Oxford, UK (2010)
  • PhD training programme course lecturer - Copenhagen, Denmark (2009 - present)

Administrative Posts

  • Chair of the UEA Animal Welfare and Ethical Review Body
  • Senior Adviser, School of Biological Sciences
  • Member of University Research Ethics Committee
  • Member of Senate Student Disciplinary Committee
  • Deputy Plagiarism & Collusion Officer, School of Biological Sciences
  • Module organiser, Modern Experimental Techniques in Molecular Medicine