All Publications

Liu, H., Smith, A. J. O., Ball, S. S. R., Bao, Y., Bowater, R. P., Wang, N., Wormstone, I. M.

(2017)

Sulforaphane promotes ER stress, autophagy and cell death: implications for cataract surgery,

in Journal of Molecular Medicine

95

(5)

pp. 553–564

Full Text UEA Repository

(Article)

(Published)


Cobb, A. M., Larrieu, D., Warren, D., Liu, Y., Srivastava, S., Smith, A. J., Bowater, R. P., Jackson, S. P., Shanahan, C. M.

(2016)

Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient,

in Aging Cell

15

(6)

pp. 1039–1050

Full Text UEA Repository

(Article)

(Published)


Smith, A., Ball, S., Bowater, R., Wormstone, I.

(2016)

PARP-1 inhibition influences the oxidative stress response of the human lens,

in Redox Biology

8

pp. 354-362

Full Text UEA Repository

(Article)

(Published)


Raghavan, C., Smuda, M., Smith, A., Howell, S., Smith, D., Singh, A., Gupta, P., Glomb, M., Wormstone, I., Nagaraj, R.

(2016)

AGEs in human lens capsule promote the TGFβ2-mediated EMT of lens epithelial cells: Implications for age-associated fibrosis,

in Aging Cell

15

(3)

pp. 465–476

Full Text UEA Repository

(Article)

(Published)


Smith, A. J. O., Ball, S. S. R., Manzar, K., Bowater, R. P., Wormstone, I. M.

(2015)

Ku80 Counters Oxidative Stress-Induced DNA Damage and Cataract Formation in the Human Lens,

in Investigative Ophthalmology and Visual Science

56

(13)

pp. 7868-7874

Full Text UEA Repository

(Article)

(Published)


Liu, H., Smith, A. J., Lott, M. C., Bao, Y., Bowater, R. P., Reddan, J. R., Wormstone, I. M.

(2013)

Sulforaphane Can Protect Lens Cells Against Oxidative Stress: Implications for Cataract Prevention,

in Investigative Ophthalmology & Visual Science

54

(8)

pp. 5236-5248

Full Text UEA Repository

(Article)

(Published)


Wang, L., Eldred, J. A., Sidaway, P., Sanderson, J., Smith, A. J. O., Bowater, R. P., Reddan, J. R., Wormstone, I. M.

(2012)

Sigma 1 receptor stimulation protects against oxidative damage through suppression of the ER stress responses in the human lens,

in Mechanisms of Ageing and Development

133

(11-12)

pp. 665-674

Full Text UEA Repository

(Article)

(Published)


Key Research Interests

My research is centred on the use of human cells and human donor tissue to investigate aspects of lens cell biology and disease, focusing on cataract and fibrotic changes which give rise to posterior capsule opacification, or secondary cataract.