Publications and Papers

The latest research publications and papers from within the school of Pharmacy.

Selectivity in the impact of P-glycoprotein upon pulmonary absorption of airway-dosed substrates: A study in ex vivo lung models using chemical inhibition and genetic knockout.
Al-Jayyoussi, Ghaith, Price, Daniel F., Francombe, Danielle, Taylor, Glyn, Smith, Mathew W., Morris, Christopher, Edwards, Chris D., Eddershaw, Peter and Gumbleton, Mark
Journal of Pharmaceutical Sciences, 2013. n/a-n/a. ISSN 0022-3549
DOI: 10.1002/jps.23587

Maximal extent of translocation of single-walled carbon nanotubes from lung airways of the rat.
Matthews, IP, Gregory, CJ, Aljayyoussi, G, Morris, CJ, Mcdonald, I, Hoogendoorn, B and Gumbleton, M
Environmental Toxicology and Pharmacology, 2013, 35 (3). pp. 461-464. ISSN 13826689
DOI: 10.1016/j.etap.2013.02.002

Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface.
Salvati, A, Pitek, AS, Monopoli, MP, Prapainop, K, Baldelli Bombelli, F, Hristov, DR, Kelly, PM, Aberg, C, Mahon, E and Dawson, KA.
Nature Nanotechnology, 2013, 8 (2). pp. 137-143. ISSN 1748-3387
DOI: 10.1038/nnano.2012.237

S-bacillithiolation protects conserved and essential proteins against hypochlorite stress in Firmicutes bacteria
B.K. Chi, A.A. Roberts, T.T.T. Huyen, K. Gronau, D. Becher, D. Albrecht, C.J. Hamilton, H. Antelmann.*
Antioxidants & Redox Signaling. 2013, 18(11): 1273-1295
DOI:10.1089/ars.2012.4686.

Stability of aminooxy glycosides to glycosidase catalysed hydrolysis
A. Iqbal, H. Chibli, C. J. Hamilton,
Carbohydr. Res. 2013 (in press)
DOI: 10.1016/j.carres.2013.05.006

Differential regulation of chemotaxis: Role of Gβγ in chemokine receptor-induced cell migration.
Kerr JS, Jacques RO, Moyano Cardaba C, Tse T, Sexton D, Mueller A.
Cell Signal, 2013, 25(4), 729–735.
DOI:10.1016/j.cellsig.2012.12.015. [Epub ahead of print]

The Role of the Mucus Barrier in Digestion
Mackie, AR, Round, A, Rigby, NM and Macierzanka, A
Food Digestion, 2012, 3, 1-3, 8-15
DOI: 10.1007/s13228-012-0021-1

Designing the nanoparticle–biomolecule interface for "targeting and therapeutic delivery".
Mahon, E, Salvati, A, Baldelli Bombelli, F, Lynch, I and Dawson, KA
J Control Release. 2012 Jul 20;161 (2):164-74 22516097
DOI: 10.1016/j.jconrel.2012.04.009

Lamellar Structures of MUC2-Rich Mucin: A Potential Role in Governing the Barrier and Lubricating Functions of Intestinal Mucus
Round, AN, Rigby, NM, Garcia de la Torre, A, Macierzanka, A, Mills, ENC and Mackie, AR
Biomacromolecules, 2012, 13 (10). pp. 3253-3261. ISSN 1526-4602
DOI: 10.1021/bm301024x

Distribution and infection related functions of bacillithiol in Staphylococcus aureus
D. Pöther, P. Gierok, M. Harms3, J. Mostertz, F. Hochgräfe, H. Antelmann, C.J. Hamilton, I. Borovok, M. Lalk, Y. Aharonowitz, M. Hecker*
Int. J. Med. Microbiol. 2012, 303, 3, 114–123
DOI: 10.1016/j.ijmm.2013.01.003

Reversible versus Irreversible Binding to Transferrin to Polystyrene Nanoparticles: Soft and Hard Corona.
Milani, S, Baldelli Bombelli, F, Pitek, A, Dawson, KA and Radler, J
ACS Nano, 2012, 6(3). pp. 2532-2541.
DOI: 10.1021/nn204951s

Low molecular weight thiols in thiol-disulfide exchange
K.V. Laer, C. Hamilton,^* J. Messens.^*
Antiox Redox Signal 2012, 18(13): 1642-1653.
DOI:10.1089/ars.2012.4964.

Conformational Changes Undergone by Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase Upon Substrate Binding: The Role of N-lobe and Enantiomeric Substrate Preference
J. Ignacio, J. S-Aparicio, H. Whitfield, C. Hamilton, C. Brearly,* B. Gonzalez.*
J. Biol. Chem. 2012 287, 29237-29249
DOI: 10.1074/jbc.M112.363671

Janus kinase 2 and signal transducer and activator of transcription 3 activation is not essential for CCL3-, CCL5- or CCL8-induced chemotaxis.
Khabbazi S, Jacques RO, Moyano Cardaba C, Mueller A
Cell Biochemistry and Function, 2012
DOI: 10.1002/cbf.2901

Cellular uptake studies of two hexanuclear, carboxylate bridged, zinc ring structures using fluorescence microscopy
Redshaw C, Elsegood MR, Frese JW, Ashby S, Chao Y, Mueller A.
Chem Commun (Camb). 2012 Jul 7;48(53):6627-9. Epub 2012 May 1
DOI: 10.1039/C2CC32060F

Transferrin Coated Nanoparticles: Study of the Bionano Interface in Human Plasma
Pitek AS, O'Connell D, Mahon E, Monopoli MP, Baldelli Bombelli F, et al.
PLoS ONE 2012 7(7): e40685.
DOI:10.1371/journal.pone.0040685

Antitumor activity of a duocarmycin analogue rationalised to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder.
Sutherland M, Gill JH, Loadman PM, Laye JP, Sheldrake HM, Illingworth NA, Alandas MN, Cooper PA, Searcey M, Pors K, Shnyder SD, Patterson LH.
Mol Cancer Ther. 2012 Oct 1.

A model for a solvent-free synthetic organic research laboratory: click-mechanosynthesis and structural characterization of thioureas without bulk solvents
Vjekoslav Štrukil, Marina D. Igrc, László Fábián, Mirjana Eckert-Maksić, Scott L. Childs, David G. Reid, Melinda J. Duer, Ivan Halasz, Cristina Mottillo and Tomislav Friščić
Green Chem., 2012,14, 2462-2473
DOI: 10.1039/C2GC35799B

The Development of Thermal Nanoprobe Methods as a Means of Characterizing and Mapping Plasticizer Incorporation into Ethylcellulose Films
Meng J, Levina M, Rajabi-Siahboomi AR, Round AN, Reading M, Craig DQM
Pharm. Res. 2012, 29, (8), 2128-2138
DOI: 10.1007/s11095-012-0742-4

Research