All projects are underpinned by a strong emphasis on synthetic methods applied to therapeutic problems and the group collaborates extensively with other colleagues in the School, where there are strengths in synthesis, biological chemistry, cell biology and drug delivery. A large number of collaborations also exist with other schools in UEA and with other institutions.

Ganesan research image

Prof Ganesan

  • Organic synthesis of biologically active natural products
  • Synthesis of epigenetic enzyme inhibitors
  • Synthesis of therapeutically relevant protease inhibitors, calcium signalling probes and antibiotics
Chris Hamilton research image

Dr Chris Hamilton

  • Chemical and biochemical functions of low molecular weight thiols in Gram positive bacteria.
  • Redox mechanisms of bioactive organosulfur metabolites from garlic
  • Mechanistic enzymology
Lesley Howell research image

Dr Lesley Howell

  • Investigation of protein-protein interactions associated with cancer
  • Synthesis of small molecules to inhibit protein-protein interactions
  • Synthesis of novel antibacterial agents targeting DNA gyrase
Sue Matthews research image

Dr Susan Matthews

  • Gene delivery through functionalised multicalixarenes
  • Site-specific pro-drug systems for new anti-cancer agents
  • Synthesis of new macrocyclic systems
Paul McDermott research image

Dr Paul McDermott

  • Synthesis of Analogues of Symplostatin 4 for QSAR studies
  • Synthesis of Analogues of Simocyclinone D8 as potential antiobiotic compounds
  • Development of Novel E-learning resources for Undergraduate Pharmacy Students
Mark Searcey research image

Prof Mark Searcey

  • Inhibition of protein-DNA and protein-protein interactions
  • Targeting nucleic acid and DNA repair and proliferation
  • Solution and solid phase natural product synthesis from synthetic sources
Zoe Waller research image Dr Zoƫ Waller

 

  • Synthesis of small molecule chemical probes for biology
  • Study of alternative nucleic acid secondary structures which may have biological function
  • Improvement of current DNA binding drugs